Patent US5273039A successfully refreshed from Google Patents.
US4299919A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Perfusate redox potential controller
Assignee: Saint Louis University
•
Filing: 1980-06-30
•
Granted: 1981-11-10
•
Expires: 2000-06-30
Abstract
Abstract Apparatus for controlling the redox potential of a perfusate for use in the preservation of organs to be transplanted and the like, which apparatus includes first and second cells, a membrane with a submicron pore size disposed in openings between the cells, first and second electrodes disposed in the first and second cells respectively, a reference electrode adapted to be in electrical contact with the perfusate, and circuitry for detecting the redox potential of the perfusate as measured against the reference electrode and for maintaining the redox potential at a predetermined level by causing current to flow between the first and second electrodes through the perfusate when the measured redox potential differs from the predetermined level. The first cell has first and second ports for ingress and egress of the perfusate into and out of the first cell. The membrane allows electrical current to flow between the first and second cells but prevents particles larger than the pore size from passing from one cell to the other.
Inventors
- 👤 Max Jellinek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:57
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/16; A01N1/168; A01N1/14; A01N1/142; A01N1/143
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
188 words
In a perfusion apparatus including an organ chamber, an oxygenator and a pump for pumping a perfusate through the apparatus, the improvement comprising means for controlling the redox potential of the perfusate for use in the preservation of organs comprising: first and second cells, each having an opening for communication of fluid therebetween, said first cell also having first and second ports for ingress and egress of the perfusate into and out of said first cell; a membrane disposed in the openings between the first and second cells, said membrane having a submicron pore size, whereby electrical current can flow between the first and second cells but particles larger than the pore size cannot; first and second electrodes disposed in the first and second cells respectively; a reference electrode adapted to be in electrical contact with the perfusate; and means for detecting the redox potential of the perfusate as measured against the reference electrode and for maintaining said redox potential at a predetermined level by causing current to flow between the first and second electrodes through said perfusate when the measured redox potential differs from the predetermined level.
Claim 2
Dependent Claim
188 words
In a perfusion apparatus including an organ chamber, an oxygenator and a pump for pumping a perfusate through the apparatus, the improvement comprising means for controlling the redox potential of the perfusate for use in the preservation of organs comprising: first and second cells, each having an opening for communication of fluid therebetween, said first cell also having first and second ports for ingress and egress of the perfusate into and out of said first cell; a membrane disposed in the openings between the first and second cells, said membrane having a submicron pore size, whereby electrical current can flow between the first and second cells but particles larger than the pore size cannot; first and second electrodes disposed in the first and second cells respectively; a reference electrode adapted to be in electrical contact with the perfusate; and means for detecting the redox potential of the perfusate as measured against the reference electrode and for maintaining said redox potential at a predetermined level by causing current to flow between the first and second electrodes through said perfusate when the measured redox potential differs from the predetermined level.
Claim 3
Dependent Claim
50 words
Apparatus as set forth in claim 1 wherein the first and second cells are disposed adjacent each other with their respective openings in abutting relationship, further including means for providing a watertight seal around the membrane whereby fluid passing from one cell to the other must pass through the membrane.
Claim 4
Dependent Claim
19 words
Apparatus as set forth in claim 1 wherein the second cell has a port for use as a vent.
Claim 5
Dependent Claim
20 words
Apparatus as set forth in claim 3 wherein the second electrode is disposed adjacent said port in the second cell.
Claim 6
Dependent Claim
20 words
Apparatus as set forth in claim 4 wherein the second electrode is coaxial with said port in the second cell.
Claim 7
Dependent Claim
24 words
Apparatus as set forth in claim 1 wherein the first electrode is disposed adjacent the ingress port of the first cell and coaxial therewith.
Claim 8
Dependent Claim
28 words
Apparatus as set forth in claim 1 wherein the axis of the egress port is at an acute angle with respect to the axis of the ingress port.
Claim 9
Dependent Claim
16 words
Apparatus as set forth in claim 1 wherein the first electrode has a cylindrically shaped body.
Claim 10
Dependent Claim
29 words
Apparatus as set forth in claim 8 wherein the first electrode is disposed so that during operation the perfusate flows both inside and outside the cylindrically shaped electrode body.
Claim 11
Dependent Claim
27 words
Apparatus as set forth in claim 8 wherein the first electrode is composed of a material selected from the group consisting of platinum and reticulated vitreous carbon.
Claim 12
Dependent Claim
39 words
Apparatus as set forth in claim 1 wherein the reference electrode is partially disposed in the first cell whereby the redox potential detected by the detecting and maintaining means is the potential of the perfusate in the first cell.
Claim 13
Dependent Claim
16 words
Apparatus as set forth in claim 11 wherein the reference electrode is a silver/silver chloride electrode.
Claim 14
Dependent Claim
20 words
Apparatus as set forth in claim 1 wherein the pore size of the membrane is no greater than 0.5 microns.
Claim 15
Dependent Claim
14 words
Apparatus as set forth in claim 13 wherein said pore size is 0.45 microns.
Claim 16
Dependent Claim
16 words
Apparatus as set forth in claim 1 wherein the second electrode has a cylindrically shaped body.
Claim 17
Dependent Claim
27 words
Apparatus as set forth in claim 1 wherein the second electrode is composed of a material selected from the group consisting of platinum and reticulated vitreous carbon.
Claim 18
Dependent Claim
34 words
Apparatus as set forth in claim 1 wherein the detecting and maintaining means includes means for supplying a reducing current to the first cell when the measured redox potential is above the predetermined level.
Claim 19
Dependent Claim
34 words
Apparatus as set forth in claim 1 wherein the detecting and maintaining means includes means for supplying an oxidizing current to the first cell when the measured redox potential is below the predetermined level.
Claim 20
Dependent Claim
19 words
Apparatus as set forth in claim 1 further including means for displaying the measured redox potential of the perfusate.
References Cited (Backward Citations)
US3151052A
Cited
US3498888A
Cited
US3772153A
Cited
US3892628A
Cited
US3753865A
Cited
US3914954A
Cited
US3935065A
Cited
US3995444A
Cited
US4170523A
Cited
US4149950A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-09 | 1985-05-11 | 1985-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-09 | 1989-05-11 | 1989-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-09 | 1993-05-11 | 1993-11-10 | $7700.00 | Window Closed / Lapsed |