US4290910A
Expired / Lapsed
US
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Fatty emulsion and process for the preparation thereof
Assignee: Tanabe Pharma Corp
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Filing: 1979-08-30
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Granted: 1981-09-22
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Expires: 1999-08-30
Abstract
Abstract A stable, oil-in-water type, fine particle, fatty emulsion which is regulated with a pH value regulator consisting of an organic amine and a buffer solution to a pH value of 6.0 to 8.0, said fatty emulsion having a fatty particle size of not larger than 2 mu . The fatty emulsion can stably be kept for a long period of time without lowering of the pH value and aggregation of the fatty particles.
Inventors
- 👤 Kiyoshi Harada
- 👤 Yoshiyuki Koida
- 👤 Hiroshi Miura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0029; A61P; A61P3/00; A61P3/06; Y; Y10; Y10S; Y10S516/00; Y10S516/905; Y10S516/907; Y10S516/917; Y10S516/918
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
87 words
A fatty emulsion comprising an oil-in-water type fatty emulsion which is regulated to a pH value of 6.0 to 8.0 with a pH value regulator consisting of a combination of at least one organic amine selected from the group consisting of lysine, arginine, ornithine, histidine, trishydroxymethylaminomethane and triethanolamine and at least one buffer solution selected from the group consisting of a potassium dihydrogen phosphate-dipotassium hydrogen phosphate buffer, potassium dihydrogen phosphate-disodium hydrogen phosphate, potassium dihydrogen phosphate-trisodium phosphate, sodium dihydrogen phosphate-disodium hydrogen phosphate, citric acid-disodium hydrogen phosphate, and tris-HCl.
Claim 2
Dependent Claim
87 words
A fatty emulsion comprising an oil-in-water type fatty emulsion which is regulated to a pH value of 6.0 to 8.0 with a pH value regulator consisting of a combination of at least one organic amine selected from the group consisting of lysine, arginine, ornithine, histidine, trishydroxymethylaminomethane and triethanolamine and at least one buffer solution selected from the group consisting of a potassium dihydrogen phosphate-dipotassium hydrogen phosphate buffer, potassium dihydrogen phosphate-disodium hydrogen phosphate, potassium dihydrogen phosphate-trisodium phosphate, sodium dihydrogen phosphate-disodium hydrogen phosphate, citric acid-disodium hydrogen phosphate, and tris-HCl.
Claim 3
Dependent Claim
23 words
A fatty emulsion according to claim 1 wherein said organic amine is selected from the group consisting of lysine, arginine, trishydroxymethylaminomethane and triethanolamine.
Claim 4
Dependent Claim
63 words
An oil-in-water type fatty emulsion according to claim 1 comprising about 3 to 30 W/V % of a vegetable oil; about 0.3 to 5.0 W/V % of an emulsifying agent; about 0.001 to 0.05 W/V % of said organic amine, about 0.05 to 4.0 mM of said buffer solution, the remainder being water, and having a fatty particle size not larger than 2μ.
Claim 5
Dependent Claim
18 words
An oil-in-water type fatty emulsion according to claim 1, having a fatty particle size not larger than 2μ.
Claim 6
Dependent Claim
23 words
A fatty emulsion according to claim 4, wherein the emulsifying agent is selected from the group consisting of phospholipids and polyoxyethylene-hydrogenated castor oil.
Claim 7
Dependent Claim
27 words
A fatty emulsion according to claim 4, wherein the emulsifying agent is a member selected from the group consisting of soy bean phospholipids and egg yolk phospholipids.
Claim 8
Dependent Claim
22 words
A fatty emulsion according to claim 4, 5, or 6 wherein said emulsion has a pH value of about 7.0 to 7.5.
Claim 9
Dependent Claim
18 words
A fatty emulsion according to claim 4, 5, or 6 wherein the vegetable oil is soy bean oil.
Claim 10
Dependent Claim
24 words
A fatty emulsion according to claim 4, 5, or 6 wherein said regulator is a combination of trishydroxymethylaminomethane and potassium dihydrogen phosphate-disodium hydrogen phosphate.
Claim 11
Dependent Claim
24 words
A fatty emulsion according to claim 4, 5, or 6 wherein said regulator is a combination of lysine and potassium dihydrogen phosphate-disodium hydrogen phosphate.
Claim 12
Dependent Claim
24 words
A fatty emulsion according to claim 4, 5, or 6 wherein said regulator is a combination of triethanolamine and potassium dihydrogen phosphate-disodium hydrogen phosphate.
Claim 13
Dependent Claim
24 words
A fatty emulsion according to claim 4, 5, or 6 wherein said regulator is a combination of arginine and potassium dihydrogen phosphate-disodium hydrogen phosphate.
Claim 14
Dependent Claim
24 words
A fatty emulsion according to claim 4, 5 or 6 wherein said regulator is a combination of arginine and potassium dihydrogen phosphate-dipotassium hydrogen phosphate.
Claim 15
Dependent Claim
23 words
A fatty emulsion according to claim 4, 5 or 6 wherein said regulator is a combination of arginine and potassium dihydrogen phosphate-trisodium phosphate.
Claim 16
Dependent Claim
23 words
A fatty emulsion according to claim 4, 5 or 6 wherein said regulator is a combination of arginine and citric acid-disodium hydrogen phosphate.
Claim 17
Dependent Claim
20 words
A fatty emulsion according to claim 4, 5 or 6 wherein said regulator is a combination of arginine and tris-HCl.
Claim 18
Dependent Claim
23 words
A fatty emulsion according to claim 4, 5 or 6 wherein said regulator is a combination of trishydroxymethylaminomethane and citric acid-sodium hydrogen phosphate.
Claim 19
Dependent Claim
23 words
A fatty emulsion according to claim 4, 5, or 6 wherein said regulator is a combination of lysine and citric acid-disodium hydrogen phosphate.
Claim 20
Dependent Claim
99 words
A process for the preparation of a fatty emulsion which comprises emulsifying a vegetable oil into an aqueous dispersion of an emulsifying agent; adding to the resulting crude emulsion a pH value regulator consisting of at least one organic amine selected from the group consisting of lysine, arginine, ornithine, histidine, trishydroxymethylaminomethane and triethanolamine and at least one buffer selected from the group consisting of a phosphate buffer, a citric acid-phosphate buffer and tris-HCl buffer to regulate a pH value thereof to a pH range of 6.0 to 8.0; and emulsifying the mixture completely to give an oil-in-water fatty emulsion.
Claim 21
Dependent Claim
99 words
A process for the preparation of a fatty emulsion which comprises emulsifying a vegetable oil into an aqueous dispersion of an emulsifying agent; adding to the resulting crude emulsion a pH value regulator consisting of at least one organic amine selected from the group consisting of lysine, arginine, ornithine, histidine, trishydroxymethylaminomethane and triethanolamine and at least one buffer selected from the group consisting of a phosphate buffer, a citric acid-phosphate buffer and tris-HCl buffer to regulate a pH value thereof to a pH range of 6.0 to 8.0; and emulsifying the mixture completely to give an oil-in-water fatty emulsion.
Claim 22
Dependent Claim
22 words
A process according to claim 19 wherein said organic amine is selected from the group consisting of lysine, arginine, trishydroxymethylaminomethane and triethanolamine.
Claim 23
Dependent Claim
64 words
A process according to claim 20 wherein said fatty emulsion comprises about 3 to 30 W/V % of said vegetable oil, about 0.3 to 5.0 W/V % of said emulsifying agent, about 0.001 to 0.05 W/V % of said organic amine, about 0.05 to 4.0 nM of said buffer solution, the remainder being water, and having a fatty particle size not larger than 2μ.
Claim 24
Dependent Claim
98 words
A process for the preparation of a fatty emulsion, which comprises emulsifying a vegetable oil into an aqueous dispersion of an emulsifying agent; emulsifying further the resulting crude emulsion to give an oil-in-water type fatty emulsion; and adding thereto a pH value regulator consisting of at least one organic amine selected from the group consisting of lysine, arginine, ornithine, histidine, trishydroxymethylaminomethane and triethanolamine and at least one buffer selected from the group consisting of a phosphate buffer, a citric acid-phosphate buffer and tris-HCl buffer to regulate a pH value thereof to a pH range of 6.0 to 8.0.
Claim 25
Dependent Claim
98 words
A process for the preparation of a fatty emulsion, which comprises emulsifying a vegetable oil into an aqueous dispersion of an emulsifying agent; emulsifying further the resulting crude emulsion to give an oil-in-water type fatty emulsion; and adding thereto a pH value regulator consisting of at least one organic amine selected from the group consisting of lysine, arginine, ornithine, histidine, trishydroxymethylaminomethane and triethanolamine and at least one buffer selected from the group consisting of a phosphate buffer, a citric acid-phosphate buffer and tris-HCl buffer to regulate a pH value thereof to a pH range of 6.0 to 8.0.
Claim 26
Dependent Claim
29 words
A process for the preparation of a fatty emulsion according to claim 22 wherein said organic amine is selected from the group consisting of lysine, arginine, trishydroxymethylaminomethane and triethanolamine.
Claim 27
Dependent Claim
55 words
A process according to claim 22, wherein said fatty emulsion comprises about 3 to 30 W/V % of said vegetable oil, about 0.3 to 5.0 W/V % of said organic amine, about 0.05 to 4.0 mM of said buffer solution, the remainder being water, and having a fatty particle size of not larger than 2μ.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-21 | 1985-03-23 | 1985-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-21 | 1989-03-23 | 1989-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-21 | 1993-03-23 | 1993-09-22 | $7700.00 | Window Closed / Lapsed |