US4282143A
Expired / Lapsed
US
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Octapeptides lowering growth hormone
Assignee: Wyeth LLC
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Filing: 1980-06-13
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Granted: 1981-08-04
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Expires: 2000-06-13
Abstract
Abstract Polypeptides of the formula: ##STR1## in which X 1 is Phe, D-Phe or C 6 H 5 CH 2 CH 2 CO--; X 2 is Phe, Tyr, Trp, Met or Leu; X 3 is Trp or D-Trp; X 4 is Thr, Val, α-Abu or Phe; and X 5 is Phe, D-Phe or --NHCH 2 CH 2 C 6 H 5 ; the linear precursor intermediates thereof and pharmaceutically acceptable salts and amides thereof are selective inhibitors of growth hormone release without materially altering blood serum levels of glucagon or insulin. In addition, the above-described compounds are active growth hormone suppressants for periods as long as two hours.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:55
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/26
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
84 words
A compound of the formula: ##STR5## in which X 1 is Phe, D-Phe or C 6 H 5 CH 2 CH 2 CO--; X 2 is Phe, Tyr, Trp, Met or Leu; X 3 is Trp or D-Trp; X 4 is Thr, Val, α-Abu or Phe; and X 5 is Phe, D-Phe or --NHCH 2 CH 2 C 6 H 5 and the A groups are hydrogen or a direct bond between the two sulfur atoms; or a pharmaceutically acceptable salt or amide thereof.
Claim 2
Dependent Claim
84 words
A compound of the formula: ##STR5## in which X 1 is Phe, D-Phe or C 6 H 5 CH 2 CH 2 CO--; X 2 is Phe, Tyr, Trp, Met or Leu; X 3 is Trp or D-Trp; X 4 is Thr, Val, α-Abu or Phe; and X 5 is Phe, D-Phe or --NHCH 2 CH 2 C 6 H 5 and the A groups are hydrogen or a direct bond between the two sulfur atoms; or a pharmaceutically acceptable salt or amide thereof.
Claim 3
Dependent Claim
14 words
A compound of claim 1 which is ##STR6## or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
8 words
A compound of claim 1 which is ##STR7##
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-03 | 1985-02-02 | 1985-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-03 | 1989-02-02 | 1989-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-03 | 1993-02-02 | 1993-08-04 | $7700.00 | Window Closed / Lapsed |