US4268495A
Expired / Lapsed
US
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Injectable embolization and occlusion solution
Assignee: Ethicon Inc
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Filing: 1979-01-08
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Granted: 1981-05-19
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Expires: 1999-01-08
Abstract
Abstract An injectable embolization and occlusion solution for the selective closure of organs, their duct systems, or blood vessels, comprises a solution of a prolamine such as zein in a physiologically compatible solvent such as ethanol. The solution is injected into the site to be treated where the prolamine quickly precipitates in the body fluids to occlude the site area.
Inventors
- 👤 Hans Muxfeldt
- 👤 Hermann Dahlke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:09
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/168
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
33 words
A method for occluding the vascular or duct system of a living organ by injecting into the organ at the site to be occluded a solution comprising prolamine in a physiologically compatible solvent.
Claim 2
Independent Claim
33 words
A method for occluding the vascular or duct system of a living organ by injecting into the organ at the site to be occluded a solution comprising prolamine in a physiologically compatible solvent.
Claim 3
Dependent Claim
19 words
A method of claim 1 wherein the prolamine is selected from the group consisting of zein, gliadin and hordein.
Claim 4
Dependent Claim
36 words
A method of claim 1 wherein the solvent is selected from the group consisting of C 2 -C 5 alcohols, ethylenediamine, 1-acetylpiperidine, ethylene glycol, propylene glycol, glycerol, N-methylacetamide, formamide, hydrazine, dimethylformamide, dimethylsulphoxide, and aqueous solutions thereof.
Claim 5
Dependent Claim
20 words
A method of claim 1 wherein the solvent is an aqueous solution of 50 to 96 percent by volume ethanol.
Claim 6
Dependent Claim
24 words
A method of claim 4 wherein the prolamine is zein, and the concentration of zein in the solvent is 3 to 60 percent wt/volume.
Claim 7
Dependent Claim
16 words
A method of claim 1 wherein the solution has a pH of about 6.5 to 6.8.
Claim 8
Dependent Claim
27 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and from 5 to 45 percent by weight of an emulsified, physiologically compatible oil.
Claim 9
Dependent Claim
27 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and from 5 to 45 percent by weight of an emulsified, physiologically compatible oil.
Claim 10
Dependent Claim
24 words
A solution of claim 7 wherein said oil is selected from the group consisting of peanut oil, olive oil, poppyseed oil and almond oil.
Claim 11
Dependent Claim
18 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and an X-ray contrast medium.
Claim 12
Dependent Claim
18 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and an X-ray contrast medium.
Claim 13
Dependent Claim
18 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and a radioactive tracer substance.
Claim 14
Dependent Claim
18 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and a radioactive tracer substance.
Claim 15
Dependent Claim
17 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and a cytostatic agent.
Claim 16
Dependent Claim
17 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and a cytostatic agent.
Claim 17
Dependent Claim
17 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and an antimicrobial compound.
Claim 18
Dependent Claim
17 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and an antimicrobial compound.
Claim 19
Dependent Claim
18 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and a specific pancreas inhibitor.
Claim 20
Dependent Claim
18 words
An injectable embolization and occlusion solution comprising prolamine in a physiologically compatible solvent and a specific pancreas inhibitor.
Claim 21
Independent Claim
52 words
A method for occluding the vascular or duct system of a living organ by injecting into the organ at the site to be occluded a solution comprising 5 to 45 percent by wt/volume of zein in 50 to 96 percent by volume aqueous ethanol at a pH of about 6.5 to 6.8.
Claim 22
Independent Claim
52 words
A method for occluding the vascular or duct system of a living organ by injecting into the organ at the site to be occluded a solution comprising 5 to 45 percent by wt/volume of zein in 50 to 96 percent by volume aqueous ethanol at a pH of about 6.5 to 6.8.
Claim 23
Dependent Claim
20 words
A method of claim 14 wherein the solution has a viscosity of about 350 to 800 centipoise at 25° C.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-18 | 1984-11-17 | 1985-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-18 | 1988-11-17 | 1989-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-18 | 1992-11-17 | 1993-05-19 | $7700.00 | Window Closed / Lapsed |