US4260779A
Expired / Lapsed
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Oxothia compounds
Assignee: Novartis Corp
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Filing: 1979-11-09
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Granted: 1981-04-07
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Expires: 1999-11-09
Abstract
Abstract Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R 1 represents an organic radical bonded via a carbon atom and R 2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.
Inventors
- 👤 Raymond Bernasconi
- 👤 Pier G. Ferrini
- 👤 Richard Goschke
- 👤 Jacques Gosteli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:06
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/50; C07D333/52; C07D333/62; C07D333/68; C07D333/64; C07D333/70
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
92 words
An oxothia compound of the formula ##STR10## in which Ph represents 1,2-phenylene or 1,2-phenylene which is substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, X represents oxygen or sulphur, R 1 represents lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl cycloalkyl-lower alkyl, phenyl-lower alkyl or phenyl-lower alkyl which is substituted in the phenyl part by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, phenyl or phenyl which is substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, and R 2 represents hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
92 words
An oxothia compound of the formula ##STR10## in which Ph represents 1,2-phenylene or 1,2-phenylene which is substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, X represents oxygen or sulphur, R 1 represents lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl cycloalkyl-lower alkyl, phenyl-lower alkyl or phenyl-lower alkyl which is substituted in the phenyl part by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, phenyl or phenyl which is substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, and R 2 represents hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
78 words
A compound of the formula I as claimed in claim 1, in which Ph represents 1,2-phenylene which is optionally substituted by lower alkyl, lower alkoxy, halogen with an atomic number of up to 35 or trifluoromethyl, X represents oxygen, R 1 denotes phenyl which is optionally substituted by lower alkyl, lower alkoxy, halogen with an atomic number of up to 35, trifluoromethyl and/or nitro, and R 2 represents hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
67 words
A compound of the formula I as claimed in claim 1, in which Ph represents 1,2-phenylene which can optionally be substituted by lower alkyl, lower alkoxy and/or halogen with an atomic number of up to 35, X represents oxygen, R 1 denotes phenyl which is optionally substituted by lower alkyl, lower alkoxy and/or halogen with an atomic number of up to 35, and R 2 represents hydrogen.
Claim 5
Dependent Claim
20 words
A compound as claimed in claim 1 and being the N-(3-chlorophenyl)-2-oxo-2,3-dihydro-3-benzo[b]thiophenecarboxamide or a pharmaceutically acceptable salt thereof with a base.
Claim 6
Dependent Claim
20 words
A compound as claimed in claim 1 and being the N-(3-chlorophenyl)-5-chloro-2-oxo-2,3-dihydro-3-benzo[b]thiophenecarboxamide or a pharmaceutically acceptable salt thereof with a base.
Claim 7
Dependent Claim
20 words
A compound as claimed in claim 1 and being the N-(2-fluorophenyl)-2-oxo-2,3-dihydro-3-benzo[b]thiophenecarboxamide or a pharmaceutically acceptable salt thereof with a base.
Claim 8
Dependent Claim
20 words
A compound as claimed in claim 1 and being the N-phenyl-6-chloro-2-oxo-2,3-dihydro-3-benzo[b]thiophene-carboxamide or a pharmaceutically acceptable salt thereof with a base.
Claim 9
Dependent Claim
20 words
A compound as claimed in claim 1 and being the N-(3-chlorophenyl)-6-chloro-2-oxo-2,3-dihydro-3-benzo[b]thiophene-carboxamide or a pharmaceutically acceptable salt thereof with a base.
Claim 10
Dependent Claim
20 words
A compound as claimed in claim 1 and being the N-(2-fluorophenyl)-6-chloro-2-oxo-2,3-dihydro-3-benzo[b]thiophene-carboxamide or a pharmaceutically acceptable salt thereof with a base.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-06 | 1984-10-06 | 1985-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-06 | 1988-10-06 | 1989-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-06 | 1992-10-06 | 1993-04-07 | $7700.00 | Window Closed / Lapsed |