US4221779A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical composition for treating tropical diseases
Assignee: BTG International Ltd
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Filing: 1978-06-28
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Granted: 1980-09-09
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Expires: 1998-06-28
Abstract
Abstract A pharmaceutical composition of prolonged effect in the treating of Tropical Diseases comprises an organic nitrogen base drug which is effective against diseases such as malaria, dispersed in a polymeric matrix of a copolymer of the compound <IMAGE> and a comonomer which contains more than one functional group selected from hydroxy and carboxy groups.
Inventors
- 👤 Neil B. Graham
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:02
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
72 words
A pharmaceutical composition comprising therapeutically effective amount of a drug which is an organic compound containing a nitrogen atom and which is effective against a tropical disease, in admixture with a polymeric matrix of a copolymer of the compound of Formula I: ##STR6## with at least one comonomer having more than one functional group selected from the group consisting of hydroxyl and carboxyl groups, said polymeric matrix being biodegradable in the body.
Claim 2
Dependent Claim
72 words
A pharmaceutical composition comprising therapeutically effective amount of a drug which is an organic compound containing a nitrogen atom and which is effective against a tropical disease, in admixture with a polymeric matrix of a copolymer of the compound of Formula I: ##STR6## with at least one comonomer having more than one functional group selected from the group consisting of hydroxyl and carboxyl groups, said polymeric matrix being biodegradable in the body.
Claim 3
Dependent Claim
27 words
A pharmaceutical composition according to claim 1, in which the polymeric matrix is a copolymer of glycerol and the compound of Formula I defined in claim 1.
Claim 4
Dependent Claim
22 words
A pharmaceutical composition according to claim 2, in which the molar ratio of the compound of formula I to glycerol is 3:2.
Claim 5
Dependent Claim
35 words
A pharmaceutical composition comprising 10%(wt.) cycloguanil dispersed in a polymeric matrix of a copolymer formed from a mixture containing 17%(wt.) glycerol, 73.8%(wt.) of the compound having the following structural formula: ##STR7## and 0.2%(wt.) ferric chloride.
Claim 6
Dependent Claim
35 words
A pharmaceutical composition comprising 10%(wt.) cycloguanil dispersed in a polymeric matrix of a copolymer formed from a mixture containing 17%(wt.) glycerol, 73.8%(wt.) of the compound having the following structural formula: ##STR7## and 0.2%(wt.) ferric chloride.
Claim 7
Dependent Claim
35 words
A pharmaceutical composition comprising 10%(wt.) sulphadiazine dispersed in a polymeric matrix of a copolymer formed from a mixture containing 20%(wt.) glycerol, 69.8%(wt.) of the compound having the following structural formula: ##STR8## and 0.2%(wt.) ferric chloride.
Claim 8
Dependent Claim
35 words
A pharmaceutical composition comprising 10%(wt.) sulphadiazine dispersed in a polymeric matrix of a copolymer formed from a mixture containing 20%(wt.) glycerol, 69.8%(wt.) of the compound having the following structural formula: ##STR8## and 0.2%(wt.) ferric chloride.
Claim 9
Dependent Claim
35 words
A pharmaceutical composition comprising 30%(wt.) sulphadiazine dispersed in a polymeric matrix of a copolymer formed from a mixture containing 15%(wt.) glycerol, 54.8%(wt.) of the compound having the following structural formula: ##STR9## and 0.2%(wt.) ferric chloride.
Claim 10
Dependent Claim
35 words
A pharmaceutical composition comprising 30%(wt.) sulphadiazine dispersed in a polymeric matrix of a copolymer formed from a mixture containing 15%(wt.) glycerol, 54.8%(wt.) of the compound having the following structural formula: ##STR9## and 0.2%(wt.) ferric chloride.
Claim 11
Dependent Claim
35 words
A pharmaceutical composition comprising 30%(wt.) pyrimethamine dispersed in a polymeric matrix of a copolymer formed from a mixture containing 15%(wt.) glycerol, 54.7%(wt.) of the compound having the following structural formula: ##STR10## and 0.3%(wt.) ferric chloride.
Claim 12
Dependent Claim
35 words
A pharmaceutical composition comprising 30%(wt.) pyrimethamine dispersed in a polymeric matrix of a copolymer formed from a mixture containing 15%(wt.) glycerol, 54.7%(wt.) of the compound having the following structural formula: ##STR10## and 0.3%(wt.) ferric chloride.
Claim 13
Dependent Claim
76 words
A pharmaceutical composition comprising a therapeutically effective amount of a drug which is an organic compound containing a nitrogen atom and which is effective against a tropical disease in admixture with a polymeric matrix having a glass transition temperature above body temperature which is prepared by mixing the compound of Formula I: ##STR11## with glycerol in the presence of an acidic catalyst, adding said drug to the resulting mixture and then permitting said mixture to cure.
Claim 14
Dependent Claim
76 words
A pharmaceutical composition comprising a therapeutically effective amount of a drug which is an organic compound containing a nitrogen atom and which is effective against a tropical disease in admixture with a polymeric matrix having a glass transition temperature above body temperature which is prepared by mixing the compound of Formula I: ##STR11## with glycerol in the presence of an acidic catalyst, adding said drug to the resulting mixture and then permitting said mixture to cure.
Claim 15
Dependent Claim
23 words
A pharmaceutical composition according to claim 8 wherein the compound of formula I and glycerol are admixed in a molar ratio of 3:2.
Claim 16
Dependent Claim
14 words
A pharmaceutical composition according to claim 9 wherein the acidic catalyst is ferric chloride.
References Cited (Backward Citations)
US3318846A
Cited
US3316325A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-09 | 1984-03-10 | 1984-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-09 | 1988-03-10 | 1988-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-09 | 1992-03-10 | 1992-09-09 | $7700.00 | Window Closed / Lapsed |