US4217341A
Expired / Lapsed
US
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Composition and method for inhibiting the adherence of dental plaque-producing bacteria to smooth surfaces
Assignee: University of Louisville
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Filing: 1977-12-07
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Granted: 1980-08-12
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Expires: 1997-12-07
Abstract
Abstract A composition and method for inhibiting the adherence of dental plaque-producing bacteria to smooth surfaces including a lectin as an active ingredient thereof.
Inventors
- 👤 Richard P. Suddick
- 👤 Robert H. Staat
- 👤 Ronald J. Doyle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:06
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61Q; A61Q11/00
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
101 words
A composition for inhibiting the adherence of dental-plaque producing bacteria to a smooth surface including a carrier material and an effective quantity of a lectin, said lectin being of the type exemplified by the extract obtained by grinding the seed of a plant chosen from a group comprising Arachis hypogaea, Persea americana, Mangiferia indicia, Cucurbito pepo, or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of said bacteria to a value less than 50 percent as tested by the glass vial technique.
Claim 2
Dependent Claim
101 words
A composition for inhibiting the adherence of dental-plaque producing bacteria to a smooth surface including a carrier material and an effective quantity of a lectin, said lectin being of the type exemplified by the extract obtained by grinding the seed of a plant chosen from a group comprising Arachis hypogaea, Persea americana, Mangiferia indicia, Cucurbito pepo, or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of said bacteria to a value less than 50 percent as tested by the glass vial technique.
Claim 3
Dependent Claim
36 words
The composition of claim 1 wherein said lectin exhibits a chemical specificity with respect to a red blood cell or bacteria agglutination test to d-Galactose, (α-D-Galactose) 2 , L-Fucose, N-Acetylneuraminic Acid, basic peptides, or basic proteins.
Claim 4
Dependent Claim
44 words
The composition of claim 1 wherein said lectin exhibits the chemical specificities with respect to a red blood cell or bacteria agglutination test as does the lectin derived from the seed of either Arachis hypogaea, Persia, americana, Mangiferia indica, Cucurbito pepo, or Phaseolus vulgaris.
Claim 5
Dependent Claim
32 words
The composition of claim 1 wherein said lectin is derived from the seed of a plant chosen from the group comprising Arachis hypogaea, Persea, americana, Mangiferia indica, Cucurbito pepo, or Phaseolus vulgaris.
Claim 6
Dependent Claim
90 words
A dentifrice comprising a carrier material and an effective quantity of a lectin of the type exemplified by the extract obtained by grinding the seed of a plant chosen from the group comprising Arachis hypogaes, Persea americana, Mangiferia indicia, Cucurbito pepo, or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of bacteria of the dental-plaque-producing type to a value of less than 50 percent as tested by the glass vial technique.
Claim 7
Dependent Claim
90 words
A dentifrice comprising a carrier material and an effective quantity of a lectin of the type exemplified by the extract obtained by grinding the seed of a plant chosen from the group comprising Arachis hypogaes, Persea americana, Mangiferia indicia, Cucurbito pepo, or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of bacteria of the dental-plaque-producing type to a value of less than 50 percent as tested by the glass vial technique.
Claim 8
Dependent Claim
36 words
The dentifrice of claim 5 wherein said lectin exhibits a chemical specificity with respect to a red blood cell or bacteria agglutination test to D-Galactose, (α-D-Galactose) 2 , L-Fucose, N-Acetylneuraminic Acid, basic peptides, or basic proteins.
Claim 9
Dependent Claim
43 words
The dentifirce of claim 5 wherein said lectin exhibits the chemical specificities with respect to red blood cell or bacteria agglutination tests as does the lectin derived from the seed of either Arachis hypogaea, Persea americana, Mangiferia indica, Cucurbito pepo, or Phaseolus vulgaris.
Claim 10
Dependent Claim
32 words
The dentifrice of claim 5 wherein said lectin is derived from the seed of a plant chosen from the group comprising Arachis hypogaea, Persea americana, Mangiferia indica, Cucurbito pepo, or Phaseolus vulgaris.
Claim 11
Dependent Claim
100 words
A mouthwash for inhibiting the adherence of dental-plaque producing bacteria to a smooth surface including a liquid carrier material and an effective quantity of a lectin of the type exemplified by the extract obtained by grinding the seed of a plant chosen from the group comprising Arachis hypogaea, Persea americana, Mangiferia indicia, Cucurbito pepo, or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of dental plaque-producing bacteria to a value less than 50 percent as tested by the glass vial technique.
Claim 12
Dependent Claim
100 words
A mouthwash for inhibiting the adherence of dental-plaque producing bacteria to a smooth surface including a liquid carrier material and an effective quantity of a lectin of the type exemplified by the extract obtained by grinding the seed of a plant chosen from the group comprising Arachis hypogaea, Persea americana, Mangiferia indicia, Cucurbito pepo, or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of dental plaque-producing bacteria to a value less than 50 percent as tested by the glass vial technique.
Claim 13
Dependent Claim
36 words
The mouthwash of claim 9 wherein said lectin exhibits a chemical specificity with respect to a red blood cell or bacteria agglutination test to D-Galactose, (α-D-Galactose) 2 , L-Fucose, N-Acetylneuraminic acid, basic peptides, or basic proteins.
Claim 14
Dependent Claim
44 words
The mouthwash of claim 9 wherein said lectin exhibits the chemical specificities with respect to a red blood cell or bacteria agglutination test as does the lectin derived from the seed of either Arachis hypogaea, Persea, americana, Mangiferia, indicia, Cucurbito pepo, or Phaseolus vulgaris.
Claim 15
Dependent Claim
32 words
The mouthwash of claim 9 wherein said lectin is derived from the seed of a plant chosen from the group comprising Archais hypogaea, Persea americana, Mangiferia indica, Cucurbito pepo, or Phaseolus vulgaris.
Claim 16
Dependent Claim
102 words
A chewing gum for inhibiting the adherence of dental-plaque producing bacteria to a smooth surface including a carrier material and an effective quantity of a lectin, said lectin being of the type exemplified by the extract obtained by grinding the seed of a plant chosen from the group comprising Arachis hypogaea, Persea americana, Mangiferia indicia, Cucurbito pepo, or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of said bacteria to a value less than 50 percent as tested by the glass vial technique.
Claim 17
Dependent Claim
102 words
A chewing gum for inhibiting the adherence of dental-plaque producing bacteria to a smooth surface including a carrier material and an effective quantity of a lectin, said lectin being of the type exemplified by the extract obtained by grinding the seed of a plant chosen from the group comprising Arachis hypogaea, Persea americana, Mangiferia indicia, Cucurbito pepo, or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of said bacteria to a value less than 50 percent as tested by the glass vial technique.
Claim 18
Dependent Claim
37 words
The chewing gum of claim 13 wherein said lectin exhibits a chemical specificity with respect to a red blood cell or bacteria agglutination test to D-Galactose, (α-D-Galactose) 2 , L-Fucose, N-Acetylneuraminic Acid, basic peptides, or basic proteins.
Claim 19
Dependent Claim
45 words
The chewing gum of claim 13 wherein said lectin exhibits the chemical specificities with respect to a red blood cell or bacteria agglutination test as does the lectin derived from the seed of either Arachis hypogaea, Persia americana, Mangiferia indica, Cucurbito pepo, or Phaseolus vulgaris.
Claim 20
Dependent Claim
32 words
The composition of claim 13 wherein said lectin is derived from the seed of a plant chosen from the group comprising Arachis hypogaea, Persea americana, Mangiferia indica, Cucurbito pepo, or Phaseolus vulgaris.
Claim 21
Dependent Claim
30 words
A composition for inhibiting the adherence to a smooth surface of bacteria of the dental-plaque-producing type comprising an effective quantity of a lectin derived from the seed of Persea americana.
Claim 22
Dependent Claim
30 words
A composition for inhibiting the adherence to a smooth surface of bacteria of the dental-plaque-producing type comprising an effective quantity of a lectin derived from the seed of Persea americana.
Claim 23
Independent Claim
106 words
A method for inhibiting the adherence of bacteria of the dental-plaque-producing type to a smooth surface comprising the step of subjecting said bacteria to a composition containing an effective quantity of a lectin of the type exemplified by the extract obtained by grinding the seed of a plant chosen from the group comprising Arachis hypogaea, Persea americana, Mangiferia indicia, Cucurbito pepo or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of said bacteria to a value less than 50 percent as tested by the glass vial technique.
Claim 24
Independent Claim
106 words
A method for inhibiting the adherence of bacteria of the dental-plaque-producing type to a smooth surface comprising the step of subjecting said bacteria to a composition containing an effective quantity of a lectin of the type exemplified by the extract obtained by grinding the seed of a plant chosen from the group comprising Arachis hypogaea, Persea americana, Mangiferia indicia, Cucurbito pepo or Phaseolus vulgaris in a phosphate-saline buffer solution, said lectin being present in a concentration equivalent to a hemagglutination titer of 1:128, whereby said lectin reduces the adherence of said bacteria to a value less than 50 percent as tested by the glass vial technique.
Claim 25
Dependent Claim
29 words
The method of claim 18 wherein the ratio of lectin extract volume to the total volume of extract and bacteria solution is equal to or less than about 1:8.
References Cited (Backward Citations)
US3317386A
Cited
US3952092A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-12 | 1984-02-11 | 1984-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-12 | 1988-02-11 | 1988-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-12 | 1992-02-11 | 1992-08-12 | $7700.00 | Window Closed / Lapsed |