Patent US5309896A successfully refreshed from Google Patents.
US4213962A
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Artificial medical material with anticoagulative activity
Assignee: Individual
•
Filing: 1978-07-25
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Granted: 1980-07-22
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Expires: 1998-07-25
Abstract
Abstract An artificial medical material with an anticoagulative activity which comprises a carrier material, and heparin and antithrombin III co-immobilized thereon by a per se conventional procedure.
Inventors
- 👤 Yoshiharu Miura
- 👤 Sadayoshi Aoyagi
- 👤 Kazuhisa Miyamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:40
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K38/00; A61K38/005; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
19 words
An artificial medical material with anticoagulative activity which comprises a carrier material with heparin and antithrombin III co-immobilized thereon.
Claim 2
Dependent Claim
19 words
An artificial medical material with anticoagulative activity which comprises a carrier material with heparin and antithrombin III co-immobilized thereon.
Claim 3
Dependent Claim
17 words
An artificial medical material according to claim 1, wherein the carrier material is a water-insoluble high polymer.
Claim 4
Dependent Claim
15 words
An artificial medical material according to claim 2, wherein the water-insoluble high polymer is agarose.
Claim 5
Dependent Claim
16 words
An artificial medical material according to claim 2, wherein the water-insoluble high polymer is polyvinyl alcohol.
Claim 6
Dependent Claim
16 words
An artificial medical material according to claim 2, wherein the water-insoluble high polymer is polyhydroxyethyl methacrylate.
Claim 7
Dependent Claim
16 words
An artificial medical material according to claim 1, wherein the carrier material is activated carrier material.
Claim 8
Dependent Claim
16 words
An artificial medical material according to claim 6, wherein the carrier material is cyanogen-bromide-activated carrier material.
Claim 9
Dependent Claim
23 words
An artificial medical material according to claim 1, wherein the proportion of heparin and antithrombin III is from 1:1 to 10:1 (by weight).
Claim 10
Dependent Claim
35 words
An artificial medical material according to claim 1, wherein heparin and antithrombin III are immobilized on the carrier material, respectively, in amounts of from 1 to 50 mg per 1 g of the carrier material.
Claim 11
Dependent Claim
22 words
A method for prevention of coagulation of blood which comprises contacting the blood with an artificial medical material according to claim 1.
Claim 12
Dependent Claim
24 words
A method for inactivation of the Xa factor in blood which comprises contacting the blood with an artificial medical material according to claim 1.
Claim 13
Dependent Claim
45 words
In a method for prevention of coagulation of blood by contacting the blood with an artificial medical material bearing heparin immobilized thereon, the improvement wherein the artificial medical material also bears antithrombin III immobilized thereon so that the anticoagulative activity of heparin is greatly enhanced.
Claim 14
Dependent Claim
45 words
In a method for prevention of coagulation of blood by contacting the blood with an artificial medical material bearing heparin immobilized thereon, the improvement wherein the artificial medical material also bears antithrombin III immobilized thereon so that the anticoagulative activity of heparin is greatly enhanced.
Claim 15
Dependent Claim
17 words
A combination of immobilized heparin and an anticoagulative-activity-enhancing amount of immobilized antithrombin III on a carrier material.
Claim 16
Dependent Claim
17 words
A combination of immobilized heparin and an anticoagulative-activity-enhancing amount of immobilized antithrombin III on a carrier material.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-07-22 | 1984-01-21 | 1984-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-07-22 | 1988-01-21 | 1988-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-07-22 | 1992-01-21 | 1992-07-22 | $7700.00 | Window Closed / Lapsed |