US4203440A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device having variable volume chamber for dispensing useful agent
Assignee: Alza Corp
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Filing: 1978-10-23
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Granted: 1980-05-20
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Expires: 1998-10-23
Abstract
Abstract A self-powered device is disclosed for delivering a useful agent. The device comprises (1) a housing member, (2) a variable volume chamber storing a useful agent and having a passageway for delivering the agent in the housing, and (3) a pressure generating member comprising a semipermeable polymer having a cross-linked hydrophilic polymer dispersed therein positioned between the housing and the chamber. In operation, when the device is in a fluid environment, fluid from the environment enters the housing and is imbibed by the hydrophilic polymer into the generator, causing the generator to enlarge and apply pressure against the chamber, thereby decreasing the volume of the chamber and simultaneously dispensing agent through the passageway from the device at a controlled rate over a prolonged period of time. An article of manufacture also is disclosed which consists of a pressure generating member manufactured as a film useful for making a dispensing device.
Inventors
- 👤 Felix Theeuwes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 18:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/009
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
171 words
A device for delivering a useful agent to an environment of use, comprising: (a) a useful agent; (b) a housing having a shape retaining wall defining an internal space, the housing having at least one opening connecting the space with the exterior of the device; (c) a variable volume chamber in the housing, said chamber comprising a flexible wall surrounding a reservoir for storing the agent, and a passageway for delivering the agent from the chamber to the exterior of the device; (d) a pressure generating member in the housing positioned between the housing and the chamber, said member formed of a semipermeable polymer having therein a swellable, insoluble hydrophilic polymer; and, (e) wherein, in operation when the device is in the environment of use, the member imbibes fluid admitted into the device, causing the member to expand, generate and exert pressure on the chamber which decreases the volume of the chamber thereby delivering agent through the passageway from the device at a controlled rate over a prolonged period of time.
Claim 2
Independent Claim
171 words
A device for delivering a useful agent to an environment of use, comprising: (a) a useful agent; (b) a housing having a shape retaining wall defining an internal space, the housing having at least one opening connecting the space with the exterior of the device; (c) a variable volume chamber in the housing, said chamber comprising a flexible wall surrounding a reservoir for storing the agent, and a passageway for delivering the agent from the chamber to the exterior of the device; (d) a pressure generating member in the housing positioned between the housing and the chamber, said member formed of a semipermeable polymer having therein a swellable, insoluble hydrophilic polymer; and, (e) wherein, in operation when the device is in the environment of use, the member imbibes fluid admitted into the device, causing the member to expand, generate and exert pressure on the chamber which decreases the volume of the chamber thereby delivering agent through the passageway from the device at a controlled rate over a prolonged period of time.
Claim 3
Dependent Claim
37 words
The device for delivering the useful agent to an environment of use according to claim 1, wherein the passageway of the variable volume chamber extends through the opening in the housing to the exterior of the device.
Claim 4
Dependent Claim
26 words
The device for delivering the useful agent to an environment of use according to claim 1, wherein the swellable hydrophilic polymer, is an ion exchange resin.
Claim 5
Dependent Claim
37 words
The device for delivering the useful agent to an environment of use according to claim 1, wherein the housing has an opening for the passageway and at least an additional opening for letting fluid into the housing.
Claim 6
Dependent Claim
20 words
The device for delivering the useful agent according to claim 1, wherein the housing is manufactured from a microporous polymer.
Claim 7
Dependent Claim
51 words
The device for delivering the useful agent to an environment of use according to claim 1, wherein the chamber is formed of a member selected from the group consisting of natural rubber, gutta percha, cyclised rubber, isoprene rubber, butadiene rubber, styrene-butadiene copolymeric rubber, nitrile rubber, chloroprene rubber and ethylenepropylene copolymeric rubber.
Claim 8
Dependent Claim
45 words
The device for delivering the useful agent to an environment of use according to claim 1, wherein the housing is formed of a member selected from the group consisting essentially of polyolefin, polyethylene, polypropylene, polytetrafluoroethylene, polyamide, polyformaldehyde, polystyrene, polycarbonate, polyacrylate, polymethacrylate, polyacrylonitrile, and polyvinyl chloride.
Claim 9
Dependent Claim
22 words
The device for delivering the useful agent to an environment of use according to claim 1, wherein the agent is a drug.
Claim 10
Dependent Claim
62 words
The device for delivering the useful agent according to claim 1, wherein the environment is a biological environment, and the agent is a drug selected from the group consisting of locally and systemically acting gastrointestinal, central nervous system, hypnotic, sedative, psychic energizer, tranquilizer, anticonvulsant, antiparkinson, muscle relaxant, analgesic, antipyretic, anti-inflammatory, anesthetic, antispasmodic, antimicrobial, antiviral, antiulcer, hormonal, sympathomimetic, diuretic, hypoglycemic and anticontraceptive drugs.
Claim 11
Dependent Claim
26 words
The device for delivering the useful agent according to claim 1, wherein the agent in the chamber is a drug mixed with a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
32 words
The device for delivering the useful agent according to claim 1, wherein the passageway is projected through the opening in the housing, with said passageway formed by the wall of the chamber.
Claim 13
Dependent Claim
33 words
The device for delivering the useful agent according to claim 1, wherein the passageway is connected to a tube that extends through the opening in the housing for delivering agent from the device.
Claim 14
Dependent Claim
57 words
The device for delivering the useful agent according to claim 1, wherein the pressure-generating member comprises a semipermeable polymer selected from the group consisting of a cellulose ester, cellulose ether, cellulose acylate, cellulose diacylate, cellulose triacylate, and polyurethane, having dispersed therein particles of a member selected from the group consisting of a cross-linked anion and cation resins.
Claim 15
Dependent Claim
91 words
The device for delivering the useful agent according to claim 1, wherein the swellable, insoluble hydrophilic polymer is an ion exchange resin selected from the group consisting essentially of cross-linked styrene-divinylbenzene copolymer, cross-linked basic acidic cation resin, cross-linked basic anion resin, anion resin--C 6 H 4 --CH 2 N(CH 3 ) 3 Cl, anion resin--C 6 H 4 --CH 2 N(CH 3 ) 3 (C 2 H 5 --OH)Cl, cation resin--C 6 H 4 --SO 3 H, and acid cation resin--C 6 H 4 --CH 2 N(CH 2 COOH) 2 .
Claim 16
Dependent Claim
34 words
The device for the delivery of the useful agent according to claim 1, wherein the swellable, insoluble hydrophilic polymer is present in the form of particles and the particles are bead and spherical shaped.
Claim 17
Dependent Claim
19 words
The device for delivery of the useful agent according to claim 13 wherein the semipermeable polymer contains a plasticizer.
Claim 18
Dependent Claim
24 words
The device for delivering the useful agent to an environment of use according to claim 1, wherein the swellable, insoluble polymer is lightly cross-linked.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-05-20 | 1983-11-19 | 1984-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-05-20 | 1987-11-19 | 1988-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-05-20 | 1991-11-19 | 1992-05-20 | $7700.00 | Window Closed / Lapsed |