US4199512A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compounds for alleviating hypertension
Assignee: ER Squibb and Sons LLC
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Filing: 1978-09-18
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Granted: 1980-04-22
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Expires: 1998-09-18
Abstract
Abstract A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
Inventors
- 👤 Miguel A. Ondetti
- 👤 David W. Cushman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:25
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
59 words
A compound of the formula ##STR15## and salts thereof, wherein R 6 is hydrogen, formyl, or lower alkyl; R 7 is hydrogen, halogen, hydroxy or lower alkoxy; R 2 , R 3 and R 4 each is hydrogen, lower alkyl, or phenyllower alkylene; R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR16## and n is 0, 1 or 2.
Claim 2
Dependent Claim
59 words
A compound of the formula ##STR15## and salts thereof, wherein R 6 is hydrogen, formyl, or lower alkyl; R 7 is hydrogen, halogen, hydroxy or lower alkoxy; R 2 , R 3 and R 4 each is hydrogen, lower alkyl, or phenyllower alkylene; R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR16## and n is 0, 1 or 2.
Claim 3
Dependent Claim
44 words
A compound of the formula ##STR17## or salt thereof, wherein n is 0; R 1 is indol-3-yl-lower alkylene; R 2 , R 3 and R 4 each is hydrogen, lower alkyl or phenyl-lower alkylene; and R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR18##
Claim 4
Dependent Claim
44 words
A compound of the formula ##STR17## or salt thereof, wherein n is 0; R 1 is indol-3-yl-lower alkylene; R 2 , R 3 and R 4 each is hydrogen, lower alkyl or phenyl-lower alkylene; and R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR18##
Claim 5
Dependent Claim
45 words
A compound of the formula ##STR19## or salt thereof, wherein n is 1; R 1 is indol-3-yl-lower alkylene; R 2 and R 3 each is hydrogen, lower alkyl, or phenyl-lower alkylene; R 4 is hydrogen; and R 5 is hydrogen, lower alkanoyl, benzoyl, or ##STR20##
Claim 6
Dependent Claim
45 words
A compound of the formula ##STR19## or salt thereof, wherein n is 1; R 1 is indol-3-yl-lower alkylene; R 2 and R 3 each is hydrogen, lower alkyl, or phenyl-lower alkylene; R 4 is hydrogen; and R 5 is hydrogen, lower alkanoyl, benzoyl, or ##STR20##
Claim 7
Dependent Claim
44 words
A compound of the formula ##STR21## or salt thereof, wherein n is 2; R 1 is indol-3-yl-lower alkylene; R 2 , R 3 and R 4 each is hydrogen, lower alkyl, or phenyl-lower alkylene; and R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR22##
Claim 8
Dependent Claim
44 words
A compound of the formula ##STR21## or salt thereof, wherein n is 2; R 1 is indol-3-yl-lower alkylene; R 2 , R 3 and R 4 each is hydrogen, lower alkyl, or phenyl-lower alkylene; and R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR22##
Claim 9
Dependent Claim
30 words
A compound as in claim 3 wherein R 1 is indol-3-yl-lower alkylene; R 2 and R 5 each is hydrogen; and R 3 is hydrogen, lower alkyl or phenyl-lower alkylene.
Claim 10
Dependent Claim
21 words
A compound as in claim 1 wherein the substituent R 7 is at the 5- or 6-position of the indolyl group.
Claim 11
Dependent Claim
27 words
A compound as in claim 3 wherein R 2 , R 3 and R 4 each is hydrogen and R 5 is benzoyl, having the name N-(3-benzoylthiopropanoyl)tryptophan.
Claim 12
Dependent Claim
25 words
A compound as in claim 3 wherein R 2 , R 3 , R 4 and R 5 each is hydrogen, having the name N-(3-mercaptopropanoyl)tryptophan.
Claim 13
Dependent Claim
27 words
A compound as in claim 3 wherein R 2 , R 4 and R 5 each is hydrogen and R 3 is methyl, having the name N-(3-mercapto-2-methylpropanoyl)tryptophan.
Claim 14
Dependent Claim
27 words
A compound as in claim 2 wherein R 2 , R 4 and R 5 each is hydrogen and R 3 is methyl, having the name N-(2-mercaptopropanoyl)tryptophan.
Claim 15
Dependent Claim
25 words
A compound as in claim 2 wherein R 2 , R 3 , R 4 and R 5 each is hydrogen, having the name N-(2-mercaptoacetyl)-tryptophan.
Claim 16
Dependent Claim
33 words
A compound as in claim 6 wherein R 1 is 5-methoxyindol-3-ylmethyl; R 2 , R 3 , R 4 and R 5 each is hydrogen; and n is 1, having the name N-(3-mercapto-1-oxopropyl)-5-methoxytryptophan.
Claim 17
Dependent Claim
33 words
A compound as in claim 6 wherein R 1 is 5-bromoindol-3-ylmethyl, R 2 , R 3 , R 4 and R 5 each is hydrogen, and n is 1, having the name 5-bromo-N-(3-mercapto-1-oxopropyl)tryptophan.
Claim 18
Dependent Claim
33 words
A compound as in claim 6 wherein R 1 is 1-methylindol-3-ylmethyl, R 2 , R 3 , R 4 and R 5 each is hydrogen, and n is 1, having the name N-(3-mercapto-1-oxopropyl)-1-methyltryptophan.
Claim 19
Dependent Claim
33 words
A compound as in claim 6 wherein R 1 is 5-hydroxyindol-3-ylmethyl, R 2 , R 3 , R 4 and R 5 each is hydrogen, and n is 1, having the name 5-hydroxy-N-(3-mercapto-1-oxopropyl)tryptophan.
Claim 20
Dependent Claim
33 words
A compound as in claim 6 wherein R 1 is 6-fluoroindol-3-ylmethyl, R 2 , R 3 , R 4 and R 5 each is hydrogen, and n is 1, having the name 6-fluoro-N-(3-mercapto-1-oxopropyl)tryptophan.
Claim 21
Dependent Claim
33 words
A compound as in claim 6 wherein R 1 is 1-formylindol-3-ylmethyl, R 2 , R 3 , R 4 and R 5 each is hydrogen, and n is 1, having the name 1-formyl-N-(3-mercapto-1-oxopropyl)tryptophan.
Claim 22
Dependent Claim
11 words
A compound as in claim 1 wherein R 5 is ##STR23##
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-22 | 1983-10-22 | 1984-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-22 | 1987-10-22 | 1988-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-22 | 1991-10-22 | 1992-04-22 | $7700.00 | Window Closed / Lapsed |