US4191176A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intralenticular cataract surgery
Assignee: Novo Laboratories Inc
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Filing: 1977-08-23
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Granted: 1980-03-04
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Expires: 1997-08-23
Abstract
Abstract An enzymatic intralenticular cataract treatment for removal of nuclear cortical and subcapsular regions of the cataractous lens through enzymatic digestion thereof which comprises introduction of a concentrated solution of a trypsin enzyme into the nuclear and cortical regions of a cataractous lens, and after enzymatic digestion removing the liquefied cataractous material. The procedure allows subsequent removal of the nuclear, cortical and subcapsular portions of a cataractous lens through a very tiny incision in the eye and lens capsule, leaving all other structures within the eye intact. Bovine and porcine trypsins are preferred.
Inventors
- 👤 Joseph Spina
- 👤 Michael K. Weibel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:28
CPC Classifications
A; A61; A61F; A61F9/00; A61F9/007; A61F9/00736; A61M; A61M2210/00; A61M2210/06; A61M2210/0612
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
42 words
A method for enzymatically treating cataracts in vivo which comprises injecting a concentrated solution of a trypsin directly into the lens of an eye, then allowing enzymatic digestion of the lens to take place and thereafter removing the enzyme digested lens material.
Claim 2
Independent Claim
42 words
A method for enzymatically treating cataracts in vivo which comprises injecting a concentrated solution of a trypsin directly into the lens of an eye, then allowing enzymatic digestion of the lens to take place and thereafter removing the enzyme digested lens material.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein a tracking indicator is included in the enzyme solution.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the trypsin is bovine trypsin.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the trypsin is porcine trypsin.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein said removal is by irrigation and aspiration.
Claim 7
Dependent Claim
12 words
The method of claim 1 wherein the trypsin concentration is 0.1-10 mg/ml.
Claim 8
Dependent Claim
23 words
The method of claim 1 wherein the trypsin concentration is 0.1-10 mg/ml and wherein 0.01-1.0% w/v of fluorescein is present in the solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-04 | 1983-09-03 | 1984-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-04 | 1987-09-03 | 1988-03-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-04 | 1991-09-03 | 1992-03-04 | $7700.00 | Window Closed / Lapsed |