US4181708A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Rumen-stable pellets
Assignee: Adisseo France SAS
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Filing: 1978-07-24
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Granted: 1980-01-01
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Expires: 1998-07-24
Abstract
Abstract Pellets adapted to be orally administered to ruminants are disclosed. The pellets have a core comprising a nutrient and/or medicament, and a coating which protects the core in the environment of the rumen is also provided to allow utilization of the core in the abomasum and/or intestine. The coating comprises a polymeric matrix which is resistant to the mildly acidic environment of the rumen, and a hydrophobic substance and a flake material dispersed throughout the continuous matrix. The core may contain a neutralizer if desired. The continuity of the polymeric matrix is destroyed in the more acidic environment of the abomasum.
Inventors
- 👤 Clarence C. Dannelly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:54
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/501; A23; A23K; A23K20/00; A23K20/10; A23K20/105; A23K20/142; A23K40/00; A23K40/30; A23K40/35; A61K9/5015; A61K9/5021; A61K9/5026; A61K9/5036; A61K9/5042
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
259 words
A pellet adapted for oral administration to a ruminant comprising a core material beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a physiologically acceptable film-forming polymeric material comprising a polymer, copolymer or mixture thereof having a molecular weight of about 5000-300,000, said polymeric material having basic amino groups the nitrogen content of which constitutes between about 2 and about 14% by weight, of the polymeric material, (b) from about 5 to 50%, based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from the group consisting of waxes, resins, polymers, fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, and (c) from about 10 to 200%, based on the weight of said polymeric material, of a physiologically acceptable flake material dispersed in said polymeric material, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, and said coating making up about 5 to about 50% of the weight of said pellet, and having a sticking temperature of at least about 50° C.
Claim 2
Dependent Claim
259 words
A pellet adapted for oral administration to a ruminant comprising a core material beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a physiologically acceptable film-forming polymeric material comprising a polymer, copolymer or mixture thereof having a molecular weight of about 5000-300,000, said polymeric material having basic amino groups the nitrogen content of which constitutes between about 2 and about 14% by weight, of the polymeric material, (b) from about 5 to 50%, based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from the group consisting of waxes, resins, polymers, fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, and (c) from about 10 to 200%, based on the weight of said polymeric material, of a physiologically acceptable flake material dispersed in said polymeric material, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, and said coating making up about 5 to about 50% of the weight of said pellet, and having a sticking temperature of at least about 50° C.
Claim 3
Dependent Claim
45 words
A pellet according to claim 1 wherein said polymeric material comprises at least one polymer selected from the group consisting of cellulose propionate morpholinobutyrate, and polymers, copolymers and blends of polymers selected from the group consisting of acrylonitrile, vinyl pyridine, styrene, methacrylate and methyl methacrylate.
Claim 4
Dependent Claim
55 words
A pellet according to claim 1 wherein said hydrophobic material is selected from the group consisting of fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group.
Claim 5
Dependent Claim
93 words
A pellet according to claim 1 wherein said polymeric material comprises a polymer, copolymer or blend of polymers derived at least in part from monomers selected from the group consisting of 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine and 2-ethyl-5-vinylpyridine and said hydrophobic material is selected from the group consisting of fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000.
Claim 6
Dependent Claim
32 words
A pellet according to claim 4 wherein said core material is selected from the group consisting of L or DL mixtures of isomers of alanine, arginine, methionine, tyrosine, phenylalanine, lysine and glycose.
Claim 7
Dependent Claim
24 words
A pellet according to claim 4 wherein said core material is selected from the group consisting of glucose, bacitracin, thyrotropin releasing factor and inositol.
Claim 8
Dependent Claim
17 words
A pellet according to claim 4 wherein said polymeric material is a copolymer of 2-methyl-5-vinylpyridine and styrene.
Claim 9
Dependent Claim
23 words
A pellet according to claim 6 wherein said polymeric material is a copolymer consisting essentially of about 80% 2-methyl-5-vinylpyridine and about 20% styrene.
Claim 10
Dependent Claim
13 words
A pellet according to claim 4 wherein said hydrophobic material is aluminum oleate.
Claim 11
Dependent Claim
13 words
A pellet according to claim 4 wherein said hydrophobic material is stearic acid.
Claim 12
Dependent Claim
13 words
A pellet according to claim 4 wherein said hydrophobic material is dimer acid.
Claim 13
Dependent Claim
24 words
A pellet according to claim 4 wherein said flake material is selected from the group consisting of aluminum flake, talc, graphite, and ground mica.
Claim 14
Dependent Claim
14 words
A pellet according to claim 1 wherein said polymeric material is cellulose propionate morpholinobutyrate.
Claim 15
Dependent Claim
93 words
A pellet according to claim 1 wherein said polymeric material comprises a polymer, copolymer or blend of polymers derived at least in part from monomers selected from the group consisting of 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine and 2-ethyl-5-vinylpyridine and said hydrophobic material is selected from the group consisting of fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polycarboxylic acids having a ratio of from 12 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000.
Claim 16
Dependent Claim
230 words
A composition adapted for use in coating pellets orally administrable to a ruminant which protects the core material in the rumen and releases it in the abomasum comprising (a) a physiologically acceptable film-forming polymeric material comprising a polymer, copolymer or mixture thereof having a molecular weight of about 5000-300,000, said polymeric material having basic amino groups the nitrogen content of which constitutes between about 2 and about 14% by weight, of the polymeric material, (b) from about 5 to 50%, based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from the group consisting of waxes, resins, polymers, fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of 400 to 1000, and (c) from about 10 to about 200%, based on the weight of said polymeric material, of a physiologically acceptable flake material dispersed in said polymeric material, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said coating having a sticking temperature of at least about 50° C.
Claim 17
Dependent Claim
230 words
A composition adapted for use in coating pellets orally administrable to a ruminant which protects the core material in the rumen and releases it in the abomasum comprising (a) a physiologically acceptable film-forming polymeric material comprising a polymer, copolymer or mixture thereof having a molecular weight of about 5000-300,000, said polymeric material having basic amino groups the nitrogen content of which constitutes between about 2 and about 14% by weight, of the polymeric material, (b) from about 5 to 50%, based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from the group consisting of waxes, resins, polymers, fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of 400 to 1000, and (c) from about 10 to about 200%, based on the weight of said polymeric material, of a physiologically acceptable flake material dispersed in said polymeric material, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said coating having a sticking temperature of at least about 50° C.
Claim 18
Dependent Claim
17 words
A composition according to claim 15 wherein said polymeric material is a copolymer of 2-methyl-5-vinylpyridine and styrene.
Claim 19
Dependent Claim
23 words
A composition according to claim 15 wherein said polymeric material is a copolymer consisting essentially of about 80% 2-methyl-5-vinylpyridine and about 20% styrene.
Claim 20
Dependent Claim
13 words
A composition according to claim 15 wherein said hydrophobic material is aluminum oleate.
Claim 21
Dependent Claim
13 words
A composition according to claim 15 wherein said hydrophobic material is stearic acid.
Claim 22
Dependent Claim
13 words
A composition according to claim 15 wherein said hydrophobic material is dimer acid.
Claim 23
Dependent Claim
25 words
A composition according to claim 15 wherein said flake material is selected from the group consisting of metal flake, mineral flake, and crosslinked organic polymer.
Claim 24
Dependent Claim
24 words
A composition according to claim 21 wherein said flake material is selected from the group consisting of aluminum flake, talc, graphite, and ground mica.
Claim 25
Dependent Claim
207 words
A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.68, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a film-forming copolymer of about 80% 2-methyl-5-vinylpyridine and about 20% styrene by weight, (b) from about 2 to about 40% based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from aluminum oleate, dimer acid, stearic acid and oleic acid, and (c) from about 10 to about 200%, based on the weight of said polymeric material, of at least one physiologically acceptable flake material dispersed in said polymeric material selected from the group consisting of talc, aluminum flake and graphite, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said coating making up about 5 to about 50% of the weight of said pellet, and having a sticking temperature of at least about 50° C.
Claim 26
Dependent Claim
207 words
A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.68, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a film-forming copolymer of about 80% 2-methyl-5-vinylpyridine and about 20% styrene by weight, (b) from about 2 to about 40% based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from aluminum oleate, dimer acid, stearic acid and oleic acid, and (c) from about 10 to about 200%, based on the weight of said polymeric material, of at least one physiologically acceptable flake material dispersed in said polymeric material selected from the group consisting of talc, aluminum flake and graphite, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said coating making up about 5 to about 50% of the weight of said pellet, and having a sticking temperature of at least about 50° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-31 | 1983-07-02 | 1984-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-31 | 1987-07-02 | 1988-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-31 | 1991-07-02 | 1992-01-01 | $7700.00 | Window Closed / Lapsed |