US4176177A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhibition of bone resorption
Assignee: Rush Presbyterian St Lukes Medical Center
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Filing: 1978-11-16
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Granted: 1979-11-27
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Expires: 1998-11-16
Abstract
Abstract A method for regulating bone resorption wherein the bone is exposed to an effective amount of a composition of matter obtained from avascular or poorly vascularized tissue by extracting the tissue with an aqueous extraction medium which includes a solute which does not irreversibly denature the proteinaceous matter to be extracted and recovering from the aqeuous extract substances having molecular weight below about 50,000.
Inventors
- 👤 Klaus E. Kuettner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:03
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/24; A61K35/32; A61K35/34; A61K35/44
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
89 words
A method for regulating bone resorption comprising exposing the bone to an effective amount of a composition of matter obtained from avascular or poorly vascularized tissue by extracting the tissue with an aqueous extraction medium which includes a solute which does not irreversibly denature the proteinaceous matter to be extracted, separating the resultant aqueous extract from the tissue, recovering from the aqueous extract substances having a molecular weight below about 50,000, and treating the fraction of aqueous extract having a molecular weight below about 50,000 to remove salts therefrom.
Claim 2
Independent Claim
89 words
A method for regulating bone resorption comprising exposing the bone to an effective amount of a composition of matter obtained from avascular or poorly vascularized tissue by extracting the tissue with an aqueous extraction medium which includes a solute which does not irreversibly denature the proteinaceous matter to be extracted, separating the resultant aqueous extract from the tissue, recovering from the aqueous extract substances having a molecular weight below about 50,000, and treating the fraction of aqueous extract having a molecular weight below about 50,000 to remove salts therefrom.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein the tissue comprises cartilage.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the tissue comprises blood vessel walls.
Claim 5
Dependent Claim
10 words
The method of claim 1 wherein the tissue comprises cornea.
Claim 6
Dependent Claim
10 words
The method of claim 1 wherein the tissue comprises dentin.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein the tissue comprises heart valve.
Claim 8
Dependent Claim
10 words
The method of claim 1 wherein the tissue comprises vitreous.
Claim 9
Dependent Claim
10 words
The method of claim 1 wherein the tissue comprises lens.
Claim 10
Dependent Claim
11 words
The method of claim 1 wherein the tissue comprises synovial fluid.
Claim 11
Dependent Claim
22 words
The method of claim 1 wherein substances having a molecular weight between about 2,000 and 50,000 are recovered from the aqueous extract.
References Cited (Backward Citations)
US4042457A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-26 | 1983-05-28 | 1983-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-26 | 1987-05-28 | 1987-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-26 | 1991-05-28 | 1991-11-27 | $7700.00 | Window Closed / Lapsed |