US4158707A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Parenteral preparations
Assignee: Hoffmann La Roche Inc
•
Filing: 1977-07-08
•
Granted: 1979-06-19
•
Expires: 1997-07-08
Abstract
Abstract Aqueous vehicles for insoluble or sparingly soluble medicaments suitable for parenteral administration are disclosed. The subject vehicles contain, in addition to pharmaceutical adjunct materials to render them isotonic, preserve them and the like, a micelle forming agent comprising cholic acid or a derivative thereof in combination with a lipoid.
Inventors
- 👤 Hans Steffen
- 👤 Dieter Schmidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:29
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/107; A61K9/1075
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
47 words
An aqueous pharmaceutical preparation suitable for parenteral administration comprising a benzodiazepine, a phosphatide and a micelle forming agent selected from the group consisting of cholic acid, deoxycholic acid, glycodeoxycholic acid, taurodeoxycholic acid, chenocleoxycholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, glycocholic acid, taurocholic acid and pharmaecutically acceptable salts thereof.
Claim 2
Dependent Claim
47 words
An aqueous pharmaceutical preparation suitable for parenteral administration comprising a benzodiazepine, a phosphatide and a micelle forming agent selected from the group consisting of cholic acid, deoxycholic acid, glycodeoxycholic acid, taurodeoxycholic acid, chenocleoxycholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, glycocholic acid, taurocholic acid and pharmaecutically acceptable salts thereof.
Claim 3
Dependent Claim
19 words
A preparation in accordance with claim 1 additionally containing an isotonic effective amount of a suitable pharmaceutical isotonizing agent.
Claim 4
Dependent Claim
26 words
A preparation in accordance with claim 1 wherein said micelle forming agent is selected from the group consisting of cholic acid, glycocholic acid and taurocholic acid.
Claim 5
Dependent Claim
13 words
A preparation in accordance with claim 1 wherein said phosphatide in a phosphatidylcholine.
Claim 6
Dependent Claim
26 words
A preparation in accordance with claim 1 wherein the ratio between said micelle forming agent and said lipoid is between from about 0.1:1 to about 2:1.
Claim 7
Dependent Claim
26 words
A preparation in accordance with claim 5 wherein the ratio between said micelle forming agent and said lipoid is between from about 0.8:1 to about 1.5:1.
Claim 8
Dependent Claim
15 words
A preparation in accordance with claim 1 wherein said micelle forming agent is glycocholic acid.
References Cited (Backward Citations)
GB706607A
Cited
US3044931A
Cited
US3197368A
Cited
US3714352A
Cited
US3900561A
Cited
US3917830A
Cited
US4017616A
Cited
US4005190A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-06-18 | 1982-12-18 | 1983-06-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-06-18 | 1986-12-18 | 1987-06-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-06-18 | 1990-12-18 | 1991-06-19 | $7700.00 | Window Closed / Lapsed |