US4153688A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Trifluoromethylated oligopeptides
Assignee: Synthelabo SA
•
Filing: 1978-02-09
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Granted: 1979-05-08
•
Expires: 1998-02-09
Abstract
Abstract A compound having the formula <IMAGE> wherein (1) -X-Y- is -L-Ala-L-Ala- and R is H, m-NO2, m-CF3, p-Cl, p-NO2, p-CF3, p-OCH3, p-CH(CH3)2, p-CN or p-COOH, (2) -X-Y- is -L-Lys-L-Ala- and R is H, p-CF3, p-CH3+L, p-CH(CH3)2, <IMAGE> or p-COCH3 (3) -X-Y- is <IMAGE> AND R is H, or (4) -X-Y- is -L-Lys-L-Lys or L-Ala-L-Lys and R is p-CF3.
Inventors
- 👤 Jean-Luc Dimicoli
- 👤 Camille G. Wermuth
- 👤 Joseph G. Bieth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:13
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06191; A; A61; A61P; A61P11/00; A61K; A61K38/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
104 words
Compounds of formula: ##STR62## in which the couple --X--Y-- represents: either the sequence -L-Ala-L-Ala, in which case R designates: a hydrogen atom; a nitro or trifluoromethyl group in the meta position; or a chlorine atom or a nitro, trifluoromethyl, methoxy, isopropyl, cyano or carboxyl group in the para position; or the sequence -L-Lys-L-Ala-, in which case R designates: a hydrogen atom; or a trifluoromethyl, methyl, isopropyl, N,N-dimethylamino or acetyl group in the para position; or the sequence ##STR63## in which case R designates a hydrogen atom; or the sequence -L-Lys-L-Lys or -L-Ala-L-Lys-, in which case R represents a trifluoromethyl group in the para position.
Claim 2
Dependent Claim
104 words
Compounds of formula: ##STR62## in which the couple --X--Y-- represents: either the sequence -L-Ala-L-Ala, in which case R designates: a hydrogen atom; a nitro or trifluoromethyl group in the meta position; or a chlorine atom or a nitro, trifluoromethyl, methoxy, isopropyl, cyano or carboxyl group in the para position; or the sequence -L-Lys-L-Ala-, in which case R designates: a hydrogen atom; or a trifluoromethyl, methyl, isopropyl, N,N-dimethylamino or acetyl group in the para position; or the sequence ##STR63## in which case R designates a hydrogen atom; or the sequence -L-Lys-L-Lys or -L-Ala-L-Lys-, in which case R represents a trifluoromethyl group in the para position.
Claim 3
Dependent Claim
29 words
A compound having the formula ##STR64## wherein R is H, p-CF 3 , p-CH 3 , p-CH(CH 3 ) 2 , p-N(CH 3 ) 2 or p-COCH 3 .
Claim 4
Dependent Claim
29 words
A compound having the formula ##STR64## wherein R is H, p-CF 3 , p-CH 3 , p-CH(CH 3 ) 2 , p-N(CH 3 ) 2 or p-COCH 3 .
Claim 5
Dependent Claim
10 words
A compound according to claim 2 having the formula ##STR65##
Claim 6
Dependent Claim
10 words
A compound according to claim 2 having the formula ##STR66##
Claim 7
Dependent Claim
10 words
A compound according to claim 2 having the formula ##STR67##
Claim 8
Dependent Claim
10 words
A compound according to claim 2 having the formula ##STR68##
Claim 9
Dependent Claim
10 words
A compound according to claim 2 having the formula ##STR69##
Claim 10
Dependent Claim
34 words
A compound having the formula ##STR70## wherein R is H, m-NO 2 , m-CF 3 , p-Cl, p-NO 2 , p-CF 3 , p-OCH 3 , p-CH(CH 3 ) 2 , p-CN or p-COOH.
Claim 11
Dependent Claim
34 words
A compound having the formula ##STR70## wherein R is H, m-NO 2 , m-CF 3 , p-Cl, p-NO 2 , p-CF 3 , p-OCH 3 , p-CH(CH 3 ) 2 , p-CN or p-COOH.
Claim 12
Dependent Claim
6 words
A compound having the formula ##STR71##
Claim 13
Dependent Claim
6 words
A compound having the formula ##STR71##
Claim 14
Dependent Claim
6 words
A compound having the formula ##STR72##
Claim 15
Dependent Claim
6 words
A compound having the formula ##STR72##
Claim 16
Dependent Claim
6 words
A compound having the formula ##STR73##
Claim 17
Dependent Claim
6 words
A compound having the formula ##STR73##
Claim 18
Dependent Claim
20 words
A pharmaceutical composition comprising a compound as claimed in claim 1 with an effective amount of a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
GB938782A
Cited
US3985723A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-07 | 1982-11-06 | 1983-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-07 | 1986-11-06 | 1987-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-07 | 1990-11-06 | 1991-05-08 | $7700.00 | Window Closed / Lapsed |