US4140864A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted acyl derivatives of amino acids
Assignee: ER Squibb and Sons LLC
•
Filing: 1978-03-24
•
Granted: 1979-02-20
•
Expires: 1998-03-24
Abstract
Abstract New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Miguel A. Ondetti
- 👤 Frank L. Weisenborn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:51
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60; A; A61; A61P; A61P9/00; A61P9/12; C07C; C07C323/00; C07C327/00; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
77 words
A compound of the formula ##STR18## and salts thereof, wherein R 1 is hydroxy or lower alkoxy; R 2 is hydroge, lower alkyl or lower alkanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR19## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is phenyl, phenyl-lower alkylene, or hydroxyphenyl-lower alkylene; X is oxygen or sulfur; m is 0, 1, 2, 3 or 4; and n is 0 or 1.
Claim 2
Dependent Claim
77 words
A compound of the formula ##STR18## and salts thereof, wherein R 1 is hydroxy or lower alkoxy; R 2 is hydroge, lower alkyl or lower alkanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR19## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is phenyl, phenyl-lower alkylene, or hydroxyphenyl-lower alkylene; X is oxygen or sulfur; m is 0, 1, 2, 3 or 4; and n is 0 or 1.
Claim 3
Dependent Claim
17 words
A compound as in claim 1 wherein ##STR20## is the radical of phenyl-alanine, tyrosine, phenylglycine or N-methylphenylalanine.
Claim 4
Dependent Claim
58 words
A compound as in claim 1 wherein R 1 is hydroxy; R 2 is hydrogen, lower alkyl or lower alkanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl or benzoyl; X is oxygen or sulfur; A is hydrogen; B is phenyl-lower alkylene; m is 0 or 1 and n is 0 or 1.
Claim 5
Dependent Claim
11 words
A compound as in claim 1 wherein R 4 is ##STR21##
Claim 6
Dependent Claim
10 words
A compound as in claim 1 wherein X is oxygen.
Claim 7
Dependent Claim
10 words
A compound as in claim 1 wherein X is sulfur.
Claim 8
Dependent Claim
36 words
A compound as in claim 1 wherein R 1 is hydroxy; A, R 2 , R 3 and R 4 each is hydrogen; B is phenylmethyl; X is sulfur; and m and n each is 1.
Claim 9
Dependent Claim
36 words
A compound as in claim 1 wherein R 1 is hydroxy; A, R 2 , R 3 and R 4 each is hydrogen; B is phenylmethyl; X is oxygen; and m and n each is 1.
Claim 10
Dependent Claim
36 words
A compound as in claim 1 wherein R 1 is hydroxy; A, R 2 , R 3 and R 4 each is hydrogen; B is (4-hydroxyphenyl)methyl; X is oxygen; and m and n each is 1.
Claim 11
Dependent Claim
36 words
A compound as in claim 4 wherein each R 1 is hydroxy; each A, R 2 and R 3 is hydrogen; each B is phenylmethyl; each X is oxygen; and each m and n is 1.
Claim 12
Dependent Claim
38 words
A compound as in claim 1 wherein R 1 is hydroxy; R 2 , R 3 and R 4 each is hydrogen; A is methyl; B is phenylmethyl; X is oxygen; and m and n each is 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |