US4134359A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Package of biologically active material stored at a cryogenic temperature at which it is inactive and method of making the same
Assignee: UNITED ANILINE Co
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Filing: 1977-06-27
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Granted: 1979-01-16
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Expires: 1997-06-27
Abstract
Abstract The storage of material that is biologically active such as semen for use in artificial insemination, requires that it be held at a cryogenic temperature at which it is inactive. A package of such a material has a transparent container sealed at one end within which there is a frozen indicator of a color different than that of the material and which has a melting point close to but above a selected cryogenic temperature at which the material is inactive. A barrier is between the material and the indicator and of a type permeable by the indicator if melted and in storage, the indicator containing end of the container is uppermost. The volume of the indicator is such that if the indicator melts, it will flow through the barrier and irreversibly discolor the material as proof that proper storage conditions have not been maintained.
Inventors
- 👤 Donald J. Redpath
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:33
CPC Classifications
A; A61; A61D; A61D19/00; A61D19/02; A61D19/022; A61D19/024; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/146; A01N1/147; G; G01; G01K; G01K11/00; G01K11/06; A61D19/025; Y; Y10; Y10S; Y10S128/00; Y10S128/27
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
213 words
The method of storing for later use semen that is biologically active but becomes inactive at a predetermined cryogenic temperature, said method consisting of the steps of introducing into the closed end of a substantially transparent tube having a closed end a predetermined volume of a liquid indicator that when frozen has a melting point at said predetermined cryogenic temperature and of a color different from that of the semen, placing in said tube a barrier that is permeable by the indicator when thawed, introducing a predetermined volume of semen into the tube, closing the other end of the tube, freezing the contents of the tube with said other end downward at a temperature in the neighborhood of -100° C., and storing the tube with the indicator-containing end of the tube uppermost with a storage temperature such that the indicator and the semen are maintained in their frozen state, the volume of the indicator such that when thawed, the barrier is permeated and the semen immediately discolored as proof that the semen has been exposed to a temperature at which it may have become sub-standard, the tube being readily severable to permit the end of the tube containing the indicator and barrier to be removed if the color of the semen is normal.
Claim 2
Independent Claim
213 words
The method of storing for later use semen that is biologically active but becomes inactive at a predetermined cryogenic temperature, said method consisting of the steps of introducing into the closed end of a substantially transparent tube having a closed end a predetermined volume of a liquid indicator that when frozen has a melting point at said predetermined cryogenic temperature and of a color different from that of the semen, placing in said tube a barrier that is permeable by the indicator when thawed, introducing a predetermined volume of semen into the tube, closing the other end of the tube, freezing the contents of the tube with said other end downward at a temperature in the neighborhood of -100° C., and storing the tube with the indicator-containing end of the tube uppermost with a storage temperature such that the indicator and the semen are maintained in their frozen state, the volume of the indicator such that when thawed, the barrier is permeated and the semen immediately discolored as proof that the semen has been exposed to a temperature at which it may have become sub-standard, the tube being readily severable to permit the end of the tube containing the indicator and barrier to be removed if the color of the semen is normal.
Claim 3
Dependent Claim
22 words
The method of claim 1 in which the indicator is frozen before the barrier is inserted and seated against the frozen indicator.
Claim 4
Dependent Claim
165 words
A package of biologically active semen that becomes inactive at a predetermined cryogenic temperature in the neighborhood of -100° C., said package including a substantially transparent tube having a closed end that is to be the upper end during storage, a frozen predetermined volume of an indicator in said closed end of a color different than that of semen and having a melting point close to but above said predetermined temperature, a frozen, wanted volume of the semen in said tube, a barrier between the indicator and the semen but spaced from the indicator, said barrier permeable by the indicator when and if thawed, and a closure at the other end of the tube, the volume of the indicator such that, if melted it will flow through the barrier and discolor the semen, the tube of a type enabling the end containing the indicator and the barrier to be readily detached if the color of the semen, when it is to be used, is normal.
Claim 5
Dependent Claim
165 words
A package of biologically active semen that becomes inactive at a predetermined cryogenic temperature in the neighborhood of -100° C., said package including a substantially transparent tube having a closed end that is to be the upper end during storage, a frozen predetermined volume of an indicator in said closed end of a color different than that of semen and having a melting point close to but above said predetermined temperature, a frozen, wanted volume of the semen in said tube, a barrier between the indicator and the semen but spaced from the indicator, said barrier permeable by the indicator when and if thawed, and a closure at the other end of the tube, the volume of the indicator such that, if melted it will flow through the barrier and discolor the semen, the tube of a type enabling the end containing the indicator and the barrier to be readily detached if the color of the semen, when it is to be used, is normal.
References Cited (Backward Citations)
US3695903A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-15 | 1982-07-17 | 1983-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-15 | 1986-07-17 | 1987-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-15 | 1990-07-17 | 1991-01-16 | $7700.00 | Window Closed / Lapsed |