US4127667A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted thiopyrano(4,3-b)pyrans
Assignee: ER Squibb and Sons LLC
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Filing: 1978-04-05
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Granted: 1978-11-28
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Expires: 1998-04-05
Abstract
Abstract 3,4,7,8-Tetahydro-2H,5H-thiopyrano[4,3-b]pyrans of the structure ##STR1## are provided wherein X is O, S or SO 2 , R is hydrogen, halogen, lower alkyl, lower alkoxy, cyano or trifluoromethyl, and R' is carbethoxy, carboxy, alkali metal carboxylate and cyano. These compounds are useful as antiinflammatory agents and anti-hypertensive agents.
Inventors
- 👤 George C. Rovnyak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:33
CPC Classifications
C; C07; C07D; C07D495/00; C07D495/02; C07D495/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
39 words
A compound of the structure ##STR6## wherein X is O, S or SO 2 , R is H, halo, alkyl, alkoxy, cyano or trifluoromethyl and R' is carbethoxy, carboxy, alkali metal carboxylate or cyano, and physiologically acceptable salts thereof.
Claim 2
Dependent Claim
39 words
A compound of the structure ##STR6## wherein X is O, S or SO 2 , R is H, halo, alkyl, alkoxy, cyano or trifluoromethyl and R' is carbethoxy, carboxy, alkali metal carboxylate or cyano, and physiologically acceptable salts thereof.
Claim 3
Dependent Claim
9 words
The compound of claim 1 wherein X is S.
Claim 4
Dependent Claim
13 words
The compound of claim 1 wherein X is O or SO 2 .
Claim 5
Dependent Claim
13 words
The compound of claim 1 wherein R is hydrogen, lower alkyl or trifluoromethyl.
Claim 6
Dependent Claim
11 words
The compound of claim 1 wherein R' is carbethoxy or cyano.
Claim 7
Dependent Claim
12 words
The compound of claim 1 having the name 3,4,7,8-tetrahydro-2-oxo-4-phenyl-8-(phenylmethylene)-2H,5H-thiopyrano[4,3-b]pyran-3-carboxylic acid, ethyl ester.
Claim 8
Dependent Claim
12 words
The compound of claim 1 having the name 3,4,7,8-tetrahydro-4-(2-methylphenyl)-8-[(2-methylphenyl)methylene]-2-oxo-2H,5H-thiopyrano[4,3-b]pyran-3-carboxylic acid, ethyl ester.
Claim 9
Dependent Claim
12 words
The compound of claim 1 having the name 3,4,7,8-tetrahydro-2-oxo-4-[3-(trifluoromethyl)phenyl]-8-[[(3-trifluoromethyl)phenyl]methylene]-2H,5H-thiopyrano-[4,3-b]pyran-3-carboxylic acid, ethyl ester.
Claim 10
Dependent Claim
9 words
The compound of claim 1 having the name 3,4,7,8-tetrahydro-2-oxo-4-phenyl-8-(phenylmethylene)-2H,5H-thiopyrano[4,3-b]pyran-3-carbonitrile.
Claim 11
Dependent Claim
17 words
A pharmaceutical composition comprising a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 12
Dependent Claim
24 words
A method for treating an inflammatory condition in mammals, which comprises administering a therapeutically effective amount of a compound as defined in claim 1.
Claim 13
Dependent Claim
22 words
A method for treating hypertension in mammals, which comprises administering a therapeutically effective amount of a compound as defined in claim 1.
References Cited (Backward Citations)
US3979381A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-27 | 1982-05-29 | 1982-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-27 | 1986-05-29 | 1986-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-27 | 1990-05-29 | 1990-11-28 | $7700.00 | Window Closed / Lapsed |