US4116635A
Expired / Lapsed
US
⏱️ 0.0 years remaining
General purpose in vitro anticoagulant
Assignee: Coulter Electronics Inc
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Filing: 1977-03-14
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Granted: 1978-09-26
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Expires: 1997-03-14
Abstract
Abstract A process for testing a blood sample as for coagulation, hematology, chemistries, enzymes, electrolytes and trace metals which involves the addition of a particular anticoagulant. The anticoagulant is a calcium chelating agent having a Log K' of from about 3.4 to 4.2.
Inventors
- 👤 Mark A. Jaeger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:57
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; C; C12; C12Q; C12Q1/00; C12Q1/56
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
64 words
In a process for testing a sample of blood for coagulation, hematology, chemistries, enzymes, electrolytes, and trace metals wherein said sample is introduced into a vessel containing an anticoagulant, the improvement comprising selecting for the anticoagulant a calcium chelating agent having a Log K' from about 3.4 to about 4.2, where Log K' is the logarithm of the conditional stability constant at pH 7.5.
Claim 2
Dependent Claim
64 words
In a process for testing a sample of blood for coagulation, hematology, chemistries, enzymes, electrolytes, and trace metals wherein said sample is introduced into a vessel containing an anticoagulant, the improvement comprising selecting for the anticoagulant a calcium chelating agent having a Log K' from about 3.4 to about 4.2, where Log K' is the logarithm of the conditional stability constant at pH 7.5.
Claim 3
Dependent Claim
35 words
The process of claim 1 wherein the calcium chelating agent is selected from the group consisting of imino deacetic acids, alkaline buffer salts of imino diacetic acids, and alkali metal salts of imino diacetic acids.
Claim 4
Dependent Claim
14 words
The process of claim 2 wherein the calcium chelating agent is N-(2-acetamido)-imino diacetic acid.
Claim 5
Dependent Claim
15 words
The process of claim 2 wherein the calcium chelating agent is hydroxyethyl imino diacetic acid.
Claim 6
Dependent Claim
28 words
The process of claim 2 wherein the calcium chelating agent is an alkaline buffer salt of N-(2-acetamido)-imino diacetic acid selected from the group consisting of Imidazole and Tris.
Claim 7
Dependent Claim
29 words
The process of claim 2 wherein the calcium chelating agent is an alkali metal salt of N-(2-acetamido)-imino diacetic acid selected from the group consisting of potassium, sodium, and lithium.
Claim 8
Dependent Claim
29 words
The process of claim 2 wherein the calcium chelating agent is an alkaline buffer salt of hydroxyethyl imino diacetic acid selected from the group consisting of Imidazole and Tris.
Claim 9
Dependent Claim
30 words
The process of claim 2 wherein the calcium chelating agent is an alkali metal salt of hydroxyethyl imino diacetic acid selected from the group consisting of potassium, sodium, and lithium.
Claim 10
Dependent Claim
22 words
The process of claim 1 wherein about 0.5 to about 2.0 mg of calcium chelating agent per ml of blood is used.
Claim 11
Dependent Claim
22 words
The process of claim 1 wherein about 2.5 to about 10.0 micromoles of calcium chelating agent per ml of blood is used.
References Cited (Backward Citations)
US3859337A
Cited
US3682835A
Cited
US3799885A
Cited
US3852344A
Cited
US3983004A
Cited
US3947378A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-25 | 1982-03-27 | 1982-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-25 | 1986-03-27 | 1986-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-25 | 1990-03-27 | 1990-09-26 | $7700.00 | Window Closed / Lapsed |