US4115540A
Expired / Lapsed
US
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Radiodiagnostic agent
Assignee: University of Kentucky Research Foundation
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Filing: 1976-06-16
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Granted: 1978-09-19
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Expires: 1996-06-16
Abstract
Abstract A radiodiagnostic agent comprising a solid, insoluble nontoxic synthetic resin, such as polystyrene, bearing a detectable amount of technetium 99m thereon. This agent is useful for analyzing the gastrointestinal tract, for example, for gastric emptying time, by means of a gamma camera.
Inventors
- 👤 George A. Digenis
- 👤 Manvendra B. Shambhu
- 👤 Michael C. Theodorakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:00
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1241; A61K2123/00; Y; Y10; Y10S; Y10S436/00; Y10S436/804
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
59 words
A method for analyzing the gastrointestinal tract of a human being or animal which comprises orally administering a diagnostic amount of a solid, insoluble non-toxic synthetic resin bearing a detectable amount of Tc 99m thereon, and analyzing the number of radioactive counts given off by the decay of the Tc 99m as said resin passes through the gastrointestinal tract.
Claim 2
Independent Claim
59 words
A method for analyzing the gastrointestinal tract of a human being or animal which comprises orally administering a diagnostic amount of a solid, insoluble non-toxic synthetic resin bearing a detectable amount of Tc 99m thereon, and analyzing the number of radioactive counts given off by the decay of the Tc 99m as said resin passes through the gastrointestinal tract.
Claim 3
Dependent Claim
37 words
A non-biodegradable radiodiagnostic agent useful for analyzing the gastrointestinal tract which comprises a solid, insoluble, non-toxic synthetic resin bearing a detectable amount of Tc-99m therein, said agent having no appreciable loss of Tc-99m to the digestive system.
Claim 4
Dependent Claim
37 words
A non-biodegradable radiodiagnostic agent useful for analyzing the gastrointestinal tract which comprises a solid, insoluble, non-toxic synthetic resin bearing a detectable amount of Tc-99m therein, said agent having no appreciable loss of Tc-99m to the digestive system.
Claim 5
Dependent Claim
24 words
The non-biodegradable radiodiagnostic agent of claim 2, wherein the synthetic resin is polystyrene containing an aliphatic polyamine to which the Tc-99m is chemically bound.
Claim 6
Dependent Claim
17 words
The non-biodegradable radiodiagnostic agent of claim 2, wherein said aliphatic polyamine is ethylenediamine, diethylenetriamine, triethylenetetramine or pentaethylenetetramine.
Claim 7
Dependent Claim
27 words
The non-biodegradable radiodiagnostic agent of claim 2, wherein the synthetic resin is a polyacrylate containing COOH, OH, or NH 2 functions for chemically bonding the Tc-99m thereto.
Claim 8
Dependent Claim
13 words
The non-biodegradable radiodiagnostic agent of claim 5, wherein the polyacrylate is hydroxymethylmethacrylate polymer.
Claim 9
Dependent Claim
33 words
The non-biodegradable radiodiagnostic agent of claim 2, wherein the synthetic resin is chemically bound to Tc-99 m by a member selected from the group consisting of diethylenetriaminepentacetic acid (DTPA), iminodiacetic acid, and β-diketones.
Claim 10
Dependent Claim
40 words
A process for the preparation of a radiodiagnostic agent which comprises adding phosgene to hydroxymethylmethacrylate polymer followed by the addition of a polyamine and then adding an aqueous solution of sodium pertechnetate thereto, thereby forming a polyamine-Tc-99m complex-containing polyhydroxymethylmethacrylate resin.
Claim 11
Dependent Claim
40 words
A process for the preparation of a radiodiagnostic agent which comprises adding phosgene to hydroxymethylmethacrylate polymer followed by the addition of a polyamine and then adding an aqueous solution of sodium pertechnetate thereto, thereby forming a polyamine-Tc-99m complex-containing polyhydroxymethylmethacrylate resin.
Claim 12
Dependent Claim
63 words
A process for the preparation of a radiodiagnostic agent which comprises mixing chloromethylated polystyrene with an organic swelling agent and then further adding an aliphatic polyamine thereto, heating the mixture until a polyamine-containing resin is obtained, suspending said polyamine-containing resin in an aqueous acidic solution, and then adding an aqueous solution of sodium pertechnetate thereto, thereby forming a polyamine-Tc 99m complex-containing polystyrene resin.
Claim 13
Dependent Claim
63 words
A process for the preparation of a radiodiagnostic agent which comprises mixing chloromethylated polystyrene with an organic swelling agent and then further adding an aliphatic polyamine thereto, heating the mixture until a polyamine-containing resin is obtained, suspending said polyamine-containing resin in an aqueous acidic solution, and then adding an aqueous solution of sodium pertechnetate thereto, thereby forming a polyamine-Tc 99m complex-containing polystyrene resin.
Claim 14
Dependent Claim
15 words
The process of claim 9, wherein said aliphatic polyamine is ethylenediamine, diethylenetriamine, triethylenetetramine or pentaethylenetetramine.
Claim 15
Dependent Claim
12 words
The process of claim 10, wherein said organic swelling agent is pyridine.
References Cited (Backward Citations)
US4010250A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-18 | 1982-03-20 | 1982-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-18 | 1986-03-20 | 1986-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-18 | 1990-03-20 | 1990-09-19 | $7700.00 | Window Closed / Lapsed |