Patent US5372587A successfully refreshed from Google Patents.
US4098571A
Expired / Lapsed
US
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Substitute blood vessel and a process for preparing the same
Assignee: Individual
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Filing: 1976-08-04
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Granted: 1978-07-04
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Expires: 1996-08-04
Abstract
Abstract A process for preparing a heterograft substitute blood vessel comprises digesting a properly pretreated pig blood vessel with a digesting solution containing an animal proteolytic enzyme so as to retain collagenous and elastic fiber constituents substantially in the original state and substantially remove away other tissue constituents of said blood vessel than said two kinds of constituents, and then fixing the resulting digested blood vessel into a desired shape with a liquid fixing agent.
Inventors
- 👤 Kaneyasu Miyata
- 👤 Izumi Amano
- 👤 Takehiko Iwai
- 👤 Tetsuya Asahi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:39
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61L27/36; A61L27/3604; A61L27/3625; A61L27/3641; A61L27/3683; A61L27/3695; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
74 words
A process for preparing a heterograft substitute blood vessel comprising digesting a properly pretreated pig blood vessel with a digesting solution containing an animal proteolytic enzyme so as to retain collagenous and elastic fiber constituents substantially in the original state and substantially remove away other tissue constituents of said blood vessel than said two kinds of constituents, and then fixing the resulting digested blood vessel into a desired shape with a liquid fixing agent.
Claim 2
Dependent Claim
74 words
A process for preparing a heterograft substitute blood vessel comprising digesting a properly pretreated pig blood vessel with a digesting solution containing an animal proteolytic enzyme so as to retain collagenous and elastic fiber constituents substantially in the original state and substantially remove away other tissue constituents of said blood vessel than said two kinds of constituents, and then fixing the resulting digested blood vessel into a desired shape with a liquid fixing agent.
Claim 3
Dependent Claim
27 words
A process as claimed in claim 1, in which said animal proteolytic enzyme is at least one selected from a group consisting of pepsin, trypsin and chymotrypsin.
Claim 4
Dependent Claim
25 words
A process as claimed in claim 1, in which said pig blood vessel is a raw or a protein denaturated blood vessel obtained by freeze-preservation.
Claim 5
Dependent Claim
26 words
A process as claimed in claim 1, in which said liquid fixing agent comprises 5 - 10% formalin solution or 2 - 25% glutaric aldehyde solution.
Claim 6
Dependent Claim
30 words
A process as claimed in claim 1, in which said digesting solution is a mixed buffer solution containing an animal proteolytic enzyme, a thrombus dissolving agent and an anticoagulating agent.
Claim 7
Dependent Claim
29 words
A process as claimed in claim 1, in which said digesting treatment is performed at pH 1.8 - 9.0, at 30° - 40° C. for 2 - 8 hours.
Claim 8
Dependent Claim
41 words
A process as claimed in claim 1, in which said digesting treatment is controlled so that extension percentage of the resulting heterograft substitute blood vessel is more than 40% under 200 g load and its tensile strength more than 1.0 kg.
Claim 9
Dependent Claim
44 words
A process as claimed in claim 1, in which said digesting treatment comprises digesting a raw pig blood vessel with a digesting solution containing about 100 U/ml chymotrypsin at pH 6 - 8 and at 30° - 40° C. for 3 - 8 hours.
Claim 10
Dependent Claim
43 words
A process as claimed in claim 1, in which said digesting treatment comprises digesting a raw pig blood vessel with a digesting solution containing about 1% trypsin at pH 6 - 8 and at 30° - 40° C. for 3 - 8 hours.
Claim 11
Dependent Claim
33 words
A heterograft substitute blood vessel obtained according to the process as claimed in claim 1 and having more than 40% extension percentage under 200 g load and more that 1.0 kg tensile strength.
References Cited (Backward Citations)
US2900644A
Cited
US3927422A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-03 | 1982-01-02 | 1982-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-03 | 1986-01-02 | 1986-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-03 | 1990-01-02 | 1990-07-04 | $7700.00 | Window Closed / Lapsed |