US4070286A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Macroporous microspheroids and a process for their manufacture
Assignee: BIO-TECHNICAL RESOURCES LP
•
Filing: 1976-06-15
•
Granted: 1978-01-24
•
Expires: 1996-06-15
Abstract
Abstract Disclosed herein is a powder of discrete, macroporous, microspheroids, each having an average diameter in the range of 2 to 50 microns and each composed of a plurality of large colloidal particles joined and cemented together at their points of contact by 1 to 10% by weight of nonporous, amorphous silica. These microspheroids have a high degree of mechanical stability and a surface area between about 80 and 110% of that of the large colloidal particles. Also disclosed is a process for the manufacture of this powder.
Inventors
- 👤 Ralph Kingsley Iler
- 👤 Joseph Jack Kirkland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:18
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/282; B01J13/00; B01J13/02; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28014; B01J20/28016; B01J20/28019; B01J20/28026; B01J20/2803; B01J20/28054; B01J20/28057; B01J20/28078; B01J20/28085; C; C04; C04B; C04B14/00; C04B14/005; C04B18/00; C04B18/02; C04B18/027; C09; C09C; C09C1/00; C09C1/28; E; E04; E04C; E04C5/00; E04C5/07; E04C5/073; B01J35/00; B01J35/50; B01J35/51; B01J35/53; C01; C01P; C01P2006/00; C01P2006/16
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
161 words
As an article of manufacture, a powder comprising a plurality of discrete macroporous, microspheroids, each microspheroid having an average diameter in the range of about 2 to about 50 microns and comprising a plurality of contiguous large colloidal particles joined and cemented together at their points of contact by from about 1 to about 10% by weight of non-porous, amorphous silica based on the total weight of the microspheroid, to form a porous matrix, the pores of said microspheroids being uniformly distributed throughout said microspheroid, each of said large colloidal particles having an average diameter in the range of about 0.1 to about 1.0 micron and having a surface of silica and a core of material selected from the group consisting of silica and acid-insoluble refractory metal oxides, said microspheroids having a high degree of mechanical stability and a surface area of between about 80 and about 110% of the total surface area of the large colloidal particles in said microspheroids.
Claim 2
Dependent Claim
161 words
As an article of manufacture, a powder comprising a plurality of discrete macroporous, microspheroids, each microspheroid having an average diameter in the range of about 2 to about 50 microns and comprising a plurality of contiguous large colloidal particles joined and cemented together at their points of contact by from about 1 to about 10% by weight of non-porous, amorphous silica based on the total weight of the microspheroid, to form a porous matrix, the pores of said microspheroids being uniformly distributed throughout said microspheroid, each of said large colloidal particles having an average diameter in the range of about 0.1 to about 1.0 micron and having a surface of silica and a core of material selected from the group consisting of silica and acid-insoluble refractory metal oxides, said microspheroids having a high degree of mechanical stability and a surface area of between about 80 and about 110% of the total surface area of the large colloidal particles in said microspheroids.
Claim 3
Dependent Claim
19 words
The article of claim 1 wherein both the surface and the core of said large colloidal particles are silica.
Claim 4
Dependent Claim
37 words
The article of claim 1 wherein at least about 80% of the porosity of said microspheroids comprises pores having diameters in the range of about 25 to about 150% of the average pore diameter of said microspheroids.
Claim 5
Dependent Claim
25 words
The article of claim 3 wherein less than about 2% of the pores in said microspheroids have an average diameter less than about 0.01 micron.
Claim 6
Dependent Claim
41 words
The article of claim 1 wherein at least about 80% by weight of the microspheroids in said powder have an average diameter in the range of about 50 to about 150% of the average diameter of the microspheroids in said powder.
Claim 7
Dependent Claim
22 words
The article of claim 1 wherein said microspheroids have an average diameter in the range of about 5 to about 20 microns.
Claim 8
Dependent Claim
24 words
The article of claim 6 wherein said large colloidal particles have an average diameter in the range of about 0.2 to about 0.5 micron.
Claim 9
Independent Claim
181 words
An apparatus for use in chromatographic separation comprising a resolving zone through which the material to be separated is passed, said resolving zone being filled with powder comprising a plurality of discrete macroporous, microspheroids, each microspheroid having an average diameter in the range of about 2 to about 50 microns and comprising a plurality of contiguous large colloidal particles joined and cemented together at their points of contact by from about 1 to about 10% by weight of non-porous, amorphous silica based on the total weight of the microspheroid, to form a porous matrix, the pores of said microspheroids being uniformly distributed throughout said microspheroid, each of said large colloidal particles having an average diameter in the range of about 0.1 to about 1.0 micron and having a surface of silica and a core of material selected from the group consisting of silica and acid-insoluble refractory metal oxides, said microspheroids having a high degree of mechanical stability and a surface area of between about 80 and about 110% of the total surface area of the large colloidal particles in said microspheroids.
Claim 10
Independent Claim
181 words
An apparatus for use in chromatographic separation comprising a resolving zone through which the material to be separated is passed, said resolving zone being filled with powder comprising a plurality of discrete macroporous, microspheroids, each microspheroid having an average diameter in the range of about 2 to about 50 microns and comprising a plurality of contiguous large colloidal particles joined and cemented together at their points of contact by from about 1 to about 10% by weight of non-porous, amorphous silica based on the total weight of the microspheroid, to form a porous matrix, the pores of said microspheroids being uniformly distributed throughout said microspheroid, each of said large colloidal particles having an average diameter in the range of about 0.1 to about 1.0 micron and having a surface of silica and a core of material selected from the group consisting of silica and acid-insoluble refractory metal oxides, said microspheroids having a high degree of mechanical stability and a surface area of between about 80 and about 110% of the total surface area of the large colloidal particles in said microspheroids.
Claim 11
Dependent Claim
177 words
A process of chromatographic separation comprising contacting the material to be separated in a carrier phase with a resolving zone filled with powder comprising a plurality of discrete macroporous, microspheroids, each microspheroid having an average diameter in the range of about 2 to about 50 microns and comprising a plurality of contiguous large colloidal particles joined and cemented together at their points of contact by from about 1 to about 10% by weight of non-porous, amorphous silica based on the total weight of the microspheroid, to form a porous matrix, the pores of said microspheroids being uniformly distributed throughout said microspheroid, each of said large colloidal particles having an average diameter in the range of about 0.1 to about 1.0 micron and having a surface of silica and a core of material selected from the group consisting of silica and acid-insoluble refractory metal oxides, said microspheroids having a high degree of mechanical stability and a surface area of between about 80 and about 110% of the total surface area of the large colloidal particles in said microspheroids.
Claim 12
Dependent Claim
177 words
A process of chromatographic separation comprising contacting the material to be separated in a carrier phase with a resolving zone filled with powder comprising a plurality of discrete macroporous, microspheroids, each microspheroid having an average diameter in the range of about 2 to about 50 microns and comprising a plurality of contiguous large colloidal particles joined and cemented together at their points of contact by from about 1 to about 10% by weight of non-porous, amorphous silica based on the total weight of the microspheroid, to form a porous matrix, the pores of said microspheroids being uniformly distributed throughout said microspheroid, each of said large colloidal particles having an average diameter in the range of about 0.1 to about 1.0 micron and having a surface of silica and a core of material selected from the group consisting of silica and acid-insoluble refractory metal oxides, said microspheroids having a high degree of mechanical stability and a surface area of between about 80 and about 110% of the total surface area of the large colloidal particles in said microspheroids.
References Cited (Backward Citations)
US3328230A
Cited
US3505785A
Cited
US3920578A
Cited
US3635824A
Cited
US3782075A
Cited
US3855172A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-23 | 1981-07-25 | 1982-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-23 | 1985-07-25 | 1986-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-23 | 1989-07-25 | 1990-01-24 | $7700.00 | Window Closed / Lapsed |