Patent US2242692A successfully refreshed from Google Patents.
US4061741A
Expired / Lapsed
US
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Physiological substances for intensifying the pharmacological effect of drugs
Assignee: Servomed Arzneimittel GmbH
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Filing: 1975-03-27
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Granted: 1977-12-06
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Expires: 1995-03-27
Abstract
Abstract Composition comprising a medicament and orotic acid and/or physiologically compatible salt thereof, and/or uridin-5-monophosphate in an amount sufficient to increase the efficiency of the composition, methods of use and preparation of the compositions are provided.
Inventors
- 👤 Wolfgang Wawretschek
- 👤 Lothar Wawretschek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:39
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/66; A61K31/675; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K2123/00
Claims Analysis
Total Claims: 44
Claim 1
Independent Claim
174 words
A method of treating a patient suffering from pain which comprises enterally or parenterally administering to said patient an enterally or parenterally administrable central nervous system effective analgesic composition selected from the group consisting of: (a) a composition comprising a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins, and a member selected from the group consisting of orotic acid (1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid), physiologically compatible orotic acid salts other than with said central nervous system analgesic, and mixtures thereof in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic; (b) composition comprising a physiologically compatible orotic acid salt of a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins wherein the orotic acid moiety is in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic, and mixtures of (a) and (b).
Claim 2
Independent Claim
174 words
A method of treating a patient suffering from pain which comprises enterally or parenterally administering to said patient an enterally or parenterally administrable central nervous system effective analgesic composition selected from the group consisting of: (a) a composition comprising a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins, and a member selected from the group consisting of orotic acid (1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid), physiologically compatible orotic acid salts other than with said central nervous system analgesic, and mixtures thereof in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic; (b) composition comprising a physiologically compatible orotic acid salt of a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins wherein the orotic acid moiety is in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic, and mixtures of (a) and (b).
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said member is orotic acid.
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein said member is an orotic acid salt.
Claim 5
Dependent Claim
19 words
The method of claim 1 wherein the molar ratio of said member to said analgesic is at least 1:1.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein the molar ratio of said member to said analgesic is 2:1.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein said member is choline orotate.
Claim 8
Dependent Claim
17 words
The method of claim 1 which comprises administering a physiologically compatible orotic acid salt of said analgesic.
Claim 9
Dependent Claim
14 words
The method of claim 7 wherein said salt is orotic acid salt of dextropropoxyphene.
Claim 10
Dependent Claim
13 words
The method of claim 7 wherein said salt is a salt of codeine.
Claim 11
Dependent Claim
11 words
The method of claim 1 wherein said analgesic is sodium salicylate.
Claim 12
Dependent Claim
10 words
The method of claim 1 wherein said analgesic is metamizol.
Claim 13
Dependent Claim
10 words
The method of claim 1 wherein said analgesic is codeine.
Claim 14
Dependent Claim
25 words
The method of claim 7 which comprises administering a mixture of the orotic acid salt of the analgesic and another physiologically compatible orotic acid salt.
Claim 15
Dependent Claim
12 words
The method of claim 1 which comprises administering orotic acid and metamizol.
Claim 16
Dependent Claim
11 words
The method of claim 14 which contains orotic acid and metamizol.
Claim 17
Dependent Claim
156 words
An enterally or parenterally administrable central nervous system effective analgesic composition selected from the group consisting of: (a) a composition comprising a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins, and a member selected from the group consisting of orotic acid (1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid), physiologically compatible orotic acid salts other than with said central nervous system analgesic and mixtures thereof in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic; (b) composition comprising a physiologically compatible orotic acid salt of a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins wherein the orotic acid moiety is in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic, and mixtures of (a) and (b).
Claim 18
Dependent Claim
156 words
An enterally or parenterally administrable central nervous system effective analgesic composition selected from the group consisting of: (a) a composition comprising a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins, and a member selected from the group consisting of orotic acid (1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid), physiologically compatible orotic acid salts other than with said central nervous system analgesic and mixtures thereof in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic; (b) composition comprising a physiologically compatible orotic acid salt of a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins wherein the orotic acid moiety is in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic, and mixtures of (a) and (b).
Claim 19
Dependent Claim
11 words
The composition of claim 16 wherein said member is orotic acid.
Claim 20
Dependent Claim
13 words
The composition of claim 16 wherein said member is an orotic acid salt.
Claim 21
Dependent Claim
23 words
The composition of claim 16 wherein said analgesic is selected from the group consisting of sodium salicylate, codeine, metamizol, dextropropoxyphene, and mixtures thereof.
Claim 22
Dependent Claim
19 words
The composition of claim 16 wherein the molar ratio of said member to said analgesic is at least 1:1.
Claim 23
Dependent Claim
17 words
The composition of claim 16 wherein the molar ratio of said member to said analgesic is 2:1.
Claim 24
Dependent Claim
11 words
The composition of claim 16 wherein said member is choline orotate.
Claim 25
Dependent Claim
16 words
The composition of claim 16 which comprises a physiologically compatible orotic acid salt of said analgesic.
Claim 26
Dependent Claim
14 words
The composition of claim 23 wherein said salt is orotic acid salt of dextropropoxyphene.
Claim 27
Dependent Claim
13 words
The composition of claim 23 wherein said salt is a salt of codeine.
Claim 28
Dependent Claim
11 words
The composition of claim 16 wherein said analgesic is sodium salicylate.
Claim 29
Dependent Claim
10 words
The composition of claim 16 wherein said analgesic is metamizol.
Claim 30
Dependent Claim
10 words
The composition of claim 16 wherein said analgesic is codeine.
Claim 31
Dependent Claim
24 words
The composition of claim 16 which includes a mixture of the orotic acid salt of the analgesic and another physiologically compatible orotic acid salt.
Claim 32
Dependent Claim
12 words
The composition of claim 16 which contains orotic acid and sodium salicylate.
Claim 33
Dependent Claim
11 words
The composition of claim 16 which contains orotic acid and metamizol.
Claim 34
Independent Claim
169 words
A method for increasing the analgesic efficiency of an enterally or parenterally administrable central nervous system effective analgesic composition selected from the group consisting of: (a) a composition containing a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins which comprises adding to said analgesic a member selected from the group consisting of orotic acid (1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid), physiologically compatible orotic acid salts other than with said central nervous system analgesic, and mixtures thereof in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic; (b) composition comprising a physiologically compatible orotic acid salt of a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins wherein the orotic acid moiety is in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic, and mixtures of (a) and (b).
Claim 35
Independent Claim
169 words
A method for increasing the analgesic efficiency of an enterally or parenterally administrable central nervous system effective analgesic composition selected from the group consisting of: (a) a composition containing a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins which comprises adding to said analgesic a member selected from the group consisting of orotic acid (1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid), physiologically compatible orotic acid salts other than with said central nervous system analgesic, and mixtures thereof in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic; (b) composition comprising a physiologically compatible orotic acid salt of a central nervous system analgesic which exhibits in vivo and in vitro an affinity for blood proteins wherein the orotic acid moiety is in an amount sufficient to increase the amount of said analgesic which is ultrafilterable from serum and to increase the analgesic efficiency of said analgesic, and mixtures of (a) and (b).
Claim 36
Dependent Claim
11 words
The method of claim 32 wherein said member is orotic acid.
Claim 37
Dependent Claim
13 words
The method of claim 32 wherein said member is an orotic acid salt.
Claim 38
Dependent Claim
23 words
The method of claim 32 wherein said analgesic is selected from the group consisting of sodium, salicylate, codeine, metamizol, dextropropoxyphene, and mixtures thereof.
Claim 39
Dependent Claim
19 words
The method of claim 32 wherein the molar ratio of said member to said analgesic is at least 1:1.
Claim 40
Dependent Claim
17 words
The method of claim 32 wherein the molar ratio of said member to said analgesic is 2:1.
Claim 41
Dependent Claim
11 words
The method of claim 32 wherein said member is choline orotate.
Claim 42
Dependent Claim
11 words
The method of claim 32 wherein said analgesic is sodium salicylate.
Claim 43
Dependent Claim
10 words
The method of claim 32 wherein said analgesic is metamizol.
Claim 44
Dependent Claim
10 words
The method of claim 32 wherein said analgesic is codeine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-05 | 1981-06-06 | 1981-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-05 | 1985-06-06 | 1985-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-05 | 1989-06-06 | 1989-12-06 | $7700.00 | Window Closed / Lapsed |