US4056496A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydrogels and articles made therefrom
Assignee: Corneal Sciences Inc
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Filing: 1976-05-13
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Granted: 1977-11-01
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Expires: 1996-05-13
Abstract
Abstract This invention relates to polymers and hydrogels of polymers formed from a hydrophilic monomer of the group of dihydroxyalkyl acrylates and methacrylates, a substantially water insoluble monomer from the group of alkyl acrylates and methacrylates and preferably a minor amount of a water insoluble epoxidized alkyl acrylate or methacrylate. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices: dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry, and the like.
Inventors
- 👤 William L. Mancini
- 👤 Donald R. Korb
- 👤 Miguel F. Refojo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:23
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K6/00; A61K6/80; A61K6/884; A61K6/887; C; C08; C08F; C08F220/00; C08F220/02; C08F220/10; C08F220/26; C08F220/28; C08F220/282; G; G02; G02B; G02B1/00; G02B1/04; G02B1/041; G02B1/043; Y; Y10; Y10S; Y10S521/00; Y10S521/905; Y10S524/00; Y10S524/916; Y10S528/00; Y10S528/92
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
139 words
A polymer formed by a free radical, bulk polymerization of a first hydrophilic monomer conforming to the formula: ##STR4## where R is hydrogen or methyl or methyl and n is a whole integer having a value of from 0 to 4, a second substantially water insoluble monomer conforming to the formula: ##STR5## where R is as above described and R' is alkyl having from 1 to 6 carbon atoms, the mole ratio of said first monomer to said second monomer varying between 1:3 and 20:1, and a third substantially water insoluble monomer conforming to the formula ##STR6## where R and n are as above defined, the concentration of said third monomer varying between 0 and 30% by weight of the first monomer, said polymer being insoluble in a member selected from the group of acetone, dioxane and mixtures thereof.
Claim 2
Dependent Claim
139 words
A polymer formed by a free radical, bulk polymerization of a first hydrophilic monomer conforming to the formula: ##STR4## where R is hydrogen or methyl or methyl and n is a whole integer having a value of from 0 to 4, a second substantially water insoluble monomer conforming to the formula: ##STR5## where R is as above described and R' is alkyl having from 1 to 6 carbon atoms, the mole ratio of said first monomer to said second monomer varying between 1:3 and 20:1, and a third substantially water insoluble monomer conforming to the formula ##STR6## where R and n are as above defined, the concentration of said third monomer varying between 0 and 30% by weight of the first monomer, said polymer being insoluble in a member selected from the group of acetone, dioxane and mixtures thereof.
Claim 3
Dependent Claim
22 words
The polymer of claim 1 where the mole ratio of the first monomer to the second monomer varies between 1:1 and 10:1.
Claim 4
Dependent Claim
14 words
The polymer of claim 2 where the mole ratio varies between 1.2:1 and 2:1.
Claim 5
Dependent Claim
19 words
The polymer of claim 1 where the first monomer is 2,3-dihydroxypropyl methacrylate and the second monomer is methyl methacrylate.
Claim 6
Dependent Claim
23 words
The polymer of claim 1 where the concentration of the third monomer is at least 0.1 percent by weight of the first monomer.
Claim 7
Dependent Claim
22 words
The polymer of claim 5 where the mole ratio of the first monomer to the second monomer varies between 1:1 and 10:1.
Claim 8
Dependent Claim
13 words
The polymer of claim 6 where the ratio varies between 1.2:1 and 2:1.
Claim 9
Dependent Claim
17 words
The polymer of claim 5 where the concentration of the third monomer varies between 0.1 and 30%.
Claim 10
Dependent Claim
13 words
The polymer of claim 8 where the concentration varies between 1 and 15%.
Claim 11
Dependent Claim
13 words
The polymer of claim 8 where the concentration varies between 3 and 7%.
Claim 12
Dependent Claim
59 words
The polymer of claim 5 where the first monomer is 2,3-dihydroxypropyl methacrylate, the second monomer is methyl methacrylate, the ratio of said first monomer to said second monomer varying between 1:1 and 10:1, and the concentration of said third monomer is sufficient to yield a hydrogel with water having a percent hydration of from 35 to 50% by weight.
Claim 13
Dependent Claim
12 words
The polymer of claim 11 where the third monomer is glycidyl methacrylate.
Claim 14
Dependent Claim
37 words
The polymer of claim 12 having been formed from said monomeric mixture also including a difunctional acrylate or methacrylate as a crosslinking agent in an amount not exceeding 5% by weight of the total of the monomers.
Claim 15
Dependent Claim
29 words
The polymer of claim 13 where the concentration of said crosslinking agent is sufficient to yield a hydrogel with water having a percent hydration of from 42 to 46%.
Claim 16
Dependent Claim
9 words
A shaped article from the polymer of claim 1.
Claim 17
Dependent Claim
9 words
The shaped article of claim 15 hydrated with water.
Claim 18
Dependent Claim
9 words
A shaped article from the polymer of claim 5.
Claim 19
Dependent Claim
9 words
The shaped article of claim 17 hydrated with water.
Claim 20
Dependent Claim
13 words
The shaped article of claim 18 in the form of a contact lens.
Claim 21
Dependent Claim
9 words
A shaped article from the polymer of claim 7.
Claim 22
Dependent Claim
9 words
The shaped article of claim 20 hydrated with water.
Claim 23
Dependent Claim
13 words
The shaped article of claim 21 in the form of a contact lens.
Claim 24
Dependent Claim
9 words
A shaped article from the polymer of claim 11.
Claim 25
Dependent Claim
9 words
The shaped article of claim 23 hydrated with water.
Claim 26
Dependent Claim
13 words
The shaped article of claim 30 in the form of a contact lens.
Claim 27
Dependent Claim
9 words
A shaped article from the polymer of claim 13.
Claim 28
Dependent Claim
9 words
The shaped article of claim 26 hydrated with water.
Claim 29
Dependent Claim
13 words
The shaped article of claim 27 in the form of a contact lens.
Claim 30
Dependent Claim
15 words
The polymer of claim 13 where the difunctional acrylate or methacrylate is ethylene glycol dimethacrylate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-31 | 1981-05-02 | 1981-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-31 | 1985-05-02 | 1985-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-31 | 1989-05-02 | 1989-11-01 | $7700.00 | Window Closed / Lapsed |