US4056468A
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Isolation of component materials of aqueous solutions soluble in lipophilic solvents
Assignee: Merck Patent GmbH
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Filing: 1975-02-25
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Granted: 1977-11-01
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Expires: 1995-02-25
Abstract
Abstract Process for the isolation of component materials of aqueous solutions by adsorption of the aqueous solutions on concentration agents based on silica gel and/or kieselguhr and subsequent extraction of the component materials with lipophilic solvents, which employs as concentration agents flowable silica gels and/or kieselguhrs with an average particle size of 0.05 to 1.0 mm., an average pore volume of 0.2 to 3 ml./g., and a specific surface of 0.2 to 50 m 2 /g.
Inventors
- 👤 Joachim Breiter
- 👤 Roland Helger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:52
CPC Classifications
G; G01; G01N; G01N1/00; G01N1/28; G01N1/40; G01N1/405; B; B01; B01J; B01J20/00; B01J20/02; B01J20/10; B01J20/103; B01J20/14; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28054; B01J20/28057; B01J20/28059; B01J20/28069; B01J20/281; B01J20/282; B01J20/283; B01J20/291; B01J20/30; B01J20/3092; G01N25/00; G01N25/14; G01N30/00; G01N33/00; G01N33/18; G01N33/1826; G01N33/48; G01N33/50; G01N33/94; B01J2220/00; B01J2220/40; B01J2220/42; B01J2220/50; B01J2220/54; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104165; Y10T436/107497; Y10T436/108331; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
153 words
In a process for the isolation of lipophilic solvent-soluble components from an aqueous solution containing lipophilic components comprising contacting the aqueous solution with one or both of a silica gel-based or kieselguhr-based concentration agent to absorb said aqueous solution therein and subsequently extracting substantially only the lipophilic solvent-soluble components from the aqueous solution absorbed in the concentration agent with a lipophilic solvent, the improvement which comprises employing as the concentration agent a flowable silica gel of kieselguhr or a mixture thereof, having an average particle size of 0.05 to 1.0 mm., an average pore volume of 0.2 to 3 ml./g. and a specific surface to 0.2 to 50 m 2 /g., and said extracting is conducted without substantial simultaneous desorption of the water of said absorbed aqueous solution, said lipophilic solvent-soluble components being at least one analgesic, sedative, hypnotic, anti-epileptic, psychopharmaceutical, sympathicomimetic, anti-histamine, narcotic, alkaloid, antibiotic, lipid, triglyceride, fatty acid, steroid or porphyrin.
Claim 2
Dependent Claim
153 words
In a process for the isolation of lipophilic solvent-soluble components from an aqueous solution containing lipophilic components comprising contacting the aqueous solution with one or both of a silica gel-based or kieselguhr-based concentration agent to absorb said aqueous solution therein and subsequently extracting substantially only the lipophilic solvent-soluble components from the aqueous solution absorbed in the concentration agent with a lipophilic solvent, the improvement which comprises employing as the concentration agent a flowable silica gel of kieselguhr or a mixture thereof, having an average particle size of 0.05 to 1.0 mm., an average pore volume of 0.2 to 3 ml./g. and a specific surface to 0.2 to 50 m 2 /g., and said extracting is conducted without substantial simultaneous desorption of the water of said absorbed aqueous solution, said lipophilic solvent-soluble components being at least one analgesic, sedative, hypnotic, anti-epileptic, psychopharmaceutical, sympathicomimetic, anti-histamine, narcotic, alkaloid, antibiotic, lipid, triglyceride, fatty acid, steroid or porphyrin.
Claim 3
Dependent Claim
44 words
A process according to claim 1, wherein the concentration agent is a silica gel with an average particle size of 0.15 to 0.4 mm., an average pore volume of 0.5 to 1.7 ml./g. and a specific surface of 0.3 to 20 m 2 /g.
Claim 4
Dependent Claim
22 words
A process according to claim 2 wherein the specific surface of the silica gel is not more than 0.8 m 2 /g.
Claim 5
Dependent Claim
33 words
A process according to claim 2 wherein said silica gel has a specific surface of 0.8 m 2 /g., an average pore diameter of 40,000 angstroms and a pore volume of 0.7 ml./g.
Claim 6
Dependent Claim
43 words
A process according to claim 1, wherein the concentration agent is a kieselguhr with an average particle size of 0.15 to 0.4 mm., an average pore volume of 0.5 to 1.7 ml./g. and a specific surface of 0.5 to 5 m 2 /g.
Claim 7
Dependent Claim
14 words
A process according to claim 1, wherein the aqueous solution is a body fluid.
Claim 8
Dependent Claim
15 words
A process according to claim 6, wherein the body fluid is a sample of urine.
Claim 9
Dependent Claim
31 words
A process according to claim 1, wherein the weight ratio of aqueous solution to concentration agent is from 1:0.4 to 1:1.25 for kieselguhr and from 1:0.9 to 1:1.7 for silica gel.
Claim 10
Dependent Claim
30 words
A process according to claim 1, wherein the solvent is a water immiscible organic solvent or mixtures thereof or is a mixture of water immiscible and water miscible organic solvents.
Claim 11
Dependent Claim
22 words
A process according to claim 9, wherein the water immiscible solvent is a chlorinated alkane and the water miscible solvent is isopropanol.
Claim 12
Dependent Claim
52 words
A process according to claim 1, wherein a measured amount of the concentration agent is packaged in a single-use container adapted to store the concentration agent with the aqueous solution adsorbed thereon prior to extraction of the lipophilic-soluble components from the aqueous solution absorbed in the concentration agent with a lipophilic solvent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1980-10-31 | 1981-05-02 | 1981-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-31 | 1985-05-02 | 1985-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-31 | 1989-05-02 | 1989-11-01 | $7700.00 | Window Closed / Lapsed |