US4044125A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of stabilizing acetylsalicylic acid in the presence of d-propoxyphene hydrochloride and compositions thereof
Assignee: Eli Lilly and Co
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Filing: 1976-03-22
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Granted: 1977-08-23
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Expires: 1996-03-22
Abstract
Abstract Method of inhibiting the hydrolysis of acetylsalicyclic acid in the presence of d-propoxyphene hydrochloride in pharmaceutical compositions comprising admixing the hydrochloride of one of the 23 naturally occuring amino acids therewith, and compositions containing such amino acid hydrochloride, acetylsalicylic acid and d-propoxyphene hydrochloride.
Inventors
- 👤 Walter D. Walkling
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:45
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/60; A61K31/618; A61K31/621; A61K47/00; A61K47/06; A61K47/16; A61K47/18; A61K47/183
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
49 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising actylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating glutamic acid hydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 2
Independent Claim
49 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising actylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating glutamic acid hydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 3
Independent Claim
48 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising acetylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating lysine dihydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 4
Independent Claim
48 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising acetylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating lysine dihydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 5
Independent Claim
48 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising acetylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating glycine hydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 6
Independent Claim
48 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising acetylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating glycine hydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 7
Independent Claim
48 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising acetylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating alanine hydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 8
Independent Claim
48 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising acetylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating alanine hydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 9
Independent Claim
49 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising acetylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating aspartic acid hydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
Claim 10
Independent Claim
49 words
The method of inhibiting the hydrolysis of acetylsalicylic acid in a pharmaceutical composition comprising acetylsalicylic acid and d-propoxyphene hydrochloride which comprises incorporating aspartic acid hydrochloride into such pharmaceutical composition in an amount of from about 5 to about 130 percent by weight of d-propoxyphene hydrochloride in such pharmaceutical composition.
References Cited (Backward Citations)
US2101867A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-22 | 1981-02-21 | 1981-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-22 | 1985-02-21 | 1985-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-22 | 1989-02-21 | 1989-08-23 | $7700.00 | Window Closed / Lapsed |