US4036945A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and method for determining the size and location of myocardial infarcts
Assignee: General Hospital Corp
•
Filing: 1976-05-03
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Granted: 1977-07-19
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Expires: 1996-05-03
Abstract
Abstract Radioactive labelled antibody for cardiac myosin is injected intravenously after cardiac occlusion and is specifically absorbed in infarcted myocardium, as are radioactive labelled lower molecular weight fragments of the antibody such as (Fab') 2 , (Fab'), and (Fv). The location and size of the myocardial infarct can be determined by measuring the intensity and location of radioactive emission externally of the heart.
Inventors
- 👤 Edgar Haber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:47
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1018; A61K2123/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
32 words
A composition comprising a physiologically acceptable injection vehicle and a member of the group consisting of radioactive labelled antibody for cardiac myosin and radioactive labelled lower molecular weight fragments of said antibody.
Claim 2
Dependent Claim
32 words
A composition comprising a physiologically acceptable injection vehicle and a member of the group consisting of radioactive labelled antibody for cardiac myosin and radioactive labelled lower molecular weight fragments of said antibody.
Claim 3
Dependent Claim
26 words
A composition as claimed in claim 1 in which said fragments are selected from the group consisting of (Fab') 2 , (Fab') 1 , and (Fv).
Claim 4
Dependent Claim
21 words
A composition as claimed in claim 1 in which said member is radioactive labeled lower molecular weight fragment (Fab') 2 .
Claim 5
Dependent Claim
50 words
The method of determining the location and size of myocardial infarction which comprises injecting intravenously after coronary occlusion an amount of the composition claimed in claim 1 to provide radioactive emissions detectable externally of the body, then measuring the intensity and location of radioactive emissions with reference to the heart.
Claim 6
Dependent Claim
50 words
The method of determining the location and size of myocardial infarction which comprises injecting intravenously after coronary occlusion an amount of the composition claimed in claim 2 to provide radioactive emissions detectable externally of the body, then measuring the intensity and location of radioactive emissions with reference to the heart.
Claim 7
Dependent Claim
50 words
The method of determining the location and size of myocardial infarction which comprises injecting intravenously after coronary occlusion an amount of the composition claimed in claim 3 to provide radioactive emissions detectable externally of the body, then measuring the intensity and location of radioactive emissions with reference to the heart.
References Cited (Backward Citations)
US3812245A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-18 | 1981-01-17 | 1981-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-18 | 1985-01-17 | 1985-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-18 | 1989-01-17 | 1989-07-19 | $7700.00 | Window Closed / Lapsed |