US4035483A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antiseptic and non-toxic substance and a method of making the same
Assignee: Individual
•
Filing: 1975-08-06
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Granted: 1977-07-12
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Expires: 1995-08-06
Abstract
Abstract A non-toxic, antimicrobial, surgically effective antiseptic material comprising the reaction product of hypochlorite and a protein is described. It is useful in treating burns and other wounds to prevent, control, and treat infection without interfering with the normal healing process. A preferred embodiment is a biological dressing comprising the antiseptic material in a film of a biologically acceptable organic substance.
Inventors
- 👤 John Bunyan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:02
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L26/00; A61L26/0009; A61L26/0028
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
42 words
A surgically active antiseptic composition, effective in controlling or preventing infection in wounds, and comprising a surgically active antiseptic concentration of the reaction product obtained by mixing together a protein and a substantially stoichiometric amount of an aqueous solution of a hypochlorite.
Claim 2
Dependent Claim
42 words
A surgically active antiseptic composition, effective in controlling or preventing infection in wounds, and comprising a surgically active antiseptic concentration of the reaction product obtained by mixing together a protein and a substantially stoichiometric amount of an aqueous solution of a hypochlorite.
Claim 3
Dependent Claim
19 words
A composition according to claim 1 in the form of a powder consisting essentially of the said reaction product.
Claim 4
Dependent Claim
16 words
A composition according to claim 1 comprising the said reaction product and a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
15 words
A composition according to claim 1 comprising an aqueous solution of the said reaction product.
Claim 6
Dependent Claim
24 words
A composition according to claim 1 in the form of a dressing comprising the reaction product impregnated in or coated on a sheet carrier.
Claim 7
Dependent Claim
17 words
A composition according to claim 1 in which the hypochlorite is selected from sodium or lithium hypochlorites.
Claim 8
Dependent Claim
29 words
A composition according to claim 1 in which the hypochlorite is selected from sodium or lithium hypochlorite aqueous solutions having a concentration substantially of 5.25% measured as active chlorine.
Claim 9
Dependent Claim
17 words
A composition according to claim 1 in which the protein is selected from animal or vegetable proteins.
Claim 10
Dependent Claim
19 words
A composition according to claim 1 in which the protein is selected from animal tissue, blood sera or gelatin.
Claim 11
Dependent Claim
12 words
A composition according to claim 1 in which the protein is gelatin.
Claim 12
Independent Claim
46 words
A method of preventing or controlling infection in an external wound comprising treating the wound with a composition comprising a surgically active antiseptic concentration of the reaction product obtained by mixing together a protein and a substantially stoichiometric amount of an aqueous solution of a hypochlorite.
Claim 13
Independent Claim
46 words
A method of preventing or controlling infection in an external wound comprising treating the wound with a composition comprising a surgically active antiseptic concentration of the reaction product obtained by mixing together a protein and a substantially stoichiometric amount of an aqueous solution of a hypochlorite.
Claim 14
Dependent Claim
25 words
A method according to claim 11 comprising treating the wound with an aqueous solution comprising a surgically active antiseptic concentration of the said reaction product.
Claim 15
Dependent Claim
38 words
A method according to claim 11 comprising applying over the wound a sheet carrier that has on the surface in contact with the wound, or is impregnated with, a surgically active antiseptic concentration of the said reaction product.
Claim 16
Dependent Claim
45 words
A biological dressing that is a surgically effective antiseptic and that comprises a film of a biologically acceptable film-forming substance and a surgically active antiseptic concentration of the reaction product of an aqueous solution of hypochlorite with at least a substantially stoichiometric amount of protein.
Claim 17
Dependent Claim
45 words
A biological dressing that is a surgically effective antiseptic and that comprises a film of a biologically acceptable film-forming substance and a surgically active antiseptic concentration of the reaction product of an aqueous solution of hypochlorite with at least a substantially stoichiometric amount of protein.
Claim 18
Dependent Claim
17 words
A dressing according to claim 14 in which the biologically acceptable film-forming substance is a proteinaceous material.
Claim 19
Dependent Claim
23 words
A dressing according to claim 14 in which the biologically acceptable film-forming substance is selected from fibrin, collagen, gelatin, alginate or animal skin.
Claim 20
Dependent Claim
20 words
A dressing according to claim 14 in which the protein with which the hypochlorite is reacted is a film-forming protein.
Claim 21
Dependent Claim
24 words
A dressing according to claim 14 in which the film-forming substance and the protein with which the hypochlorite is reacted are the same protein.
Claim 22
Dependent Claim
25 words
A dressing according to claim 14 made by reacting hypochlorite with from 2 to 10 times by weight the stoichiometric amount of a film-forming protein.
Claim 23
Dependent Claim
42 words
A dressing according to claim 14 made by combining a surgically active antiseptic concentration of a reaction product made by mixing together a protein and a substantially stoichiometric amount of an aqueous solution of a hypochlorite with the biologically acceptable film-forming substance.
Claim 24
Dependent Claim
30 words
A dressing according to claim 14 in which the weight of biologically acceptable film-forming substance is from 1 to 10 times the weight of protein that has reacted with hypochlorite.
Claim 25
Dependent Claim
12 words
A dressing according to claim 14 in which the protein is gelatin.
Claim 26
Dependent Claim
13 words
A dressing according to claim 14 in which the film-forming substance is gelatin.
Claim 27
Dependent Claim
14 words
A dressing according to claim 14 in which the film includes a fibrous reinforcement.
Claim 28
Dependent Claim
14 words
A dressing according to claim 14 including also a fibrous backing for the film.
Claim 29
Independent Claim
50 words
A method of making a surgically active antiseptic comprising reacting substantially stoichiometric amounts of a protein and an aqueous solution of a hypochlorite, the amount of hypochlorite in the reaction mixture being above 0.5 percent measured as active chlorine, to obtain a reaction product having a surgically active antiseptic concentration.
Claim 30
Independent Claim
50 words
A method of making a surgically active antiseptic comprising reacting substantially stoichiometric amounts of a protein and an aqueous solution of a hypochlorite, the amount of hypochlorite in the reaction mixture being above 0.5 percent measured as active chlorine, to obtain a reaction product having a surgically active antiseptic concentration.
Claim 31
Dependent Claim
13 words
A method according to claim 26 conducted at a temperature below 80° F.
Claim 32
Dependent Claim
24 words
A method according to claim 26 in which the protein is gelatin, and the hypochlorite solution is a solution of sodium or lithium hypochlorite.
Claim 33
Dependent Claim
22 words
A method according to claim 26 with the additional step of incorporating the product with a sheet carrier to form a dressing.
Claim 34
Independent Claim
73 words
A method of making a biological dressing comprising reacting a hypochlorite solution of greater than 0.5% concentration with at least twice the stoichiometric amount of a proteinaceous film-forming material or combining a reaction product made by reacting substantially stoichiometric amounts of a protein and an aqueous solution of hypochlorite in a solution greater than 0.5% and combining the reaction product, in a surgically active antiseptic concentration, with a film-forming biologically acceptable organic substance.
Claim 35
Independent Claim
73 words
A method of making a biological dressing comprising reacting a hypochlorite solution of greater than 0.5% concentration with at least twice the stoichiometric amount of a proteinaceous film-forming material or combining a reaction product made by reacting substantially stoichiometric amounts of a protein and an aqueous solution of hypochlorite in a solution greater than 0.5% and combining the reaction product, in a surgically active antiseptic concentration, with a film-forming biologically acceptable organic substance.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-11 | 1981-01-10 | 1981-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-11 | 1985-01-10 | 1985-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-11 | 1989-01-10 | 1989-07-12 | $7700.00 | Window Closed / Lapsed |