← Back to Patent Explorer
US4034601A Expired / Lapsed US ⏱️ 0.0 years remaining

Method and apparatus for determining coagulation times

Assignee: Baxter Healthcare Corp
•
Filing: 1976-04-12
•
Granted: 1977-07-12
•
Expires: 1996-04-12
📄 Original PDF 🌐 Google Patents 🔄 Sync Now

Abstract

Abstract A method and apparatus for determining coagulation times in such clinical laboratory procedures as prothrombin times tests, activated partial thromboplastin time tests, fibrinogen determinations, factor assays for specific blood coagulation factors, and the like. A fibrous filament is drawn at a predetermined rate through a small body of liquid to be tested and the interval, from the time a suitable coagulating agent is mixed with the liquid to the time the body of liquid clings to the filament and moves with it, is precisely measured as a direct indication of actual coagulation time. The liquid body is supported upon a non-wettable inclined surface bordered by walls defining a well for receiving the liquid and a pathway for its movement. Particularly effective results are achieved by utilizing a pair of spaced filaments moving at precisely the same rate, the filaments being bridged by a web or mass of clotted liquid when coagulation occurs. A photodetector senses movement of the clot and a timer automatically measures the time between coagulant addition and clot formation. After clot detection occurs, an arm lifts the paired filaments from the well while at the same time directing the advancing filaments through slots to strip coagulum therefrom, then lifts the filaments out of the slots to permit fresh filament sections to move into place, and finally lowers the fresh sections onto a clean inclined surface for another coagulation test. Means are also disclosed for gently agitating the coagulating agent or agents prior to admixture with the test liquid, for insuring proper suspension of the reactants, and for reducing risks of infection and cross contamination during use of the apparatus.

Inventors

  • 👤 Mario Theodore Geiger

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 13:39
CPC Classifications
G; G04; G04F; G04F8/00; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4905

Claims Analysis

Total Claims: 17
Claim 1
Independent Claim 90 words
A method for determining the coagulation time for a body of fluid, supported on a non-wettable surface, following the intermixing of a coagulation agent with said fluid, comprising the steps of drawing a filament through said fluid body at a predetermined rate, and detecting when said body clings to said filament and commences to move therewith along and upon said surface, the interval between intermixing of said fluid and agent and the commencement of movement of said body bearing a direct relation to the actual coagulation time of said fluid.
Claim 2
Independent Claim 90 words
A method for determining the coagulation time for a body of fluid, supported on a non-wettable surface, following the intermixing of a coagulation agent with said fluid, comprising the steps of drawing a filament through said fluid body at a predetermined rate, and detecting when said body clings to said filament and commences to move therewith along and upon said surface, the interval between intermixing of said fluid and agent and the commencement of movement of said body bearing a direct relation to the actual coagulation time of said fluid.
Claim 3
Dependent Claim 26 words
The method of claim 1 in which said filament is fibrous, at least some of the fibers thereof having end portions projecting outwardly from said filament.
Claim 4
Dependent Claim 35 words
The method of claim 1 wherein there is the further step of measuring the time interval between the intermixing of said fluid and agent and the commencement of movement of said body along said surface.
Claim 5
Dependent Claim 12 words
The method of claim 1 in which said surface is generally smooth.
Claim 6
Dependent Claim 28 words
The method of claim 1 in which said detecting step includes detecting the interruption of a beam of light by said body upon movement thereof by said filament.
Claim 7
Independent Claim 74 words
A method for determining the coagulation time of a fluid following the addition of a coagulating agent thereto, comprising the steps of supporting a body of said fluid upon a non-wettable surface, introducing a coagulating agent into said body to initiate a coagulation reaction, simultaneously drawing a filament at a predetermined velocity through said body, and detecting when said body clings to said filament and commences to move therewith along and upon said surface.
Claim 8
Independent Claim 74 words
A method for determining the coagulation time of a fluid following the addition of a coagulating agent thereto, comprising the steps of supporting a body of said fluid upon a non-wettable surface, introducing a coagulating agent into said body to initiate a coagulation reaction, simultaneously drawing a filament at a predetermined velocity through said body, and detecting when said body clings to said filament and commences to move therewith along and upon said surface.
Claim 9
Dependent Claim 25 words
The method of claim 6 wherein said filament is fibrous, at least some of the fibers thereof having end portions projecting outwardly from said filament.
Claim 10
Dependent Claim 35 words
The method of claim 6 wherein there is the further step of measuring the time interval between the intermixing of said fluid and agent and the commencement of movement of said body along said surface.
Claim 11
Dependent Claim 13 words
The method of claim 6 in which said detecting step is performed photoelectrically.
Claim 12
Dependent Claim 30 words
The method of claim 9 in which said photoelectric detection includes the interruption of a beam of light by said body as the same commences to move with said filament.
Claim 13
Independent Claim 91 words
An apparatus for determining the coagulation time of a fluid following the intermixing of that fluid with a coagulating agent, said apparatus having a non-wettable surface having a portion for supporting a liquid body consisting essentially of a mixture of said fluid and agent, said surface also providing a pathway leading from said supporting portion, a filament, means supporting said filament for movement along a line extending over said supporting portion and along said pathway, and means coacting with said first-mentioned means for longitudinally moving said filament at a predetermined rate.
Claim 14
Independent Claim 91 words
An apparatus for determining the coagulation time of a fluid following the intermixing of that fluid with a coagulating agent, said apparatus having a non-wettable surface having a portion for supporting a liquid body consisting essentially of a mixture of said fluid and agent, said surface also providing a pathway leading from said supporting portion, a filament, means supporting said filament for movement along a line extending over said supporting portion and along said pathway, and means coacting with said first-mentioned means for longitudinally moving said filament at a predetermined rate.
Claim 15
Dependent Claim 28 words
The apparatus of claim 11 in which means are provided for detecting when said body clings to said filament and commences to move along and upon said pathway.
Claim 16
Dependent Claim 26 words
The apparatus of claim 11 in which said filament is fibrous, at least some of the fibers thereof having end portions projecting outwardly from said filament.
Claim 17
Dependent Claim 42 words
The apparatus of claim 12 in which said detecting means includes a light source for directing a beam towards said pathway, and a photocell for detecting the interruption of said beam by said body as the same commences movement along said pathway.

References Cited (Backward Citations)

US3020748A Cited
US3267362A Cited
US3267364A Cited
US3267363A Cited
US3814585A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-07-11 1981-01-10 1981-07-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-07-11 1985-01-10 1985-07-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-07-11 1989-01-10 1989-07-12 $7700.00 Window Closed / Lapsed

Assigned Categories & Tags

No categories assigned to this patent yet.

Assign Category Tag