US4029797A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process of making cough syrup with masked noscapine
Assignee: Fisons Corp
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Filing: 1973-06-20
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Granted: 1977-06-14
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Expires: 1993-06-20
Abstract
Abstract A process of utilizing the drug noscapine in a palatable cough syrup which masks the characteristic unpalatable taste of the drug comprising the steps of preparing an alkaline carrier and adding noscapine in a form which is a non-acidic solution, but rather in suspension which is finely dispersed.
Inventors
- 👤 Virgil D. Bianculli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:17
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
89 words
A method of preparing a palatable-tasting cough syrup formulation containing noscapine, which method comprises: a. preparing an aqueous liquid syrup-type carrier solution for the noscapine, which carrier includes a buffer to maintain the pH of the liquid carrier above a pH of 7 at all times; and b. mixing alkaloid noscapine in the absence of noscapine in salt form with the liquid carrier to form a fine suspension of the alkaloid noscapine therein, thereby providing a palatable-tasting liquid formulation of suspended noscapine essentially free of any bitter-tasting noscapine salts.
Claim 2
Independent Claim
89 words
A method of preparing a palatable-tasting cough syrup formulation containing noscapine, which method comprises: a. preparing an aqueous liquid syrup-type carrier solution for the noscapine, which carrier includes a buffer to maintain the pH of the liquid carrier above a pH of 7 at all times; and b. mixing alkaloid noscapine in the absence of noscapine in salt form with the liquid carrier to form a fine suspension of the alkaloid noscapine therein, thereby providing a palatable-tasting liquid formulation of suspended noscapine essentially free of any bitter-tasting noscapine salts.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the buffer is sodium citrate.
Claim 4
Dependent Claim
28 words
The method of claim 1 which includes diluting the liquid formulation so prepared with water to provide a cough syrup containing a cough-depressant amount of the suspended noscapine.
Claim 5
Dependent Claim
22 words
The method of claim 1 wherein the aqueous liquid carrier comprises sucrose, sorbitol, a preservative, carboxymethyl cellulose, glycerin and a suspending agent.
Claim 6
Dependent Claim
27 words
The method of claim 1 wherein the noscapine is powdered form is mixed with a glycerine-containing solution, and the said solution is admixed into the carrier solution.
Claim 7
Dependent Claim
94 words
The method of claim 1 wherein the liquid carrier solution is prepared by mixing a water solution of sorbitol and a syrup with a water solution of methylparaben and propylparaben and sodium citrate as a buffer, and heating the solution, and, thereafter, adding to the heated mixed solution a water solution with carboxymethyl cellulose, and, thereafter, adding to the mixed solution a heated water solution containing a suspending agent, and mixing into the carrier solution so prepared a solution of glycerin and a flavoring solution in which is suspended powdered noscapine in alkaloid form.
References Cited (Backward Citations)
US1048711A
Cited
US3108041A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |