US4029773A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and method of treating ulcers
Assignee: Syntex USA LLC
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Filing: 1973-05-25
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Granted: 1977-06-14
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Expires: 1993-05-25
Abstract
Abstract Compositions and method for treating, or reducing the occurrence, of stomach and duodenum ulcers. The compositions and methods are characterized by the administration of a composition containing (dry weight basis) 10 to 40% sucrose; 10 to 40% glucose; 12 to 20% amino acids and 7.5 to 12% lipids. The composition is typically administered orally as an aqueous liquid emulsion.
Inventors
- 👤 Myron A. Beigler
- 👤 Ronald J. Amen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:34
CPC Classifications
A; A61; A61K; A61K31/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
138 words
A composition, useful in the treatment and prevention of gastric intestinal ulcers, comprising from 10 to 40% wt. sucrose; 10 to 40% wt. glucose; 12 to 20% wt. amino acid mixture containing at least all of the essential amino acids, or pharmaceutically acceptable salts thereof, in the same relative ratio to each other as the essential amino acids are found in naturally occurring proteins; and 7.5 to 12% wt. lipid selected from the group consisting of soybean oil, corn oil, safflower oil, peanut oil, cotton seed oil, and a mixture thereof; said composition having an aqueous emulsion osmolality of about from 400 to 1500 milliosmols per kg., at a concentration of 0.1 to 0.5 g. of said composition per ml. wherein at least 50% of said composition is composed of said sucrose, glucose, amino acid mixture and lipid.
Claim 2
Dependent Claim
138 words
A composition, useful in the treatment and prevention of gastric intestinal ulcers, comprising from 10 to 40% wt. sucrose; 10 to 40% wt. glucose; 12 to 20% wt. amino acid mixture containing at least all of the essential amino acids, or pharmaceutically acceptable salts thereof, in the same relative ratio to each other as the essential amino acids are found in naturally occurring proteins; and 7.5 to 12% wt. lipid selected from the group consisting of soybean oil, corn oil, safflower oil, peanut oil, cotton seed oil, and a mixture thereof; said composition having an aqueous emulsion osmolality of about from 400 to 1500 milliosmols per kg., at a concentration of 0.1 to 0.5 g. of said composition per ml. wherein at least 50% of said composition is composed of said sucrose, glucose, amino acid mixture and lipid.
Claim 3
Dependent Claim
24 words
The composition of claim 1 wherein said composition also comprises a pharmaceutically acceptable emulsifying agent in an amount of less than 1% by wt.
Claim 4
Dependent Claim
29 words
The composition of claim 2 wherein said emulsifying agent is selected from the group consisting of carrageenans, starches, food-grade gums of polysaccharide structure, monoglycerides, diglycerides, lecithin and mixtures thereof.
Claim 5
Dependent Claim
22 words
The composition of claim 1 wherein said amino acid mixture includes at least one non-essential amino acid or pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
20 words
The composition of claim 1 wherein said amino acid mixture has the same essential amino acid pattern as egg albumin.
Claim 7
Dependent Claim
35 words
The composition of claim 1 wherein said composition comprises from 25 to 35% wt. sucrose; 25 to 35% wt. glucose; 15 to 20% wt. of said amino acid mixture and 9 to 11% said lipid.
Claim 8
Dependent Claim
64 words
The composition of claim 4 wherein said composition contains about 34.5% wt. sucrose; 34.5% wt. glucose; 10% wt. soybean oil; and about 17.7% of said amino acid mixture and wherein said essential amino acid has the pattern of egg albumin and wherein said non-essential amino acid is selected from the group consisting of 1-glutamine; glycine; sodium-1-aspartate; 1-serine; 1-alanine; 1-proline; 1-cystine; 1-tyrosine and mixtures thereof.
Claim 9
Dependent Claim
61 words
A liquid composition, useful in the treatment and prevention of gastric intestinal ulcers, having an osmolality of about from 400 to 1500 milliosmols per kg. consisting essentially of the composition of claim 1 in mixture with a pharmaceutically acceptable liquid medium in a ratio such that 1 ml. of said composition has an energy of about from 0.5 through 2 kilocal.
Claim 10
Dependent Claim
23 words
The liquid composition of claim 8 wherein said amino acid mixture includes at least one non-essential amino acid or pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
21 words
The liquid composition of claim 8 wherein said amino acid mixture has the same essential amino acid pattern as egg albumin.
Claim 12
Dependent Claim
27 words
The liquid composition of claim 8 wherein said composition contains a pharmaceutically acceptable emulsifying agent, in an amount of less than 1% on a dry wt. basis.
Claim 13
Dependent Claim
31 words
The liquid composition of claim 11 wherein said emulsifying agent is selected from the group consisting of carrageenans, starches, food-grade gums of polysaccharide structure, mono- and diglycerides, lecithin and mixtures thereof.
Claim 14
Dependent Claim
11 words
The composition of claim 8 wherein said liquid medium is water.
Claim 15
Dependent Claim
62 words
A liquid composition, useful in the treatment and prevention of gastric intestinal ulcers, having an osmolality of about from 400 to 1500 milliosmols per kg. consisting essentially of the composition of claim 7 in mixture with a pharmaceutically acceptable liquid medium in a ratio such that 1 ml. of said composition has an energy content of about from 0.5 through 2 kilcal.
Claim 16
Dependent Claim
34 words
A method for healing ulcers occurring in the stomach or duodenum of mammals which comprises orally administering to mammals having stomach ulcers or duodenal ulcer an effective amount of the composition of claim 8.
Claim 17
Dependent Claim
34 words
The method of claim 15 wherein said composition is administered to human beings in a dosage range of about from 60 to 300 grams of said composition on a dry wt. basis per day.
Claim 18
Dependent Claim
26 words
The method of claim 15 wherein said composition is administered in a dosage range of about from 10 to 300 grams dry wt. basis per day.
Claim 19
Dependent Claim
12 words
The method of claim 15 wherein said composition is administered to pigs.
Claim 20
Dependent Claim
40 words
A method of reducing the occurrance of stomach ulcers and duodenal ulcers in mammals which comprises orally administering a prophylactically effective amount of the composition of claim 8 to mammals which have a susceptibility to stomach ulcers or duodenal ulcers.
Claim 21
Dependent Claim
29 words
The method of claim 19 wherein said composition is administered to human beings in a dosage of about from 10 to 200 grams of said composition dry wt. basis.
Claim 22
Dependent Claim
26 words
The method of claim 19 wherein said composition is administered in a dosage range of about from 10 to 300 grams dry wt. basis per day.
Claim 23
Dependent Claim
12 words
The method of claim 19 wherein said composition is administered to pigs.
References Cited (Backward Citations)
US3697287A
Cited
US3773930A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |