US4011046A
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Liquid crystal quantitative analysis method for optically active compounds
Assignee: Temple University
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Filing: 1975-11-12
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Granted: 1977-03-08
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Expires: 1995-11-12
Abstract
Abstract Using a standardized cell containing a thin layer of an aligned nematic liquid crystalline material, a relationship is determined between concentration of an optically active solute material in the liquid crystal layer and line spacing in a pattern produced by differential light refraction, upon the injection of different amounts of the optically active compound. Subsequently, quantitative analysis of a sample containing the optically active compound is accomplished by injecting a known amount of the sample into a second identical standardized cell, observing the line spacing of refracted light in the second cell and comparing it to the relationship determined in the first cell. Optically active compounds analyzable in this manner include steroids and cholesteryl esters. A preferred nematic liquid crystalline material is n-p-methoxybenzylidene-p-n-butylaniline. A specific system described consists of cholesteryl-2-methyl valerate in homeotropically aligned n-p-methoxybenzylidene-p-n butylaniline with a layer thickness in the cell of 12.7 microns.
Inventors
- 👤 Mortimer M. Labes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:28
CPC Classifications
G; G02; G02F; G02F1/00; G02F1/0009; G02F1/0063; G01; G01N; G01N21/00; G01N21/17; G01N21/41; G01N21/45; Y; Y10; Y10T; Y10T436/00; Y10T436/14; Y10T436/141111; Y10T436/17; Y10T436/173845
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
127 words
Method for quantitatively analyzing a sample, for a specific optically active compound contained therein, by first determining the relationship between line spacing of differentially refracted light and concentration of said optically active compound in a nematic liquid crystalline material oriented in a first standardized cell consisting of a thin layer of said liquid crystalline material disposed between transparent cell face members, and subsequently injecting a preselected amount of said sample into the nematic liquid crystalline layer of a second standardized cell identical with said first cell, observing the line spacing of refracted light in said second cell and comparing it to the relationship determined in said first cell and, on the basis of said comparison, determining the quantity of said optically active compound in said second cell.
Claim 2
Dependent Claim
127 words
Method for quantitatively analyzing a sample, for a specific optically active compound contained therein, by first determining the relationship between line spacing of differentially refracted light and concentration of said optically active compound in a nematic liquid crystalline material oriented in a first standardized cell consisting of a thin layer of said liquid crystalline material disposed between transparent cell face members, and subsequently injecting a preselected amount of said sample into the nematic liquid crystalline layer of a second standardized cell identical with said first cell, observing the line spacing of refracted light in said second cell and comparing it to the relationship determined in said first cell and, on the basis of said comparison, determining the quantity of said optically active compound in said second cell.
Claim 3
Dependent Claim
38 words
Method, as recited in claim 1, wherein the thickness of said nematic liquid crystalline layer is from 6 to 150 microns and the side dimensions of the aligned liquid crystalline layer area is from 0.2 to 3 centimeters.
Claim 4
Dependent Claim
21 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is a nematogenic Schiff base, such as n-p-methoxybenzylidene-p-n-butyl aniline.
Claim 5
Dependent Claim
20 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is a compensated mixture of cholesteric liquid crystals.
Claim 6
Dependent Claim
25 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is a mixture of cholesteryl chloride and cholesteryl myristate, compensated at 43° C.
Claim 7
Dependent Claim
17 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is a substituted azoxybenzene nematogen.
Claim 8
Dependent Claim
15 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is p-methoxy-p'-n-butyl azoxybenzene.
Claim 9
Dependent Claim
17 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is substituted phenyl-4-benzoyl oxy benzoate.
Claim 10
Dependent Claim
16 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is substituted benzoyloxy benzoate.
Claim 11
Dependent Claim
16 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is a substituted biphenyl.
Claim 12
Dependent Claim
15 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is p-n-heptyl-p' cyanobiphenyl.
Claim 13
Dependent Claim
20 words
Method, as recited in claim 1, wherein said liquid crystalline material is a mixture of one or more nematogenic materials.
Claim 14
Dependent Claim
15 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is homeotropically aligned.
Claim 15
Dependent Claim
15 words
Method, as recited in claim 1, wherein said nematic liquid crystalline material is homogeneously aligned.
Claim 16
Dependent Claim
15 words
Method, as recited in claim 1, wherein said optically active compound is a steroidal compound.
Claim 17
Dependent Claim
15 words
Method, as recited in claim 1, wherein said optically active compound is a cholesteryl derivative.
Claim 18
Dependent Claim
14 words
Method, as recited in claim 1, wherein said optically active compound is cholesteryl-2-methyl valerate.
Claim 19
Dependent Claim
16 words
Method, as recited in claim 1, wherein said optically active compound is an optically active amphetamine.
Claim 20
Dependent Claim
15 words
Method, as recited in claim 1, wherein said optically active compound is optically active dextroamphetamine.
Claim 21
Dependent Claim
17 words
Method, as recited in claim 1, wherein said optically active compound is an optically active organic acid.
Claim 22
Dependent Claim
16 words
Method, as recited in claim 1, wherein said optically active compound is optically active tartaric acid.
Claim 23
Dependent Claim
15 words
Method, as recited in claim 1, wherein said optically active compound is an alkaloid compound.
Claim 24
Dependent Claim
15 words
Method, as recited in claim 1, wherein said optically active compound is a morphine alkaloid.
Claim 25
Dependent Claim
15 words
Method, as recited in claim 1, wherein said optically active compound is an indole alkaloid.
Claim 26
Dependent Claim
15 words
Method, as recited in claim 1, wherein said optically active compound is a cinchona alkaloid.
Claim 27
Dependent Claim
15 words
Method, as recited in claim 1, wherein said optically active compound is an ergot alkaloid.
Claim 28
Dependent Claim
13 words
Method, as recited in claim 1, wherein said optically active compound is morphine.
Claim 29
Dependent Claim
13 words
Method, as recited in claim 1, wherein said optically active compound is codeine.
Claim 30
Dependent Claim
17 words
Method, as recited in claim 1, wherein said optically active compound is an optically active terpenoid alcohol.
Claim 31
Dependent Claim
17 words
Method, as recited in claim 1, wherein said optically active compounds is a chiral nematic liquid crystal.
Claim 32
Dependent Claim
20 words
Method, as recited in claim 1, wherein said optically active compound is an optically active sugar compound or sugar derivative.
References Cited (Backward Citations)
No citation records indexed.
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