US4010251A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Scanning agent composition and use in imaging liver and for biliary function
Assignee: Individual
•
Filing: 1974-12-16
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Granted: 1977-03-01
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Expires: 1994-12-16
Abstract
Abstract A composition to be used in a method for imaging liver and for biliary function, the composition comprising a scanning agent that is combined with a radioisotope. The scanning agent is preferably a glycoprotein whose glycosidic side chains terminate in a sialic acid moiety followed by a galactose as exemplified by gamma globulin. The preferred radioisotope is technetium ( 99m Tc). The composition of the invention will bind to hepatocyte (liver cell) membranes whereas most known pertechnetated hepatic scanning agents attach to the reticuloendothelial cells of the liver (Kuppfer cells) with the advantage being that the present composition will be excreted into the bile ducts and make its way to the intestines, thus acting as an indicator of biliary tree patency. The composition has been administered to human subjects and animals for liver imaging using the anger camera as well as for evaluating the biliary function.
Inventors
- 👤 Allan M. Green
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:30
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K2123/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
40 words
A scanning agent composition comprising glycoproteins and glycopeptides having glycosidic side chains terminating in a sialic acid moiety followed by a galactose, said glycoproteins and glycopeptides having been desialylated and chemically combined with a compatible radioisotope suitable for hepatobiliary imaging.
Claim 2
Dependent Claim
40 words
A scanning agent composition comprising glycoproteins and glycopeptides having glycosidic side chains terminating in a sialic acid moiety followed by a galactose, said glycoproteins and glycopeptides having been desialylated and chemically combined with a compatible radioisotope suitable for hepatobiliary imaging.
Claim 3
Dependent Claim
11 words
The composition of claim 1 wherein the glycoprotein is gamma globulin.
Claim 4
Dependent Claim
11 words
The composition of claim 1 wherein the radioisotope is 99m Tc.
Claim 5
Dependent Claim
23 words
The composition of claim 1 wherein the radioisotope is selected from the group consisting of 111 In, 113m In, 131 I and 99m
Claim 6
Dependent Claim
17 words
The composition of claim 1 wherein the glycoprotein is gamma globulin and the radioisotope is 99m Tc.
Claim 7
Dependent Claim
52 words
In a method for imaging liver comprising injecting an effective amount of a scanning agent composition comprising glycoproteins and glycopeptides having glycosidic side chains terminating in a sialic acid moiety followed by a galactose, said glycoproteins and glycopeptides having been desialylated and chemically combined with a compatible radioisotope suitable for hepatobiliary imaging.
Claim 8
Dependent Claim
52 words
In a method for imaging liver comprising injecting an effective amount of a scanning agent composition comprising glycoproteins and glycopeptides having glycosidic side chains terminating in a sialic acid moiety followed by a galactose, said glycoproteins and glycopeptides having been desialylated and chemically combined with a compatible radioisotope suitable for hepatobiliary imaging.
Claim 9
Dependent Claim
11 words
The method of claim 6 wherein the glycoprotein is gamma globulin.
Claim 10
Dependent Claim
11 words
The method of claim 6 wherein the radioisotope is 99m Tc.
Claim 11
Dependent Claim
24 words
The method of claim 6 wherein the glycoprotein is selected from the group consisting of 111 In, 113m In, 131 I, and 99m Tc.
Claim 12
Dependent Claim
16 words
The method of claim 6 wherein the glycoprotein is gamma globulin and the radioisotope is 99mTc.
Claim 13
Dependent Claim
52 words
In a method for determining biliary function comprising injecting an effective amount of a scanning composition comprising glycoproteins and glycopeptides having glycosidic side chains terminating in a sialic acid moiety followed by a glactose, said glycoproteins and glycopeptides having been desialylated and chemically combined with a compatible radioisotope suitable for hepatobiliary imaging.
Claim 14
Dependent Claim
52 words
In a method for determining biliary function comprising injecting an effective amount of a scanning composition comprising glycoproteins and glycopeptides having glycosidic side chains terminating in a sialic acid moiety followed by a glactose, said glycoproteins and glycopeptides having been desialylated and chemically combined with a compatible radioisotope suitable for hepatobiliary imaging.
Claim 15
Dependent Claim
11 words
The method of claim 11 wherein the glycoprotein is gamma globulin.
Claim 16
Dependent Claim
11 words
The method of claim 11 wherein the radioisotope is 99m Tc.
Claim 17
Dependent Claim
17 words
The method of claim 11 wherein the glycoprotein is gamma globulin and the radioisotope is 99m Tc.
Claim 18
Dependent Claim
16 words
The method of claim 11 wherein the glycoprotein is orosomucoid and the radioisotope is 99m Tc.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-29 | 1980-08-30 | 1981-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-29 | 1984-08-30 | 1985-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-29 | 1988-08-30 | 1989-03-01 | $7700.00 | Window Closed / Lapsed |