US4001142A
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Blood gas control
Assignee: PARKE DAVIS LABORATORIES
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Filing: 1975-07-25
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Granted: 1977-01-04
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Expires: 1995-07-25
Abstract
Abstract Disclosed are a stable, non-protein, buffered control material for monitoring the reliability of blood gas instruments in the acid, normal, and alkaline ranges.
Inventors
- 👤 James E. Turner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:38
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N2496/00; G01N2496/15; G01N2496/70; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499; Y10T436/108331
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
40 words
A liquid composition of matter for use as a blood gas control which comprises water, a dye, a buffering agent, a lower alkyl acid, a source of bicarbonate ion and an amount of dissolved oxygen, carbon dioxide and nitrogen gas.
Claim 2
Dependent Claim
40 words
A liquid composition of matter for use as a blood gas control which comprises water, a dye, a buffering agent, a lower alkyl acid, a source of bicarbonate ion and an amount of dissolved oxygen, carbon dioxide and nitrogen gas.
Claim 3
Dependent Claim
26 words
The composition of claim 1 wherein the buffering agent is triethanolamine, wherein the acid is acetic acid, and wherein the source of bicarbonate is sodium bicarbonate.
Claim 4
Dependent Claim
22 words
The composition of claim 2 wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 30.24.
Claim 5
Dependent Claim
15 words
The composition of claim 2 wherein the dye is F, D and C yellow dye.
Claim 6
Dependent Claim
22 words
The composition of claim 2 wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 5.0.
Claim 7
Dependent Claim
24 words
The composition of claim 5 wherein the dye is selected from the group consisting of F, D and C yellow dye and amaranth dye.
Claim 8
Dependent Claim
23 words
The composition according to claim 2 wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 81.91.
Claim 9
Independent Claim
101 words
The method for preparing a liquid blood gas control which comprises: Filtering a quantity of deionized water through a 0.22 μ filter membrane; Dissolving a quantity of a dye and triethanolamine in the filtered water; Adjusting the solution so obtained to a pH range of about 7.1 to 7.6; Dissolving a quantity of sodium bicarbonate in the pH adjusted solution; Placing the solution so obtained in a glass ampul; Flushing the ampul with a gas mixture comprising oxygen, carbon dioxide and nitrogen; Sealing the ampul to effect an air tight seal; and Sterilizing the ampul immediately after sealing in an autoclave.
Claim 10
Independent Claim
101 words
The method for preparing a liquid blood gas control which comprises: Filtering a quantity of deionized water through a 0.22 μ filter membrane; Dissolving a quantity of a dye and triethanolamine in the filtered water; Adjusting the solution so obtained to a pH range of about 7.1 to 7.6; Dissolving a quantity of sodium bicarbonate in the pH adjusted solution; Placing the solution so obtained in a glass ampul; Flushing the ampul with a gas mixture comprising oxygen, carbon dioxide and nitrogen; Sealing the ampul to effect an air tight seal; and Sterilizing the ampul immediately after sealing in an autoclave.
Claim 11
Dependent Claim
38 words
A liquid composition or matter for use as a blood gas control which comprises water, a buffering agent, a lower alkyl acid, a source of bicarbonate ion and an amount of dissolved oxygen, carbon dioxide and nitrogen gas.
Claim 12
Dependent Claim
38 words
A liquid composition or matter for use as a blood gas control which comprises water, a buffering agent, a lower alkyl acid, a source of bicarbonate ion and an amount of dissolved oxygen, carbon dioxide and nitrogen gas.
Claim 13
Dependent Claim
56 words
A composition of matter for use as a blood gas control which comprises water, triethanolamine acetic acid, sodium bicarbonate, and a gas mixture comprising oxygen in an amount of about 6.6 to about 21.9%, carbon dioxide in an amount of about 6.09 to about 6.75%, and nitrogen in an amount of about 71.35 to about 87.31%.
Claim 14
Dependent Claim
56 words
A composition of matter for use as a blood gas control which comprises water, triethanolamine acetic acid, sodium bicarbonate, and a gas mixture comprising oxygen in an amount of about 6.6 to about 21.9%, carbon dioxide in an amount of about 6.09 to about 6.75%, and nitrogen in an amount of about 71.35 to about 87.31%.
Claim 15
Dependent Claim
70 words
A composition of matter for use as a blood gas control which comprises water, F D, and C yellow dye, triethanolamine, sodium bicarbonate, acetic acid, an amount of dissolved gas comprising about 13% oxygen, about 6.4% carbon dioxide and about 80.6% nitrogen, and wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 30.24 and wherein the pH of the composition is about 7.4.
Claim 16
Dependent Claim
70 words
A composition of matter for use as a blood gas control which comprises water, F D, and C yellow dye, triethanolamine, sodium bicarbonate, acetic acid, an amount of dissolved gas comprising about 13% oxygen, about 6.4% carbon dioxide and about 80.6% nitrogen, and wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 30.24 and wherein the pH of the composition is about 7.4.
Claim 17
Dependent Claim
83 words
A composition of matter for use as a blood gas control which comprises water, a dye selected from the group consisting of F D, and C yellow dye and F, and C Red No. 2, triethanolamine, acetic acid, sodium bicarbonate, and an amount of dissolved gas comprising 21.9% oxygen, 6.09% carbon dioxide and 72.01% nitrogen, and wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 5.0, and wherein the pH of the composition is about 7.1.
Claim 18
Dependent Claim
83 words
A composition of matter for use as a blood gas control which comprises water, a dye selected from the group consisting of F D, and C yellow dye and F, and C Red No. 2, triethanolamine, acetic acid, sodium bicarbonate, and an amount of dissolved gas comprising 21.9% oxygen, 6.09% carbon dioxide and 72.01% nitrogen, and wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 5.0, and wherein the pH of the composition is about 7.1.
Claim 19
Dependent Claim
83 words
A composition of matter for use as a blood gas control which comprises water, a dye selected from the group consisting of F D, and C yellow dye and CIF Blue No. 2, triethanolamine, acetic acid, sodium bicarbonate, an amount of dissolved gas comprising about 6.6% oxygen, about 6.75% carbon dioxide and about 86.65% nitrogen, and wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 81.91 and wherein the pH of the composition is about 7.6.
Claim 20
Dependent Claim
83 words
A composition of matter for use as a blood gas control which comprises water, a dye selected from the group consisting of F D, and C yellow dye and CIF Blue No. 2, triethanolamine, acetic acid, sodium bicarbonate, an amount of dissolved gas comprising about 6.6% oxygen, about 6.75% carbon dioxide and about 86.65% nitrogen, and wherein the ratio of dye to triethanolamine to sodium bicarbonate is about 1 : 223.8 : 81.91 and wherein the pH of the composition is about 7.6.
Claim 21
Dependent Claim
64 words
A package for use in containing a liquid composition having a predetermined pH, oxygen concentration and carbon dioxide concentration which comprises: A sealed glass ampul wherein the seal is impermeable to air, and A liquid composition of matter comprising water, a dye, triethanolamine, acetic acid, sodium bicarbonate and a predetermined concentration of oxygen, carbon dioxide, and nitrogen, and wherein said liquid concentration is sterile.
Claim 22
Dependent Claim
64 words
A package for use in containing a liquid composition having a predetermined pH, oxygen concentration and carbon dioxide concentration which comprises: A sealed glass ampul wherein the seal is impermeable to air, and A liquid composition of matter comprising water, a dye, triethanolamine, acetic acid, sodium bicarbonate and a predetermined concentration of oxygen, carbon dioxide, and nitrogen, and wherein said liquid concentration is sterile.
Claim 23
Dependent Claim
26 words
The composition of claim 1 wherein the dye is selected from the group of F, D and C Yellow No. 5 and CIF Blue No. 2.
Claim 24
Dependent Claim
35 words
The compound of claim 1 in which the dye is selected from the group consisting of F, D and C Yellow No. 5, F, D and C Red No. 2 and CIF Blue No. 2.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-04 | 1980-07-05 | 1981-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-04 | 1984-07-05 | 1985-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-04 | 1988-07-05 | 1989-01-04 | $7700.00 | Window Closed / Lapsed |