US3989622A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Urease in insoluble form for converting urea present in a liquid
Assignee: Cci Life Systems Inc
•
Filing: 1973-05-21
•
Granted: 1976-11-02
•
Expires: 1993-05-21
Abstract
Abstract Urease is adsorbed in an aqueous environment on a urease retaining material selected from the group comprising aluminum oxide and magnesium silicate and is thereafter insoluble so that when contacted by liquid containing urea, the urea is converted into ammonium carbonate while the urease remains adsorbed on the retaining material.
Inventors
- 👤 Laurence B. Marantz
- 👤 Mario G. Giorgianni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:44
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/14; A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1694; A61M1/1696; B; B01; B01J; B01J39/00; B01J39/08; B01J39/12
Claims Analysis
Total Claims: 54
Claim 1
Independent Claim
86 words
A substance for converting dissolved urea present in a liquid; means for locating said substance in said liquid; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 2
Dependent Claim
86 words
A substance for converting dissolved urea present in a liquid; means for locating said substance in said liquid; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 3
Dependent Claim
40 words
The combination of claim 1 wherein said substance is initially a mixture of dry granules of urease and said urease retaining material; and said adsorption of urease on said retaining material resulting from contact of said granules with said liquid.
Claim 4
Dependent Claim
30 words
The combination of claim 1 wherein said urease retaining material is initially in dry granular form, said urease being adsorbed on said material granules from a liquid solution of urease.
Claim 5
Dependent Claim
10 words
The combination of claim 1 wherein said liquid contains water.
Claim 6
Dependent Claim
23 words
A combination of claim 1 wherein said liquid is dialysate solution containing urea picked up from a patient and being substantially all water.
Claim 7
Dependent Claim
13 words
The combination of claim 5, wherein said dialysate solution is a hemodialysate solution.
Claim 8
Dependent Claim
14 words
The combination of claim 5, wherein said dialysate solution is a peritoneal dialysate solution.
Claim 9
Dependent Claim
76 words
A substance for converting dissolved urea present in a liquid; means for locating said substance in said liquid; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material consisting of aluminum oxide.
Claim 10
Dependent Claim
76 words
A substance for converting dissolved urea present in a liquid; means for locating said substance in said liquid; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material consisting of aluminum oxide.
Claim 11
Dependent Claim
76 words
A substance for converting dissolved urea present in a liquid; means for locating said substance in said liquid; said substance comprising a urease retaining material having urease absorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material consisting of magnesium silicate.
Claim 12
Dependent Claim
76 words
A substance for converting dissolved urea present in a liquid; means for locating said substance in said liquid; said substance comprising a urease retaining material having urease absorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material consisting of magnesium silicate.
Claim 13
Dependent Claim
99 words
A container containing a substance for converting dissolved urea present in a liquid; said container being penetratable by said liquid to permit said liquid to contact said subtance in said container; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 14
Dependent Claim
99 words
A container containing a substance for converting dissolved urea present in a liquid; said container being penetratable by said liquid to permit said liquid to contact said subtance in said container; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 15
Dependent Claim
10 words
The combination of claim 10 wherein said liquid contains water.
Claim 16
Dependent Claim
23 words
The combination of claim 10 wherein said liquid is dialysate solution containing urea picked up from a patient and being substantially all water.
Claim 17
Dependent Claim
13 words
The combination of claim 12, wherein said dialysate solution is a hemodialysate solution.
Claim 18
Dependent Claim
14 words
The combination of claim 12, wherein said dialysate solution is a peritoneal dialysate solution.
Claim 19
Dependent Claim
42 words
A container as defined in claim 10 having first opening means for introducing liquid into said container; and second opening means for discharging said liquid from said container after conversion of urea in said liquid to ammonium carbonate by the adsorbed urease.
Claim 20
Dependent Claim
33 words
A container as defined in claim 15 wherein said substance is permeable to said liquid and is located between said first and second opening means so that said liquid flows through said substance.
Claim 21
Dependent Claim
31 words
The combination of claim 16 having urease retaining material located between said substance and said second opening means for adsorbing urease not adsorbed on the urease retaining material comprising said substance.
Claim 22
Dependent Claim
23 words
The combination of claim 16 wherein said liquid is circulating dialysate solution returning from an artificial kidney and entering said first passage means.
Claim 23
Dependent Claim
33 words
The combination of claim 18 having an ammonium ion sorbent material located between said substance and said second opening means, so that the dialysate solution flows from said substance into said sorbent material.
Claim 24
Dependent Claim
30 words
The combination of claim 16 wherein said substance is maintained in said container in layer form located between said two opening means and in the flow path of said liquid.
Claim 25
Dependent Claim
31 words
The combination of claim 20 having a second layer of urease retaining material located between said substance layer and said second opening means to absorb any urease leaving said substance layer.
Claim 26
Dependent Claim
89 words
A container containing a substance for converting dissolved urea present in a liquid; said container being penetratable by said liquid to permit said liquid to contact said substance in said container; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material consisting of aluminum oxide.
Claim 27
Dependent Claim
89 words
A container containing a substance for converting dissolved urea present in a liquid; said container being penetratable by said liquid to permit said liquid to contact said substance in said container; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material consisting of aluminum oxide.
Claim 28
Dependent Claim
89 words
A container containing a substance for converting dissolved urea present in a liquid; said container being penetratable by said liquid to permit said liquid to contact said substance in said container; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material consisting of magnesium silicate.
Claim 29
Dependent Claim
89 words
A container containing a substance for converting dissolved urea present in a liquid; said container being penetratable by said liquid to permit said liquid to contact said substance in said container; said substance comprising a urease retaining material having urease adsorbed thereon for converting urea in said liquid into ammonium carbonate; said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material consisting of magnesium silicate.
Claim 30
Independent Claim
76 words
The method of converting urea dissolved in a liquid to ammonium carbonate comprising the step of contacting said liquid with a substance comprising urease retaining material having urease adsorbed thereon, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 31
Independent Claim
76 words
The method of converting urea dissolved in a liquid to ammonium carbonate comprising the step of contacting said liquid with a substance comprising urease retaining material having urease adsorbed thereon, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 32
Dependent Claim
31 words
The method of claim 24 further comprising the steps of, before said contacting step; supporting said urease retaining material in a supporting means; and adsorbing urease on said urease retaining material.
Claim 33
Dependent Claim
27 words
The method of claim 25 including the further step of, prior to said adsorbing step, mixing said urease retaining material and said urease together as dry powders.
Claim 34
Dependent Claim
24 words
The method of claim 25, wherein said step of adsorbing urease on said urease retaining material occurs in the presence of a dialysate solution.
Claim 35
Dependent Claim
24 words
The method of claim 25, wherein the step of adsorbing urease on said urease retaining material occurs in the presence of a saline solution.
Claim 36
Dependent Claim
24 words
The method of claim 25 including the further step of, after said supporting step, adding urease in liquid form to said urease retaining material.
Claim 37
Dependent Claim
18 words
The method of claim 29, wherein said urease in liquid form is urease dissolved in a dialysate solution.
Claim 38
Dependent Claim
18 words
The method of claim 29, wherein said urease in liquid form is urease dissolved in a saline solution.
Claim 39
Independent Claim
77 words
The method of converting urea dissolved in a dialysate solution to ammonium carbonate comprising the step of contacting said solution with a substance comprising urease retaining material having urease adsorbed thereon, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 40
Independent Claim
77 words
The method of converting urea dissolved in a dialysate solution to ammonium carbonate comprising the step of contacting said solution with a substance comprising urease retaining material having urease adsorbed thereon, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 41
Dependent Claim
13 words
The method of claim 32, wherein said dialysate solution is a hemodialysate solution.
Claim 42
Dependent Claim
14 words
The method of claim 32, wherein said dialysate solution is a peritoneal dialysate solution.
Claim 43
Dependent Claim
31 words
The method of claim 32 further comprising the steps of, before said contacting step; supporting said urease retaining material in a supporting means; and adsorbing urease on said urease retaining material.
Claim 44
Dependent Claim
27 words
The method of claim 35 including the further step of, prior to said adsorbing step, mixing said urease retaining material and said urease together as dry powders.
Claim 45
Dependent Claim
24 words
The method of claim 35 including the further step of, after said supporting step, adding urease in liquid form to said urease retaining material.
Claim 46
Dependent Claim
24 words
The method of claim 35, wherein said step of adsorbing urease on said urease retaining material occurs in the presence of a dialysate solution.
Claim 47
Dependent Claim
24 words
The method of claim 35, wherein said step of adsorbing urease on said urease retaining material occurs in the presence of a saline solution.
Claim 48
Dependent Claim
104 words
A cartridge for converting urea dissolved in a liquid comprising a container; a mixture located within said container of a urease retaining material and urease both in dry granular form, and opening means in said container for permitting introduction of said liquid into a mixture to produce adsorption of said urease on said urease retaining material, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 49
Dependent Claim
104 words
A cartridge for converting urea dissolved in a liquid comprising a container; a mixture located within said container of a urease retaining material and urease both in dry granular form, and opening means in said container for permitting introduction of said liquid into a mixture to produce adsorption of said urease on said urease retaining material, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material being selected from the group consisting of aluminum oxide and magnesium silicate.
Claim 50
Dependent Claim
39 words
A cartridge as defined in claim 40 wherein said container is a column, said opening means being located on one side of said mixture, and a liquid outlet in said container located on the opposite side of said mixture.
Claim 51
Dependent Claim
96 words
A cartridge for converting urea dissolved in a liquid comprising a container; a mixture located within said container of a urease retaining material and urease both in dry granular form, and opening means in said container for permitting introduction of said liquid into a mixture to produce adsorption of said urease on said urease retaining material, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material consisting of aluminum oxide.
Claim 52
Dependent Claim
96 words
A cartridge for converting urea dissolved in a liquid comprising a container; a mixture located within said container of a urease retaining material and urease both in dry granular form, and opening means in said container for permitting introduction of said liquid into a mixture to produce adsorption of said urease on said urease retaining material, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material consisting of aluminum oxide.
Claim 53
Dependent Claim
95 words
A cartridge for converting urea dissolved in a liquid comprising: a container; a mixture located within said container of a urease retaining material and urease both in dry granular form, and opening means in said container for permitting introduction of a liquid into said mixture to produce adsorption of urease on said urease retaining material, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material consisting of magnesium silicate.
Claim 54
Dependent Claim
95 words
A cartridge for converting urea dissolved in a liquid comprising: a container; a mixture located within said container of a urease retaining material and urease both in dry granular form, and opening means in said container for permitting introduction of a liquid into said mixture to produce adsorption of urease on said urease retaining material, said adsorbed urease being insoluble in said liquid so that it is not dissolved in the liquid contacting said substance and retaining its ability to convert dissolved urea into ammonium carbonate; and said urease retaining material consisting of magnesium silicate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-02 | 1980-05-03 | 1980-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-02 | 1984-05-03 | 1984-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-02 | 1988-05-03 | 1988-11-02 | $7700.00 | Window Closed / Lapsed |