US3986506A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus for separation of cryoprecipitate from blood plasma and method
Assignee: Baxter International Inc
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Filing: 1974-09-03
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Granted: 1976-10-19
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Expires: 1994-09-03
Abstract
Abstract A blood collection system which comprises several blood compatible sealed bags connected together by blood compatible conduits. Means for separating cryoprecipitate from blood plasma are provided. This separation is made by a filtering means. The filtering means is positioned in the outlet of one of the bags of the system. After the blood cells have been removed by a prior step, the remaining blood plasma is collected in the bag which has the filtering means in the outlet. In this bag, the blood plasma is frozen and then slowly thawed. Factor VIII rich cryoprecipitate forms in this bag as part of the freezing and thawing process. As the plasma melts, it flows from the bag through the filtering means. The filtering means positioned in the outlet of the bag retains the cryoprecipitate. Thus, the separation of Factor VIII rich cryoprecipitate from the blood plasma is effected.
Inventors
- 👤 Jan W. Garber
- 👤 De Wayne G. Davisson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 21:07
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/36; A61M1/369; B; B01; B01D; B01D35/00; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0445; A61M2202/0447; A61M2202/0452; A61M2205/00; A61M2205/36; A61M2205/3606; A61M2205/75; A61M2205/7545; A61M39/00; A61M39/22; A61M39/221; Y; Y10; Y10S; Y10S128/00; Y10S128/24
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
128 words
In a blood collection system which comprises blood compatible container means, including a first, blood compatible, sealed container for receiving blood, and a second, blood compatible, sealed container, communicating in sterile manner with said first container, for receiving blood plasma from said first container, the improvement comprising a filtering means within said plasma-receiving container, said filtering means comprising a depth filter made of open celled foam and being positioned to cover an outlet from said plasma-receiving container, whereby blood plasma in said plasma-receiving container may be frozen, and then thawed to form Factor VIII rich cryoprecipitate in said plasma-receiving container, and cryoprecipitate-poor plasma may be transferred from said container through said filtering means and outlet, while said cryoprecipitate is held in said second container by said filtering means.
Claim 2
Dependent Claim
128 words
In a blood collection system which comprises blood compatible container means, including a first, blood compatible, sealed container for receiving blood, and a second, blood compatible, sealed container, communicating in sterile manner with said first container, for receiving blood plasma from said first container, the improvement comprising a filtering means within said plasma-receiving container, said filtering means comprising a depth filter made of open celled foam and being positioned to cover an outlet from said plasma-receiving container, whereby blood plasma in said plasma-receiving container may be frozen, and then thawed to form Factor VIII rich cryoprecipitate in said plasma-receiving container, and cryoprecipitate-poor plasma may be transferred from said container through said filtering means and outlet, while said cryoprecipitate is held in said second container by said filtering means.
Claim 3
Dependent Claim
18 words
The blood collection system of claim 1 in which said open cell foam filter is made of polyurethane.
Claim 4
Dependent Claim
124 words
In a multiple bag blood collection system which comprises a plurality of blood-compatible, sealed bags connected together with blood compatible conduit means, and blood collection means communicating with the interior of the first of said bags, the improvement comprising: filtering means positioned within a second of said bags to cover an outlet from said second bag, said filtering means comprising a depth filter made of open celled foam, whereby blood plasma, expressed from said first bag into said second bag, may be frozen to form Factor VIII rich cryoprecipitate in said second bag, and upon thawing, cryoprecipitate-poor plasma may be transferred from said second bag through said filtering means and outlet, while said cryoprecipitate is retained in said second bag by said filtering means.
Claim 5
Dependent Claim
124 words
In a multiple bag blood collection system which comprises a plurality of blood-compatible, sealed bags connected together with blood compatible conduit means, and blood collection means communicating with the interior of the first of said bags, the improvement comprising: filtering means positioned within a second of said bags to cover an outlet from said second bag, said filtering means comprising a depth filter made of open celled foam, whereby blood plasma, expressed from said first bag into said second bag, may be frozen to form Factor VIII rich cryoprecipitate in said second bag, and upon thawing, cryoprecipitate-poor plasma may be transferred from said second bag through said filtering means and outlet, while said cryoprecipitate is retained in said second bag by said filtering means.
Claim 6
Dependent Claim
18 words
The blood collection system of claim 3 in which said open cell foam filter is made of polyurethane.
Claim 7
Dependent Claim
30 words
The blood collection system of claim 3 in which said outlet of the second bag is in fluid communication with a third bag, for receiving cryoprecipitate-poor plasma in aseptic manner.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-19 | 1980-04-19 | 1980-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-19 | 1984-04-19 | 1984-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-19 | 1988-04-19 | 1988-10-19 | $7700.00 | Window Closed / Lapsed |