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US3983245A
Expired / Lapsed
US
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Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
Assignee: GlaxoSmithKline LLC
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Filing: 1975-02-06
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Granted: 1976-09-28
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Expires: 1995-02-06
Abstract
Abstract The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of angina pectoris.
Inventors
- 👤 David L. Ladd
- 👤 Stephen T. Ross
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:31
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/08; C07C; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07D205/00; C07D205/02; C07D205/04; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/18; C07D223/00; C07D223/02; C07D223/04; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/80; C07F; C07F1/00; C07F1/08
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
91 words
A compound of the formula: ##EQU1##or a pharmaceutically acceptable acid addition salt thereof, in which: R 1 is hydrogen, chloro, bromo, trifluoromethyl or lower alkyl; R 2 is straight or branched chain alkyl of from one to six carbon atoms; R 3 is lower alkyl or phenyl(CH 2 ) p where p is 0 or 1 and the phenyl moiety is unsubstituted or substituted in the para-position with lower alkyl, lower alkoxy, halogen or trifluoromethyl; m is 1 to 4; n is 0 or 1; and Z is oxygen or sulfur.
Claim 2
Dependent Claim
91 words
A compound of the formula: ##EQU1##or a pharmaceutically acceptable acid addition salt thereof, in which: R 1 is hydrogen, chloro, bromo, trifluoromethyl or lower alkyl; R 2 is straight or branched chain alkyl of from one to six carbon atoms; R 3 is lower alkyl or phenyl(CH 2 ) p where p is 0 or 1 and the phenyl moiety is unsubstituted or substituted in the para-position with lower alkyl, lower alkoxy, halogen or trifluoromethyl; m is 1 to 4; n is 0 or 1; and Z is oxygen or sulfur.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 in which Z is oxygen.
Claim 4
Dependent Claim
18 words
A compound according to claim 2 in which R 3 is in the 2-position of the benzofuran nucleus.
Claim 5
Dependent Claim
31 words
A compound according to claim 3 in which R 1 is hydrogen and R 3 is phenyl or phenyl substituted in the para-position with lower alkyl, lower alkoxy, halogen or trifluoromethyl.
Claim 6
Dependent Claim
12 words
A compound according to claim 4 in which R 3 is phenyl.
Claim 7
Dependent Claim
21 words
A compound according to claim 5 in which R 2 is branched chain alkyl of from three to six carbon atoms.
Claim 8
Dependent Claim
12 words
A compound according to claim 6, said compound having the formula: ##SPC3##
Claim 9
Dependent Claim
21 words
A pharmaceutical composition having coronary vasodilator activity comprising a pharmaceutical carrier and an effective amount of a compound of claim 1.
Claim 10
Dependent Claim
26 words
A method of producing coronary vasolidation in an animal in need thereof comprising administering to said animal an effective amount of a compound of claim 1.
Claim 11
Dependent Claim
20 words
A pharmaceutical composition having anti-anginal activity comprising a pharmaceutical carrier and an effective amount of the compound of claim 7.
Claim 12
Dependent Claim
26 words
A method of producing anti-anginal activity in an animal in need thereof comprising administering to said animal an effective amount of the compound of claim 7.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-28 | 1980-03-29 | 1980-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-28 | 1984-03-29 | 1984-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-28 | 1988-03-29 | 1988-09-28 | $7700.00 | Window Closed / Lapsed |