Patent US2422526A successfully refreshed from Google Patents.
US3973913A
Expired / Lapsed
US
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Blood control standard
Assignee: Baxter International Inc
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Filing: 1976-01-29
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Granted: 1976-08-10
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Expires: 1996-01-29
Abstract
Abstract A stable blood control standard and method is provided for the quality control of the measurement of blood pH and gases in the clinical laboratory. The blood control standard comprises a sealed receptacle containing specially treated red cells and a gaseous head space at least equal to about the volume of the red cells. The special treatment comprises thorough washing and separating the red cells from the plasma components and mild treatment with aldehyde and retention in a buffered solution. The head space comprises from 0-15% CO 2 , 0-25% O 2 and the balance N 2 and/or inert gas.
Inventors
- 👤 Allan L. Louderback
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:44
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N2496/00; G01N2496/05; G01N2496/70; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/101666; Y10T436/102499; Y10T436/107497; Y10T436/108331
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
135 words
A blood control standard for the quality control of the measurement of blood pH and gases comprising a sealed receptacle containing treated erythrocytes and a gaseous head space having a volume which is at least equal to about the volume of said erythrocytes, said erythrocytes being treated by thorough washing in saline solution, mild admixing with a solution of aldehyde and saline, thorough washing in saline solution, buffering to a pH of from about 7 to about 7.7 and admixing with bicarbonate ion to a pCO 2 of from about 20 to about 55 mm Hg, said gaseous head space comprising from about 0% to about 15% CO 2 , from about 0% to about 25% O 2 and the balance selected from the group consisting of N 2 and inert gases and mixtures thereof.
Claim 2
Dependent Claim
135 words
A blood control standard for the quality control of the measurement of blood pH and gases comprising a sealed receptacle containing treated erythrocytes and a gaseous head space having a volume which is at least equal to about the volume of said erythrocytes, said erythrocytes being treated by thorough washing in saline solution, mild admixing with a solution of aldehyde and saline, thorough washing in saline solution, buffering to a pH of from about 7 to about 7.7 and admixing with bicarbonate ion to a pCO 2 of from about 20 to about 55 mm Hg, said gaseous head space comprising from about 0% to about 15% CO 2 , from about 0% to about 25% O 2 and the balance selected from the group consisting of N 2 and inert gases and mixtures thereof.
Claim 3
Dependent Claim
23 words
The blood control standard of claim 1 in which the aldehyde is an aliphatic aldehyde having from 1 to about 6 carbon atoms.
Claim 4
Dependent Claim
13 words
The blood control standard of claim 1 in which the aldehyde is formaldehyde.
Claim 5
Dependent Claim
16 words
The blood control standard of claim 1 in which the saline solution is normal physiological saline.
Claim 6
Dependent Claim
20 words
The blood control standard of claim 1 in which the aldehyde concentration is from about 0.1 to about 0.6 molar.
Claim 7
Dependent Claim
30 words
The blood control standard of claim 1 in which the mild admixing with aldehyde is at about 20° to about 26° C. for about 15 minutes to about 4 hours.
Claim 8
Dependent Claim
22 words
The blood control standard of claim 1 in which the buffer is selected from the group consisting of HEPES and TES buffers.
Claim 9
Dependent Claim
18 words
The blood control standard of claim 7 in which the buffer is about 0.05 to about 0.2 molar.
Claim 10
Independent Claim
143 words
The method of making a blood control standard for the quality control of the measurement of blood pH and gases comprising thoroughly washing erythrocytes in saline solution, mildly admixing with a solution of aldehyde and saline, thoroughly washing is saline solution, buffering to a pH of from about 7 to about 7.7, admixing with bicarbonate ion to a pCO 2 of from about 20 to about 55 mm Hg, transferring to receptacles while leaving a gaseous head space of at least about equal to the volume of said erythrocytes, flushing said head space with a gas comprising from about 0% to about 15% CO 2 , from about 0% to about 25% O 2 and the balance selected from the group consisting of N 2 and inert gases and mixtures thereof, and immediately thereafter sealing said receptacles to form a gas tight closure.
Claim 11
Independent Claim
143 words
The method of making a blood control standard for the quality control of the measurement of blood pH and gases comprising thoroughly washing erythrocytes in saline solution, mildly admixing with a solution of aldehyde and saline, thoroughly washing is saline solution, buffering to a pH of from about 7 to about 7.7, admixing with bicarbonate ion to a pCO 2 of from about 20 to about 55 mm Hg, transferring to receptacles while leaving a gaseous head space of at least about equal to the volume of said erythrocytes, flushing said head space with a gas comprising from about 0% to about 15% CO 2 , from about 0% to about 25% O 2 and the balance selected from the group consisting of N 2 and inert gases and mixtures thereof, and immediately thereafter sealing said receptacles to form a gas tight closure.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-10 | 1980-02-09 | 1980-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-10 | 1984-02-09 | 1984-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-10 | 1988-02-09 | 1988-08-10 | $7700.00 | Window Closed / Lapsed |