US3968241A
Expired / Lapsed
US
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Method of treating cardiac arrhythmias and of improving myocardial contractility and systolic rhythm with carnitive or a pharmaceutically acceptable salt thereof
Assignee: DEFELICE STEPHEN L
•
Filing: 1974-07-02
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Granted: 1976-07-06
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Expires: 1994-07-02
Abstract
Abstract Cardiac arrhythmias and impaired cardiac function associated with congestive heart failure and shock are decreased or eliminated through administration, either orally or parenterally, of β-hydroxy-γ-trimethylaminobutyric acid or a pharmaceutically acceptable non-toxic salt thereof.
Inventors
- 👤 Stephen L. DeFelice
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/205
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
41 words
A method of treating cardiac arrhythmias in humans and animals which comprises administering to a human or an animal in need thereof an amount of β-hydroxy-γ-trimethylaminobutyric acid or a pharmaceutically acceptable non-toxic salt thereof sufficient to decrease or eliminate the arrhythmia.
Claim 2
Independent Claim
41 words
A method of treating cardiac arrhythmias in humans and animals which comprises administering to a human or an animal in need thereof an amount of β-hydroxy-γ-trimethylaminobutyric acid or a pharmaceutically acceptable non-toxic salt thereof sufficient to decrease or eliminate the arrhythmia.
Claim 3
Dependent Claim
16 words
A method according to claim 1 wherein β-hydroxy-γ -trimethylaminobutyric acid or the hydrochloride salt is administered.
Claim 4
Dependent Claim
19 words
A method according to claim 2 wherein the hydrochloride salt of β-hydroxy-γ-trimethylaminobutyric acid is administered in solution by injection.
Claim 5
Dependent Claim
11 words
A method according to claim 1 wherein the administration is parenteral.
Claim 6
Dependent Claim
11 words
A method according to claim 1 wherein the administration is intravenously.
Claim 7
Independent Claim
48 words
A method of improving myocardial contractility and systolic rhythm in congestive heart failure and shock for a human in need thereof which comprises parenterally administering to said human an amount of β-hydroxy-γ-trimethylaminobutyric acid or a pharmaceutically acceptable non-toxic salt thereof sufficient to improve myocardial contractility and systolic rhythm.
Claim 8
Independent Claim
48 words
A method of improving myocardial contractility and systolic rhythm in congestive heart failure and shock for a human in need thereof which comprises parenterally administering to said human an amount of β-hydroxy-γ-trimethylaminobutyric acid or a pharmaceutically acceptable non-toxic salt thereof sufficient to improve myocardial contractility and systolic rhythm.
Claim 9
Independent Claim
48 words
A method of improving myocardial contractility and systolic rhythm in congestive heart failure and shock for a human in need thereof which comprises intravenously administering to said human an amount of β-hydroxy-γ-trimethylaminobutyric acid or a pharmaceutically acceptable non-toxic salt thereof sufficient to improve myocardial contractility and systolic rhythm.
Claim 10
Independent Claim
48 words
A method of improving myocardial contractility and systolic rhythm in congestive heart failure and shock for a human in need thereof which comprises intravenously administering to said human an amount of β-hydroxy-γ-trimethylaminobutyric acid or a pharmaceutically acceptable non-toxic salt thereof sufficient to improve myocardial contractility and systolic rhythm.
References Cited (Backward Citations)
US2278123A
Cited
US2761807A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-06 | 1980-01-05 | 1980-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-06 | 1984-01-05 | 1984-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-06 | 1988-01-05 | 1988-07-06 | $7700.00 | Window Closed / Lapsed |