US3963119A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Serum separating apparatus
Assignee: Organon Teknika Corp
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Filing: 1974-09-16
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Granted: 1976-06-15
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Expires: 1994-09-16
Abstract
Abstract The separation of a sample of blood into serum and clot portions is accomplished by means of a sealant consisting essentially of a silicone fluid and silica dispersed therein. The separation is accomplished by inserting a device containing a supply of the sealant into a container holding a sample of the blood, the device being characterized by a nozzle portion which extends into the sample. The container and device are centrifuged so that it separates into serum and clot portions and the sealant, having a specific gravity of at least 1.026, separates the two portions.
Inventors
- 👤 Michel J. Lukacs
- 👤 Ian H. Jacoby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:47
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
250 words
A dispensing device for holding and dispensing a supply of a sealant used as a separator between serum and clot portions of a blood sample obtained during centrifuging of the sample in an open ended container, said device including: a hollow body portion holding a supply of sealant therein; said sealant comprising a supply of thixotropic, water insoluble, substantially non-toxic material consisting essentially of a silicone fluid and an inert filler dispersed therein, said sealant having a specific gravity in the range of 1.026 to 1.092; said hollow body portion including an integrally formed elongated narrow nozzle portion extending therefrom and containing a portion of the sealant material; said nozzle having a free end portion adapted to extend into a container having a blood sample therein, said free end portion having an opening therein through which the sealant is dispensed during centrifuging; said body having an integrally formed annular shoulder extending from the end thereof opposite the free end portion of the nozzle and an annular side wall extending therefrom towards the nozzle, said shoulder being adapted to engage the opened end of the container for supporting the device in said container, with the side wall of the device received within the container for stabilizing the device therein during centrifuging, whereby upon centrifuging of the blood sample in the container with said device mounted therein, said sealant will separate the blood into serum and clot portions and form a separator between said serum and clot portions of the centrifuged sample.
Claim 2
Dependent Claim
250 words
A dispensing device for holding and dispensing a supply of a sealant used as a separator between serum and clot portions of a blood sample obtained during centrifuging of the sample in an open ended container, said device including: a hollow body portion holding a supply of sealant therein; said sealant comprising a supply of thixotropic, water insoluble, substantially non-toxic material consisting essentially of a silicone fluid and an inert filler dispersed therein, said sealant having a specific gravity in the range of 1.026 to 1.092; said hollow body portion including an integrally formed elongated narrow nozzle portion extending therefrom and containing a portion of the sealant material; said nozzle having a free end portion adapted to extend into a container having a blood sample therein, said free end portion having an opening therein through which the sealant is dispensed during centrifuging; said body having an integrally formed annular shoulder extending from the end thereof opposite the free end portion of the nozzle and an annular side wall extending therefrom towards the nozzle, said shoulder being adapted to engage the opened end of the container for supporting the device in said container, with the side wall of the device received within the container for stabilizing the device therein during centrifuging, whereby upon centrifuging of the blood sample in the container with said device mounted therein, said sealant will separate the blood into serum and clot portions and form a separator between said serum and clot portions of the centrifuged sample.
Claim 3
Dependent Claim
30 words
A device as defined in claim 1 wherein the body portion has an open end opposite the nozzle portion and further includes a cover member extending across said open end.
Claim 4
Dependent Claim
40 words
A device as defined in claim 1 wherein said annular side wall of said body portion is stepped longitudinally along its length to define a plurality of annular shoulders for supporting said device in open end containers of different diameters.
Claim 5
Dependent Claim
30 words
A device as defined in claim 1 wherein said nozzle comprises a narrow elongated and slightly tapered hollow tube adapted to extend into the sample of blood in the containers.
Claim 6
Dependent Claim
154 words
A container and sealant dispensing combination for use with a supply of blood to be separated into serum and clot portions by centrifuging, said combination including: a side walled container having opposite open and closed ends; a supply of sealant and a dispensing device therefor inserted into said container through the open end; said sealant comprising a supply of thixotropic water insoluble material, substantially non-toxic and substantially chemically inert with respect to the constituents of the serum portion of the blood sample and comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 and 1.092; and said dispensing device providing means for metering out the sealant during centrifuging whereby said sealant forms a layer between the serum portion and the clot portion and a tight seal against the inner side wall of the container so that the serum portion may be removed from the container.
Claim 7
Dependent Claim
154 words
A container and sealant dispensing combination for use with a supply of blood to be separated into serum and clot portions by centrifuging, said combination including: a side walled container having opposite open and closed ends; a supply of sealant and a dispensing device therefor inserted into said container through the open end; said sealant comprising a supply of thixotropic water insoluble material, substantially non-toxic and substantially chemically inert with respect to the constituents of the serum portion of the blood sample and comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 and 1.092; and said dispensing device providing means for metering out the sealant during centrifuging whereby said sealant forms a layer between the serum portion and the clot portion and a tight seal against the inner side wall of the container so that the serum portion may be removed from the container.
Claim 8
Independent Claim
146 words
A device for use with a supply of blood to be separated into serum and clot portions by centrifuging, said device comprising, in combination, a container for said blood sample having opposed open and closed ends and a peripheral side wall extending therebetween; and a supply of sealant and a dispensing device therefor in said container; said sealant comprising a supply of thixotropic water insoluble, substantially non-toxic material comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 to 1.092 and being substantially chemically inert with respect to the constituents of the serum portion of the blood sample; said dispensing device providing means for distributing the sealant through the blood sample during centrifuging whereby the blood will separte into serum and clot portions and the sealant will form a barrier layer between the serum and clot portions.
Claim 9
Independent Claim
146 words
A device for use with a supply of blood to be separated into serum and clot portions by centrifuging, said device comprising, in combination, a container for said blood sample having opposed open and closed ends and a peripheral side wall extending therebetween; and a supply of sealant and a dispensing device therefor in said container; said sealant comprising a supply of thixotropic water insoluble, substantially non-toxic material comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 to 1.092 and being substantially chemically inert with respect to the constituents of the serum portion of the blood sample; said dispensing device providing means for distributing the sealant through the blood sample during centrifuging whereby the blood will separte into serum and clot portions and the sealant will form a barrier layer between the serum and clot portions.
Claim 10
Dependent Claim
141 words
A container and sealant combination for use with a supply of blood to be separated into serum and clot portions by centrifuging, said combination including: a side walled container having opposite open and closed ends; a supply of sealant inserted into said container through the open end thereof; said sealant comprising a supply of thixotropic water insoluble material, substantially chemically inert with respect to the constituents of the serum portion of the blood sample comprising a silicone fluid and a filler; and said sealant having a specific gravity in the range of about 1.026 to 1.092, whereby during centrifuging said sealant forms a layer between the serum portion and the clot portions of the blood and a tight seal against the inner surface of the side wall of the container so that the serum portion may be removed from the container.
Claim 11
Dependent Claim
141 words
A container and sealant combination for use with a supply of blood to be separated into serum and clot portions by centrifuging, said combination including: a side walled container having opposite open and closed ends; a supply of sealant inserted into said container through the open end thereof; said sealant comprising a supply of thixotropic water insoluble material, substantially chemically inert with respect to the constituents of the serum portion of the blood sample comprising a silicone fluid and a filler; and said sealant having a specific gravity in the range of about 1.026 to 1.092, whereby during centrifuging said sealant forms a layer between the serum portion and the clot portions of the blood and a tight seal against the inner surface of the side wall of the container so that the serum portion may be removed from the container.
Claim 12
Dependent Claim
26 words
The container and sealant combination as defined in claim 7 wherein said thixotropic material consists essentially of a silicone fluid and an inert filler dispersed therein.
Claim 13
Dependent Claim
163 words
A container and sealant combination for use with a supply of blood to be separated into serum and clot portions by centrifugation and adapted to form a substantially complete physical seal between the separated serum and clot portions; said combination comprising: a container having an open end, an opposed closed end, and a side wall extending therebetween for retaining a supply of blood; and a supply of sealant located within said container; said sealant comprising a supply of thixotropic water insoluble material substantially chemically inert with respect to the constituents of the serum portion of the blood sample and comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 to 1.092 whereby in response to centrifugation, said sealant moves to a position in the container intermediate the serum and clot portions of the blood sample to physically separate the same while forming a relatively tight, fixed seal against the inner surface of the container.
Claim 14
Dependent Claim
163 words
A container and sealant combination for use with a supply of blood to be separated into serum and clot portions by centrifugation and adapted to form a substantially complete physical seal between the separated serum and clot portions; said combination comprising: a container having an open end, an opposed closed end, and a side wall extending therebetween for retaining a supply of blood; and a supply of sealant located within said container; said sealant comprising a supply of thixotropic water insoluble material substantially chemically inert with respect to the constituents of the serum portion of the blood sample and comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 to 1.092 whereby in response to centrifugation, said sealant moves to a position in the container intermediate the serum and clot portions of the blood sample to physically separate the same while forming a relatively tight, fixed seal against the inner surface of the container.
Claim 15
Dependent Claim
150 words
A container and sealant combination containing a supply of blood separated by centrifugation into serum and clot portions of differing specific gravities comprising: a side walled container having opposite open and closed end portions containing a blood sample centrifugally separated into serum and clot portions; and a layer of sealant in said container between said centrifugally separated serum and clot portions forming a relatively tight, fixed seal against the inner surface of the side wall of the container while separating said serum and clot portions; said sealant comprising a supply of thixotropic water insoluble material substantially chemically inert with respect to the constituents of the serum portion of the blood and comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 to 1.092 whereby said layer of sealant is positioned between the serum and clot portions of the blood during centrifuging.
Claim 16
Dependent Claim
150 words
A container and sealant combination containing a supply of blood separated by centrifugation into serum and clot portions of differing specific gravities comprising: a side walled container having opposite open and closed end portions containing a blood sample centrifugally separated into serum and clot portions; and a layer of sealant in said container between said centrifugally separated serum and clot portions forming a relatively tight, fixed seal against the inner surface of the side wall of the container while separating said serum and clot portions; said sealant comprising a supply of thixotropic water insoluble material substantially chemically inert with respect to the constituents of the serum portion of the blood and comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 to 1.092 whereby said layer of sealant is positioned between the serum and clot portions of the blood during centrifuging.
Claim 17
Dependent Claim
106 words
A seal for physically separating the serum and clot portions of a blood sample in a container; said seal comprising a layer of thixotropic water insoluble material substantially chemically inert with respect to the constituents of the serum portion of the blood and comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 to 1.092 and forming a relatively tight, fixed seal against the inner surface of the container at a position between the separated serum and clot portions thereby physically separating the serum and clot portions and enabling the serum portion to be removed by decanting.
Claim 18
Dependent Claim
106 words
A seal for physically separating the serum and clot portions of a blood sample in a container; said seal comprising a layer of thixotropic water insoluble material substantially chemically inert with respect to the constituents of the serum portion of the blood and comprising a silicone fluid and a filler, said sealant having a specific gravity in the range of about 1.026 to 1.092 and forming a relatively tight, fixed seal against the inner surface of the container at a position between the separated serum and clot portions thereby physically separating the serum and clot portions and enabling the serum portion to be removed by decanting.
References Cited (Backward Citations)
US3852194A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-15 | 1979-12-15 | 1980-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-15 | 1983-12-15 | 1984-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-15 | 1987-12-15 | 1988-06-15 | $7700.00 | Window Closed / Lapsed |