US3946732A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Two-chamber mixing syringe
Assignee: Ampoules Inc
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Filing: 1974-07-18
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Granted: 1976-03-30
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Expires: 1994-07-18
Abstract
Abstract Two-chamber syringes for mixing a powdered medicament with a diluent and then injecting the mixed ingredients into a patient are disclosed, together with a technique for assembling those syringes. According to one aspect of the invention, the syringe includes a vial formed with a single glass cylinder closed at one end by a plunger and at its other end by a pierceable diaphragm. An intermediate pierceable diaphragm divides the cylinder into upper and lower chambers, and is locked against axial movement relative to the cylinder. A powdered medicament is provided in the upper chamber and a diluent is provided in the lower chamber. The ingredients are mixed by inserting the vial into a cup-shaped holder having a hollow, pointed needle extending from the base of the holder. Axial pressure on the vial causes the pointed end of the needle to sequentially pierce the end intermediate diaphragms, and to cause the diluent to flow into an opening in the sidewall of the needle, through the needle, and then into the upper chamber from the pointed needle end. The thus-mixed ingredients are dispensed by applying axial pressure to the plunger, or by drawing metered amounts into the medicament pressurizing chamber of a needleless, hypojet injector.
Inventors
- 👤 Alfred A. Hurscham
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:02
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/14; A61J1/20; A61J1/2093; A61M; A61M5/00; A61M5/178; A61M5/24; A61M5/2448; A61J1/2003; A61J1/2006; A61J1/201; A61J1/2013; A61M5/31; A61M2005/3103; A61M2005/3107; A61M2005/3109; A61M5/1782; A61M5/2455; A61M5/2459; A61M5/30; A61M5/3145; A61M5/315; A61M5/31501; A61M5/31505; A61M5/32; A61M5/3202
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
238 words
A two-chamber mixing syringe comprising: a. vial means; b. a plunger slidable within and closing one end of the vial means; c. an end diaphragm closing the other end of the vial means; d. a stationary intermediate diaphragm within said vial means separating the interior of the vial means into first and second chambers respectively defined by said plunger and intermediate diaphragm and by said intermediate diaphragm and said end diaphragm; said vial means and intermediate diaphragm having coacting parts that comprise means for locking the intermediate diaphragm against axial movement towards said plunger during a mixing operation and during a dispensing operation; said coacting parts comprising radially extending interengaging and interfering surfaces on said vial means and said intermediate diaphragm; e. a cup-shaped holder having a cylindrical bore closed at one end and receiving said other end of said vial means with said other end of said vial means spaced from said closed end of said bore; and f. hollow needle means having a pointed end within the space between said other end of said vial means and said closed end of said bore, whereby an ingredient in said first chamber may be mixed with an ingredient in said second chamber by applying axial pressure to said vial means so that said needle sequentially pierces said end diaphragm and said intermediate diaphragm and whereby said ingredients may be dispersed by advancing said plunger toward said intermediate diaphragm.
Claim 2
Dependent Claim
238 words
A two-chamber mixing syringe comprising: a. vial means; b. a plunger slidable within and closing one end of the vial means; c. an end diaphragm closing the other end of the vial means; d. a stationary intermediate diaphragm within said vial means separating the interior of the vial means into first and second chambers respectively defined by said plunger and intermediate diaphragm and by said intermediate diaphragm and said end diaphragm; said vial means and intermediate diaphragm having coacting parts that comprise means for locking the intermediate diaphragm against axial movement towards said plunger during a mixing operation and during a dispensing operation; said coacting parts comprising radially extending interengaging and interfering surfaces on said vial means and said intermediate diaphragm; e. a cup-shaped holder having a cylindrical bore closed at one end and receiving said other end of said vial means with said other end of said vial means spaced from said closed end of said bore; and f. hollow needle means having a pointed end within the space between said other end of said vial means and said closed end of said bore, whereby an ingredient in said first chamber may be mixed with an ingredient in said second chamber by applying axial pressure to said vial means so that said needle sequentially pierces said end diaphragm and said intermediate diaphragm and whereby said ingredients may be dispersed by advancing said plunger toward said intermediate diaphragm.
Claim 3
Dependent Claim
21 words
A two-chamber mixing syringe according to claim 1 wherein said coacting parts lock the intermediate diaphragm against movement in both directions.
Claim 4
Dependent Claim
35 words
A two-chamber mixing syringe according to claim 2 wherein said needle means includes another pointed end projecting from said holder in axial alignment with the pointed end within said space and in fluid communication therewith.
Claim 5
Dependent Claim
21 words
A two-chamber mixing syringe according to claim 2 wherein said needle means has an opening therein spaced from said pointed end.
Claim 6
Dependent Claim
21 words
A two-chamber mixing syringe according to claim 4 wherein said intermediate diaphragm and said end diaphragm have axially aligned pierceable portions.
Claim 7
Dependent Claim
28 words
A two-chamber mixing syringe according to claim 5 wherein the axial longitudinal extent of said needle opening exceeds the thickness of the pierceable portion of said intermediate diaphragm.
Claim 8
Dependent Claim
28 words
A two-chamber mixing syringe according to claim 6 wherein the needle means within said space projects from end abutment means extending from the closed end of said bore.
Claim 9
Dependent Claim
25 words
A two-chamber mixing syringe according to claim 7 wherein the abutment means is adapted to be received within said other end of said vial means.
Claim 10
Dependent Claim
31 words
A two-chamber mixing syringe according to claim 7 wherein the distance between the abutment means and the opening in the needle does not substantially exceed the thickness of said end diaphragm.
Claim 11
Dependent Claim
45 words
A two-chamber mixing syringe according to claim 7 wherein the distance between said abutment means and the pointed end of the needle exceeds the combined axial extents of the thickness of said end diaphragm, the second chamber and the pierceable portion of said intermediate diaphragm.
Claim 12
Dependent Claim
26 words
A two-chamber mixing syringe according to claim 2 wherein portions of the intermediate and end diaphragms defining said second chamber are complementary surfaces for mating engagement.
Claim 13
Dependent Claim
27 words
A two-chamber mixing syringe according to claim 2 wherein portions of said plunger and said intermediate diaphragm defining said first chamber are complementary surfaces for mating engagement.
Claim 14
Dependent Claim
21 words
A two-chamber mixing syringe according to claim 4 wherein said opening is covered by a flexible sleeve which surrounds said needle.
Claim 15
Dependent Claim
32 words
A two-chamber mixing syringe according to claim 2 wherein said coacting parts include an inwardly extending circumferential rib in the vial means which cooperate with a circumferential recess in said intermediate diaphragm.
Claim 16
Dependent Claim
41 words
A two-chamber mixing syringe according to claim 14 wherein a circumferential groove in the exterior sidewall of the vial means provides said inwardly extending circumferential rib and wherein a wire clip having prongs directed toward said one end encircles said groove.
Claim 17
Dependent Claim
64 words
A two-chamber mixing syringe according to claim 2 wherein energy storing means is provided between said end diaphragm and the closed end of said bore and is adapted to apply increasing amounts of pressure to said end diaphragm as said axial pressure is applied, whereby said energy storing means drives said end diaphragm toward said intermediate diaphragm when said needle pierces said intermediate diaphragm.
Claim 18
Dependent Claim
16 words
A two-chamber mixing syringe according to claim 16 wherein said energy storing means comprises a spring.
Claim 19
Dependent Claim
32 words
A two-chamber mixing syringe according to claim 16 wherein said needle has a beveled edge, the axial entent of which exceeds the axial extent of a pierceable portion of said intermediate diaphragm.
Claim 20
Dependent Claim
21 words
A two-chamber mixing syringe according to claim 3 wherein filter means is provided between the pointed ends of said needle means.
Claim 21
Dependent Claim
45 words
A two-chamber mixing syringe according to claim 1 wherein there is provided means between said vial and said cup-shaped holder to prevent withdrawal of said vial from said holder prior to and during axial movement of said vial and cup-shaped holder relative to each other.
Claim 22
Dependent Claim
30 words
A two-chamber mixing syringe according to claim 20 wherein said means for preventing said axial movement is located in a circumferential groove in the exterior sidewall of the vial means.
Claim 23
Dependent Claim
20 words
A two-chamber mixing syringe according to claim 9 wherein the needle has a beveled edge which constitutes said window opening.
Claim 24
Dependent Claim
226 words
A two-chamber mixing syringe comprising: a. a glass cylinder; b. a plunger slidable within and closing one end of the cylinder; c. an end diaphragm closing the other end of the cylinder; d. a stationary intermediate diaphragm within said cylinder separating the interior of the cylinder into first and second chambers respectively defined by said plunger and intermediate diaphragm and by said intermediate diaphragm and end diaphragm; said cylinder and intermediate diaphragm having coacting parts that comprise means for locking the intermediate diaphragm against axial movement toward said plunger during a mixing and during a dispensing operation; said coacting parts comprising radially extending interengaging and interfering surfaces on said vial means and said intermediate diaphragm; e. a cup-shaped holder having a cylindrical bore closed at one end and receiving said other end of said cylinder with said other end of said cylinder spaced from said closed end of said bore; and f. a hollow pointed needle within the space between said other end of said cylinder and said closed end of said bore, whereby an ingredient in said first chamber may be mixed with an ingredient in said second chamber by applying axial pressure to said vial means so that said needle sequentially pierces said end diaphragm and said intermediate diaphragm and whereby said ingredients may be dispersed by advancing said plunger toward said intermediate diaphragm.
Claim 25
Dependent Claim
226 words
A two-chamber mixing syringe comprising: a. a glass cylinder; b. a plunger slidable within and closing one end of the cylinder; c. an end diaphragm closing the other end of the cylinder; d. a stationary intermediate diaphragm within said cylinder separating the interior of the cylinder into first and second chambers respectively defined by said plunger and intermediate diaphragm and by said intermediate diaphragm and end diaphragm; said cylinder and intermediate diaphragm having coacting parts that comprise means for locking the intermediate diaphragm against axial movement toward said plunger during a mixing and during a dispensing operation; said coacting parts comprising radially extending interengaging and interfering surfaces on said vial means and said intermediate diaphragm; e. a cup-shaped holder having a cylindrical bore closed at one end and receiving said other end of said cylinder with said other end of said cylinder spaced from said closed end of said bore; and f. a hollow pointed needle within the space between said other end of said cylinder and said closed end of said bore, whereby an ingredient in said first chamber may be mixed with an ingredient in said second chamber by applying axial pressure to said vial means so that said needle sequentially pierces said end diaphragm and said intermediate diaphragm and whereby said ingredients may be dispersed by advancing said plunger toward said intermediate diaphragm.
Claim 26
Dependent Claim
25 words
A two-chamber mixing syringe according to claim 23 wherein said coacting parts lock said intermediate diaphragm against axial movement toward said plunger and intermediate diaphragm.
Claim 27
Dependent Claim
31 words
A two-chamber mixing syringe according to claim 24 wherein said coacting parts comprise an inwardly extending circumferential rib in the cylinder which cooperates with a circumferential recess in said intermediate diaphragm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-30 | 1979-09-29 | 1980-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-30 | 1983-09-29 | 1984-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-30 | 1987-09-29 | 1988-03-30 | $7700.00 | Window Closed / Lapsed |