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US3935303A Expired / Lapsed US ⏱️ 0.0 years remaining

Base for ophthalmological medicinal preparations and on ophthalmological medicinal film

Assignee: Individual
•
Filing: 1972-11-01
•
Granted: 1976-01-27
•
Expires: 1992-11-01
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Abstract

Abstract A base for ophthalmological medicinal preparations consists of a homopolymer of an amide of acrylic acid having a molecular weight from 30,000 to 1,000,000, and/or a copolymer of an amide of acrylic acid with unsaturated compounds, the molecular weight of the copolymer being from 20,000 to 500,000, and containing from 10 to 90 percent acrylamide links. The ophthalmological medicinal film is an oblong plate, 6-9 mm long, 3 - 5 mm wide and 0.2 - 0.6 mm thick, of the hompolymer and/or copolymer and an active medicinal ingredient, viz., 3-ethyl-4(1-methyl-5-imidazolyl)-tetrahydrofuran-2-one or atropine, or 3-methoxy-6-sulfanilam idopyridazine, or β-dimethylamino-ethyl-p-butylaminobenzoate, or neamine, or 5-iodo-2-desoxyuridine. The ophthalmological medicinal film is used for treatment of glaucoma of various forms, thrombosis of the central vein of the retina, atrophy of the optic nerve, for dilating the pupil and paralysis of accommodation in treatment of keratitis, iritis, iridocyclitis, ulcers of the cornea, trachoma, herpetic keratitis, uveitis and adenoviral infections, in extraction of foreign objects from the eye, and in various interventions in the organ of vision.

Inventors

  • 👤 Gennady Lvovich Khromov
  • 👤 Anatoly Borisovich Davydov
  • 👤 Jury Fedorovich Maichuk
  • 👤 Inna Fedorovna Tischina

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 18:04
CPC Classifications
G; G02; G02B; G02B1/00; G02B1/04; G02B1/041; G02B1/043; A; A61; A61K; A61K31/00; A61K31/74; A61K31/785; A61K31/787; A61K31/79; A61K9/00; A61K9/0012; A61K9/0048; A61K9/0051; C; C08; C08L; C08L33/00; C08L33/24; C08L33/26

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 85 words
An ophthalmological medicinal film which is an oblong plate, 6 - 9 mm long, 3 - 5 mm wide, and 0.2 - 0.6 mm thick consisting of a biologically soluble, assimilable copolymer of acrylamide, N-vinylpyrrolidone and butyl acrylate having a molecular weight from 20,000 to 500,000 and containing 10 to 90 per cent acrylamide links and an ophthalmological medicinal agent, selected from the group consisting of 3-ethyl-4(1-methyl-5-imidazolyl)- tetrahydrofuran-2-one, atropine, 3-methoxy-6-sulfanilamidopyridazine, β -dimethylaminoethyl-p-butylaminobenzoate, neamine and 5-iodo-2-desoxyuridine, said film characterized by prolonged medicinal action in the eye.
Claim 2
Dependent Claim 85 words
An ophthalmological medicinal film which is an oblong plate, 6 - 9 mm long, 3 - 5 mm wide, and 0.2 - 0.6 mm thick consisting of a biologically soluble, assimilable copolymer of acrylamide, N-vinylpyrrolidone and butyl acrylate having a molecular weight from 20,000 to 500,000 and containing 10 to 90 per cent acrylamide links and an ophthalmological medicinal agent, selected from the group consisting of 3-ethyl-4(1-methyl-5-imidazolyl)- tetrahydrofuran-2-one, atropine, 3-methoxy-6-sulfanilamidopyridazine, β -dimethylaminoethyl-p-butylaminobenzoate, neamine and 5-iodo-2-desoxyuridine, said film characterized by prolonged medicinal action in the eye.
Claim 3
Dependent Claim 27 words
A film according to claim 1, wherein the copolymer contains 42% acrylamide, and the ratio of acrylamide, N-vinylpyrrolidone and butyl acrylate is 0.4 : 0.3 : 0.3.
Claim 4
Dependent Claim 91 words
In the treatment of eye disorders by the application to the eye of a film containing an active ophthalmological medicinal agent, the improvement consisting of the step of applying in the anterior part of the conjunctival cavity of the eye a film being dissoluble in lacrimal fluid, having a prolonged medicinal action in the eye, and consisting of biologically soluble, assimilable copolymer of acrylamide, N-vinylpyrrolidone and butyl acrylate having a molecular weight from 20,000 to 500,000 and containing 10 to 90 per cent acrylamide links and an active ophthalmological medicinal agent.
Claim 5
Dependent Claim 91 words
In the treatment of eye disorders by the application to the eye of a film containing an active ophthalmological medicinal agent, the improvement consisting of the step of applying in the anterior part of the conjunctival cavity of the eye a film being dissoluble in lacrimal fluid, having a prolonged medicinal action in the eye, and consisting of biologically soluble, assimilable copolymer of acrylamide, N-vinylpyrrolidone and butyl acrylate having a molecular weight from 20,000 to 500,000 and containing 10 to 90 per cent acrylamide links and an active ophthalmological medicinal agent.
Claim 6
Dependent Claim 24 words
The improvement of claim 3, wherein the medicinal agent is selected from the group consisting of 3-ethyl-4(1 -methyl-5-imidazolyl)-tetrahydrofuran-2-one, atropine, 3-methoxy-6-sulfanilamidropyridazine, β-dimethylaminoethyl-p-butylaminobenzoate, neamine and 52-desoxyyuridine.
Claim 7
Dependent Claim 26 words
The improvement of claim 3, wherein the copolymer contains 42% acrylamide and the ratio of acrylamide, N-vinyl-pyrrolidone and butyl acrylate is 0.4 : 0.3 : 0.3.

References Cited (Backward Citations)

US3025219A Cited
US3697643A Cited
US3576760A Cited
US3577518A Cited
US3577516A Cited
US3775537A Cited
US3641237A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1979-01-26 1979-07-28 1980-01-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1983-01-26 1983-07-28 1984-01-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1987-01-26 1987-07-28 1988-01-27 $7700.00 Window Closed / Lapsed

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