Biologically active material

Claim 1

A pharmaceutical composition useful for treating viral infections caused by any one or more of a wide variety of DNA and RNA viruses in suseptible mammals which comprises an effective serum-interferon producing ribonuclease-stable amount of an antiviral complex which is a principally ionic complex soluble in 0.15 M aqueous sodium chloride solution in which the cations are organic polymer polycations having a plurality of quaternary nitrogen sites located at intervals along the polymer chains, said polycations having the formula ##EQU6## wherein each of a and b, independent of the other, is an integer of from 2 to 6 and X is a number which is such that the average molecular weight of the polycation divided by the equivalent weight which is the molecular weight of the polycation divided by the value (2X + 2) is not greater than 98, and the anions are one of: (a) double-stranded ribonucleic acid polyanions, said double-stranded ribonucleic acid being of natural origin, or (b) polyanions of a double-stranded ribonucleic acid of natural origin which has been subject to chemical or enzymatic reaction which alters one or more of the primary, secondary, and tertiary structure, provided that the resultant ribonucleic acid retains a substantial degree of base pairing between complementary strands, said antiviral complex having more than 60% of the anionic sites on the double-stranded ribonucleic acid anions neutralized by the quaternary cationic sites on the quaternary polymer, in combination with a pharmaceutically acceptable nontoxic liquid injectable or topical carrier.