US3926737A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for control of biochemical processes
Assignee: New Brunswick Scientific Co Inc
•
Filing: 1973-09-24
•
Granted: 1975-12-16
•
Expires: 1993-09-24
Abstract
Abstract Biochemical processes are controlled by detecting a plurality of selected controllable variables and dependent variables and actuating controllers for maintaining said controllable variables within predetermined tolerance values in response to said detected controllable variable values and a time profile of each of said tolerance limits. On-line, real-time computer calculations are performed to determine the status of said process from said detected dependent and controllable variable values. Said controllers may be manually or automatically actuated in response to said calculated status, or the timeprofiles of the tolerance values may be automatically or manually adjusted in response to said calculated status.
Inventors
- 👤 John D Wilson
- 👤 Laszlo K Nyiri
- 👤 Arthur E Humphrey
- 👤 Iii Clyde S Harmes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:56
CPC Classifications
C; C12; C12M; C12M41/00; C12M41/48; B; B01; B01J; B01J19/00; B01J19/0006; B01J19/18; C12M41/26; C12M41/30; C12M41/32; G; G06; G06F; G06F15/00; G06F15/08; G06F15/14; B01J2219/00; B01J2219/00049; B01J2219/00051; B01J2219/00054; B01J2219/00056; B01J2219/00058; B01J2219/00162; B01J2219/00164; B01J2219/00177; B01J2219/00189
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
113 words
A METHOD FOR ANALYSIS AND CONTROL OF BIOCHEMICAL PROCESSES COMPRISING DETECTING THE VALUES OF SELECTED CONTROLLABLE AND DEPENDENT VARIABLES AT AT LEAST PERODIC INTERVALS IN SAID BIOCHEMICAL PROCESS; CALCULATING BY MEANS OF A COMPUTER AT LEAST ONE FURTHER, NOT DIRECTLY MEASURABLE DEPENDENT VARIABLE ON A REAL-TIME, ON LINE BASIC FROM SAID PLURALITY OF SELECTED CONTROLLABLE AND DEPENDENT VARIABLES, SAID FURTHER, NOT DIRECTLY MEASURABLE DEPENDENT VARIABLE BEING REPRESENTATIVE OF THE STAGE OF THE BIOCHEMICAL PROCESS; AND INTERACTIVELY REGULATING THE VALUES OF SAID CONTROLLABLE VARIABLES IN RESPONSE TO SAID CALCULATED VALUES OF SAID FURTHER DEPENDENT VARIABLE TO BRING SAID FURTER DEPENDENT VARIABLE TO PREDETERMINED LEVELS TO CREATE THE DESIRED ENVIRONMENTAL CONDITIONS FOR THE BIOCHEMICAL PROCESS.
Claim 2
Independent Claim
113 words
A METHOD FOR ANALYSIS AND CONTROL OF BIOCHEMICAL PROCESSES COMPRISING DETECTING THE VALUES OF SELECTED CONTROLLABLE AND DEPENDENT VARIABLES AT AT LEAST PERODIC INTERVALS IN SAID BIOCHEMICAL PROCESS; CALCULATING BY MEANS OF A COMPUTER AT LEAST ONE FURTHER, NOT DIRECTLY MEASURABLE DEPENDENT VARIABLE ON A REAL-TIME, ON LINE BASIC FROM SAID PLURALITY OF SELECTED CONTROLLABLE AND DEPENDENT VARIABLES, SAID FURTHER, NOT DIRECTLY MEASURABLE DEPENDENT VARIABLE BEING REPRESENTATIVE OF THE STAGE OF THE BIOCHEMICAL PROCESS; AND INTERACTIVELY REGULATING THE VALUES OF SAID CONTROLLABLE VARIABLES IN RESPONSE TO SAID CALCULATED VALUES OF SAID FURTHER DEPENDENT VARIABLE TO BRING SAID FURTER DEPENDENT VARIABLE TO PREDETERMINED LEVELS TO CREATE THE DESIRED ENVIRONMENTAL CONDITIONS FOR THE BIOCHEMICAL PROCESS.
Claim 3
Dependent Claim
24 words
The method as recited in claim 1, wherein said biochemical process is accomplished through the function of one or more cellbound and/or cellfree enzymes.
Claim 4
Dependent Claim
14 words
The method as recited in claim 1, wherein said process is a fermentation process.
Claim 5
Dependent Claim
29 words
The method as recited in claim 1, wherein said controllable varibles include temperature, pH, concentration and ratio of substrates and precursors, dissolved oxygen, and dissolved carbon dioxide (HCO3 ).
Claim 6
Dependent Claim
22 words
The method as recited in claim 1, wherein said further dependent variables are representative of the rheological conditions of the culture liquid.
Claim 7
Dependent Claim
22 words
The method as recited in claim 1, wherein said further dependent variables are representative of the physiological status of the biochemical process.
Claim 8
Dependent Claim
21 words
The method as recited in claim 1, wherein said further dependent variables are representative of the biochemical status of the process.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-15 | 1979-06-16 | 1979-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-15 | 1983-06-16 | 1983-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-15 | 1987-06-16 | 1987-12-16 | $7700.00 | Window Closed / Lapsed |