Topical agent for alleviation of full thickness burns in mammals

Abstract

Abstract A method embodying a new use for the known natural lipid ethyl linoleate (ethyl-cis, cis (9, 12)-octadecadienoate). This compound in the presence of a related stabilizer such as ethyl linolenate (ethyl-cis, cis, cis (9, 12, 15)-octadecatrienoate) or an anti-oxidant such as propyl gallate, riboflavin, and ascorbic acid has previously been utilized in burn therapy to diminish water loss through the skin, but a critical limitation of use only after 12 hours post-burn was noted, it being thought that the time lag was probably due to time consumed in conjugation with protein in full thickness burns on the skin or full hydration of the full thickness burns. The present use of ethyl linoleate, both in animals and in human therapy, utilizes the compound preferably neat and uses the characteristic that burn relief from full thickness burns or third degree burns may be achieved immediately post-burn. The compound is used in approximately the same effective quantities, e.g., 0.2-0.8 mg/cm2 of burned area with an optimum value of 0.5 mg/cm2 of burned area, and in humans it has been found advisable to repeat the dosage per diem until full therapeutic effect is realized.

Inventors

• 👤 Iii Carl Jelenko

Bibliographic Details