US3916898A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Administration of medicaments and the like
Assignee: GD Searle LLC
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Filing: 1970-07-10
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Granted: 1975-11-04
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Expires: 1990-07-10
Abstract
Abstract The method of controlling estrus and ovulation, and thus fertility in domestic animals by introducing into the vagina, and later removing, a sponge impregnated with a progestational compound. A sponge, for intravaginal administration in animals, impregnated with a progestational compound.
Inventors
- 👤 Terrence J Robinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:55
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/57; A61K9/00; A61K9/0012; A61K9/0034; A61K9/0036; A61K9/14; A61M; A61M31/00; A61M31/002; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/76
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
55 words
The method of controlling fertility of domestic farm animals, which comprises the administration of a removable sponge impregnated with a progestational steroid, permitting the sponge to remain in the animal to continuously release the steroid and inhibit ovulation, followed by removal of the sponge prior to the time insemination of the animal is to occur.
Claim 2
Independent Claim
55 words
The method of controlling fertility of domestic farm animals, which comprises the administration of a removable sponge impregnated with a progestational steroid, permitting the sponge to remain in the animal to continuously release the steroid and inhibit ovulation, followed by removal of the sponge prior to the time insemination of the animal is to occur.
Claim 3
Dependent Claim
27 words
The method of claim 1, in which the sponge is administered intravaginally and the amount of steroid is at least a minimum effective, 16 day total dose.
Claim 4
Dependent Claim
19 words
The method of claim 2, in which the sponge is removed at about 16 to 25 days after insertion.
Claim 5
Dependent Claim
53 words
The method of claim 2, in which the progestational steroid is selected from the group consisting of progesterone, 17 Alpha -acetoxy-9 Alpha -fluoro-11 Beta -hydroxypregn-4-ene-3,20-dione, 9 Alpha -fluoro-11 Beta -hydroxypregn-4-ene-3,20-dione, 9 Alpha -chloro-11 Beta -hydroxy-pregn-4-ene-3,20-dione, 17 Beta -hydroxy-17 Alpha -methallylestr-4-en-3-one, 17 Alpha -acetoxy-6 Alpha -methylpregn-4-ene-3,20-dione, 17 Alpha -acetoxy-6-chloropregna-4, 6-diene-3,20-dione, and 17 Alpha -acetoxy-6-methylpregna-4,6-diene-3,20-dione.
Claim 6
Dependent Claim
38 words
The method of claim 4, in which the sponge is impregnated with at least 5 milligrams of 17 Alpha -acetoxy-9 Alpha -fluoro-11 Beta -hydroxypregn-4-ene-3,20-dione per 16 day period in which the sponge is to remain in the vagina.
Claim 7
Dependent Claim
23 words
The method of claim 5, in which the sponge is impregnated with about 10 to 40 milligrams of 17 Alpha -acetoxy-6 Alpha -methylpregn-4-ene-3,20-dione.
Claim 8
Dependent Claim
36 words
The method of claim 4, in which the sponge is impregnated with at least 5 milligrams of 17 Alpha -acetoxy-6 Alpha -methylpregn-4-ene-3,20-dione per 16 day period in which the sponge is to remain in the vagina.
Claim 9
Dependent Claim
30 words
A removable sponge suitable for intravaginal administration in domestic animals and impregnated with a progestational compound in an amount of at least a minimum effective, sixteen day total day dose.
Claim 10
Dependent Claim
30 words
A removable sponge suitable for intravaginal administration in domestic animals and impregnated with a progestational compound in an amount of at least a minimum effective, sixteen day total day dose.
Claim 11
Dependent Claim
17 words
The sponge of claim 8, in which the progestational compound is an ovulation and estrus synchronizing steroid.
Claim 12
Dependent Claim
52 words
The sponge of claim 9, in which the steroid is selected from the group consisting of progesterone, 17 Alpha -acetoxy-9 Alpha -fluoro-11 Beta -hydroxypregn-4-ene-3,20-dione, 9 Alpha -fluoro-11 Beta -hydroxypregn-4-ene-3,20-dione, 9 Alpha -chloro-11 Beta -hydroxypregn-4-ene-3,20-dione, 17 Beta -hydroxy-17 Alpha -methallylestr-4-en-3-one, 17 Alpha -acetoxy-6 Alpha -methylpregn-4-ene-3,20-dione, 17 Alpha -acetoxy-6-chloropregna-4,6-diene-3, 20-dione, and 17 Alpha -acetoxy-6-methylpregna-4,6-diene-3,20-dione.
Claim 13
Dependent Claim
13 words
The sponge of claim 10, impregnated with at least 350 milligrams of progesterone.
Claim 14
Dependent Claim
19 words
The sponge of claim 10, impregnated with at least 5 milligrams of 17 Alpha -acetoxy-9 Alpha -fluoro-11 Beta -hydroxypregn-4-ene-3,20-dione.
Claim 15
Dependent Claim
21 words
The sponge of claim 12, impregnated with from about 10 to 40 milligrams of 17 Alpha -acetoxy-9 Alpha -fluoro-11 Beta -hydroxypregn-4-ene-3,20-dione.
Claim 16
Dependent Claim
17 words
The sponge of claim 10, impregnated with at least 5 milligrams of 17 Alpha -acetoxy-6 Alpha -methylpregn-4-ene-3,20-dione.
Claim 17
Dependent Claim
17 words
The sponge of claim 10, impregnated with at least 10 milligrams of 17 Beta -hydroxy-17 Alpha -methallylestr-4-en-3-one.
Claim 18
Dependent Claim
21 words
The sponge of claim 10, suitable for intravaginal administration in the cow and impregnated with at least 1000 milligrams of progesterone.
Claim 19
Dependent Claim
27 words
The sponge of claim 10, suitable for intravaginal administration in the cow and impregnated with at least 30 milligrams of 17 Alpha -acetoxy-9 Alpha -fluoro-11 Beta -hydroxypregn-4-ene-3,20-dione.
Claim 20
Dependent Claim
95 words
An estrus block and enhancement technique which comprises: i. surgically inserting into a female domestic animal an implant of a medicament whose pharmacologic action blocks occurrence of estrus. ii. permitting the implant to remain in the animal and continuously release medicament for about 16-18 days, said implant being adapted to release medicament continuously for at least 18 days. iii. surgically removing said implant at the expiration of said 16-18 day waiting period, thereby halting medication, whereby a rebound phenomenon enhances estrus and onset of estrus occurs in from 2-4 days following removal of said implant.
Claim 21
Dependent Claim
95 words
An estrus block and enhancement technique which comprises: i. surgically inserting into a female domestic animal an implant of a medicament whose pharmacologic action blocks occurrence of estrus. ii. permitting the implant to remain in the animal and continuously release medicament for about 16-18 days, said implant being adapted to release medicament continuously for at least 18 days. iii. surgically removing said implant at the expiration of said 16-18 day waiting period, thereby halting medication, whereby a rebound phenomenon enhances estrus and onset of estrus occurs in from 2-4 days following removal of said implant.
Claim 22
Dependent Claim
33 words
The method of claim 18, wherein multiple numbers of female animals are implanted at one time and implants are removed at one time and synchronized estrus in the so treated group is attained.
Claim 23
Dependent Claim
18 words
The method of claim 18, wherein the female animal is artificially inseminated daily during said 2-4 day period.
References Cited (Backward Citations)
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US2895875A
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US2987445A
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US2943979A
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US3262450A
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US3279996A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-03 | 1979-05-05 | 1979-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-03 | 1983-05-05 | 1983-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-03 | 1987-05-05 | 1987-11-04 | $7700.00 | Window Closed / Lapsed |