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US3916176A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for classifying supposedly cancerous cytologic preparations and apparatus for identifying supposedly cancerous cytologic preparations effecting this method

Assignee: Individual
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Filing: 1973-08-30
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Granted: 1975-10-28
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Expires: 1993-08-30
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Abstract

Abstract A method and apparatus for classification of supposedly cancerous cytologic preparations with reference to images of cells of these preparations, whereby a preset number n of optical density levels is discriminated in the image of cells of said preparations, the geometrical parameters of cells are measured at each preset level of optical density, and then, on the basis of all the measured geometrical parameters of said cells, the position of each cell is established in the n-dimensional space of these geometrical parameters, each cell being classified as normal or atypical, depending upon its position relative to a hypersurface preset for a given localization.

Inventors

  • 👤 Imant Karlovich Alien
  • 👤 Grigory Petrovich Krupnikov
  • 👤 Arkady Yakovlevich Khesin
  • 👤 David Moiseevich Bakhmutsky
  • 👤 Velta Mikelevna Bramberga
  • 👤 Mark Naumovich Libenson
  • 👤 Jury Olegovich Popov
  • 👤 Vladislav Alexandrov Sitovenko
  • 👤 Lev Isaakovich Stolov
  • 👤 Boris Albertovich Yanson

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 15:12
CPC Classifications
G; G06; G06T; G06T7/00; G06T7/0002; G06T7/0012; G06V; G06V20/00; G06V20/60; G06V20/69; G06T2207/00; G06T2207/30; G06T2207/30004; G06T2207/30024

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 517 words
An apparatus for identifying supposedly cancerous cytologic preparations with reference to an image of cells of these preparaTions, comprising: a means for generating signals carrying information about areas Si of said image of said cell of said cytologic preparation at preset levels i of optical density of said image of that cell and about a serial number of levels, having a first output which provides a signal carrying information about said areas, and a second output which provides a signal carrying information about a serial number of these levels; a unit for classification of said cell as normal or atypical depending upon said areas of said cell measured at the preset levels i of optical density, applied whereto are said signals carrying information about said areas Si of said image of said cell of said cytologic preparation at the preset levels i of optical density of said image of that cell and about a serial number of the levels; a pulse frequency divider of said unit for classification of said cell as normal or atypical, having a first input and a second input and an output; the first and the second inputs of said divider connected to the first and the second outputs of said means for generating said pulses carrying information about said areas Si of said image of said cell of said cytologic preparation at the preset levels i of optical density of said image of that cell and about a serial number of the levels; said divider dividing the area Si of said image of said cell, measured at the preset level i of optical density, by a weight division coefficient ai corresponding to that level; a reversible counter of said unit for classification of said cell as normal or atypical; having a counting input, reversal control inputs and digit outputs; said counting input of said reversible counter connected to said output of said divider; a unit for controlling said reversible counter, also incorporated into said unit for classification of said cell as normal or atypical, whose input is connected to the second output of said means for generating signals carrying information about said areas Si of said image of said cell of said cytologic preparation at the preset levels i of optical density of said image of that cell and about a serial number of the levels; said reversal control inputs of said reversible counter connected to said unit for controlling said reversible counter, so that following the application to the input of that unit of a signal carrying information about a serial number of levels i of optical density of said image of said cell from the second output of said means for generating said signals carrying information about said areas Si of said image of said cell of said cytologic preparation at the preset levels i of optical density of said image of that cell and a serial number of levels, said unit for controlling said reversible counter switches, depending upon the serial number of the level of optical density, said reversible counter, which contains the sum of the weighed areas
Claim 2
Independent Claim 517 words
An apparatus for identifying supposedly cancerous cytologic preparations with reference to an image of cells of these preparaTions, comprising: a means for generating signals carrying information about areas Si of said image of said cell of said cytologic preparation at preset levels i of optical density of said image of that cell and about a serial number of levels, having a first output which provides a signal carrying information about said areas, and a second output which provides a signal carrying information about a serial number of these levels; a unit for classification of said cell as normal or atypical depending upon said areas of said cell measured at the preset levels i of optical density, applied whereto are said signals carrying information about said areas Si of said image of said cell of said cytologic preparation at the preset levels i of optical density of said image of that cell and about a serial number of the levels; a pulse frequency divider of said unit for classification of said cell as normal or atypical, having a first input and a second input and an output; the first and the second inputs of said divider connected to the first and the second outputs of said means for generating said pulses carrying information about said areas Si of said image of said cell of said cytologic preparation at the preset levels i of optical density of said image of that cell and about a serial number of the levels; said divider dividing the area Si of said image of said cell, measured at the preset level i of optical density, by a weight division coefficient ai corresponding to that level; a reversible counter of said unit for classification of said cell as normal or atypical; having a counting input, reversal control inputs and digit outputs; said counting input of said reversible counter connected to said output of said divider; a unit for controlling said reversible counter, also incorporated into said unit for classification of said cell as normal or atypical, whose input is connected to the second output of said means for generating signals carrying information about said areas Si of said image of said cell of said cytologic preparation at the preset levels i of optical density of said image of that cell and about a serial number of the levels; said reversal control inputs of said reversible counter connected to said unit for controlling said reversible counter, so that following the application to the input of that unit of a signal carrying information about a serial number of levels i of optical density of said image of said cell from the second output of said means for generating said signals carrying information about said areas Si of said image of said cell of said cytologic preparation at the preset levels i of optical density of said image of that cell and a serial number of levels, said unit for controlling said reversible counter switches, depending upon the serial number of the level of optical density, said reversible counter, which contains the sum of the weighed areas
Claim 3
Dependent Claim 119 words
The apparatus as claimed in claim 1, further comprising a unit for classification of said cytologic preparation as normal or pathological performed in the course of successive classification of cells of said preparation; said unit for classification having a group of inputs connected to the outputs of said first channel of said recording unit to represent the number of atypical cells and a separate input connected to the output of said second channel of said recording unit to represent the total number of classified cells; said unit for classification for comparing the number and the ratio of normal and atypical cells with a boundary value preset for a given localization of cancer to identify said preparation as a whole.
Claim 4
Independent Claim 175 words
A method for the classification of supposedly cancerous cytologic preparations with reference to images of cells of these preparations, based upon converting a video signal obtained in the course of scanning of said images and processing information contained in said video signal representative of optical and geometrical parameters of said images, comprising the following steps: discriminating a portion of said video signal representative of the image of a cell to be classified; detecting the extreme black and white levels of said discriminated video signal; converting said discriminated video signal into n electrical signals each corresponding to one of n preset levels of optical density within the limits of said detected extreme black and white levels; measuring parameters of each of said n electrical signals to provide information representative of optical and geometrical parameters of said image of said cell to be classified; and classifying said cell into a normal cell or an atypical cell depending upon the combination of said measured parameters representative of the optical and geometrical parameters of said image of said cell.
Claim 5
Independent Claim 175 words
A method for the classification of supposedly cancerous cytologic preparations with reference to images of cells of these preparations, based upon converting a video signal obtained in the course of scanning of said images and processing information contained in said video signal representative of optical and geometrical parameters of said images, comprising the following steps: discriminating a portion of said video signal representative of the image of a cell to be classified; detecting the extreme black and white levels of said discriminated video signal; converting said discriminated video signal into n electrical signals each corresponding to one of n preset levels of optical density within the limits of said detected extreme black and white levels; measuring parameters of each of said n electrical signals to provide information representative of optical and geometrical parameters of said image of said cell to be classified; and classifying said cell into a normal cell or an atypical cell depending upon the combination of said measured parameters representative of the optical and geometrical parameters of said image of said cell.
Claim 6
Dependent Claim 22 words
A method as claimed in claim 3, whereby the number of optical density levels of the image of said cell is six.
Claim 7
Dependent Claim 47 words
The method as claimed in claim 3 wherein said images of said cells of said preparation are successively scanned and said cells are successively classified until the number and the ratio of normal and atypical cells reaches a boundary value preset for a given localization of cancer.
Claim 8
Dependent Claim 22 words
A method as claimed in claim 5, whereby the number of optical density levels of the image of said cell is six.

References Cited (Backward Citations)

US3706877A Cited
US3742196A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-10-27 1979-04-28 1979-10-28 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-10-27 1983-04-28 1983-10-28 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-10-27 1987-04-28 1987-10-28 $7700.00 Window Closed / Lapsed

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