Patent WO1992003993A1 successfully refreshed from Google Patents.
US3914174A
Expired / Lapsed
US
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Layer material for the rapid chromatographic identification of fluid substances, method for the preparation thereof, and use thereof
Assignee: Novartis Corp
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Filing: 1973-05-04
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Granted: 1975-10-21
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Expires: 1993-05-04
Abstract
Abstract Layer material and method for the rapid chromatographic identification of liquid substances, yielding reproducible and distinct ring chromatograms said layer containing A. at least two dyestuffs and B. a substrate layer suitable for carrying out chromatographic tests, and wherein A. THE DYESTUFFS ARE IN A FINE AND EVEN STATE OF DISTRIBUTION AND ARE IN CONTACT WITH THE SUBSTRATE LAYER, B. AT LEAST TWO DYESTUFFS YIELD COLOUR RINGS WHICH CAN BE SUFFICIENTLY DISTINGUISHED BY THE EYE, AND C. THE DYESTUFFS AND SUBSTRATE ARE SO ADJUSTED TO EACH OTHER THAT THE ENTIRE SYSTEM IS ABLE TO FORM A RING CHROMATOGRAM SPECIFIC TO A LIQUID SUBSTANCE WHICH IS TO BE IDENTIFIED, BY DEPOSITING A SMALL AMOUNT OF A LIQUID TO BE TESTED FOR ITS CONTENT OF THE LIQUID SUBSTANCE TO BE IDENTIFIED, ON A POINT ON THE SAID SUBSTRATE LAYER AND COMPARING THE RESULTING CHROMATOGRAM WITH ONE WHICH HAS BEEN OBTAINED IN SIMILAR MANNER WITH A TEST SAMPLE OF THE LIQUID SUBSTANCE TO BE IDENTIFIED.
Inventors
- 👤 Helmut Fuchs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:56
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/90; G01N30/95; B; B01; B01J; B01J20/00; B01J20/281; B01J20/286; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/321; B01J20/3212; B01J20/3214; B01J20/3223; B01J20/3231; B01J20/3234; B01J20/3236; B01J20/324; B01J20/3242; B01J20/3268; B01J20/3272; B01J2220/00; B01J2220/40; B01J2220/49; B01J2220/50; B01J2220/54
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
141 words
LAYER MATERIAL FOR THE RAPID CHROMATOGRAPHIC IDENTIFICATION OF A LIQUID COMPRISING: A. A SUBSTRATE-LAYER SUITABLE FOR CARRYING OUT CHROMATOGRAPHIC TESTS, AND B. A COMBINATION OF AT LEAST TWO ELUTABLE DYESTUFFS, I. SAID DYESTUFF COMBINATION BEING IN FINE AND EVEN DISTRIBUTION ON THE SURFACE OR IN THE INTERIOR OF SAID SUBSTRATE LAYER, II. AT LEAST TWO DYESTUFFS OF SAID COMBINATION HAVING DIFFERENT SOLUBILITIES IN SOLVENTS OF DIFFERENT POLARITIES, III. AT LEAST ONE DYESTUFF OF SAID COMBINATION BEING ELUTABLE THROUGH THE SUBSTRATE LAYER UPON CONTACT WITH THE LIQUID TO BE IDENTIFIED, AND IV. AT LEAST TWO OF SAID ELUTED DYESTUFFS HAVING COLOURS AFTER ELUTION, WHICH ARE SUFFICIENTLY DIFFERENT FROM ONE ANOTHER TO BE DISTINGUISHED BY THE EYE, THE SUBSTRATE LAYER AND THE DYESTUFFS BEING IN SUCH RELATIONSHIP TO ONE ANOTHER AS TO ENABLE THE FORMATION OF A RING CHROMATOGRAM CHARACTERISTIC FOR SAID LIQUID.
Claim 2
Dependent Claim
141 words
LAYER MATERIAL FOR THE RAPID CHROMATOGRAPHIC IDENTIFICATION OF A LIQUID COMPRISING: A. A SUBSTRATE-LAYER SUITABLE FOR CARRYING OUT CHROMATOGRAPHIC TESTS, AND B. A COMBINATION OF AT LEAST TWO ELUTABLE DYESTUFFS, I. SAID DYESTUFF COMBINATION BEING IN FINE AND EVEN DISTRIBUTION ON THE SURFACE OR IN THE INTERIOR OF SAID SUBSTRATE LAYER, II. AT LEAST TWO DYESTUFFS OF SAID COMBINATION HAVING DIFFERENT SOLUBILITIES IN SOLVENTS OF DIFFERENT POLARITIES, III. AT LEAST ONE DYESTUFF OF SAID COMBINATION BEING ELUTABLE THROUGH THE SUBSTRATE LAYER UPON CONTACT WITH THE LIQUID TO BE IDENTIFIED, AND IV. AT LEAST TWO OF SAID ELUTED DYESTUFFS HAVING COLOURS AFTER ELUTION, WHICH ARE SUFFICIENTLY DIFFERENT FROM ONE ANOTHER TO BE DISTINGUISHED BY THE EYE, THE SUBSTRATE LAYER AND THE DYESTUFFS BEING IN SUCH RELATIONSHIP TO ONE ANOTHER AS TO ENABLE THE FORMATION OF A RING CHROMATOGRAM CHARACTERISTIC FOR SAID LIQUID.
Claim 3
Dependent Claim
18 words
Layer material according to claim 1, wherein the dyestuffs (B) possess good stability on the absorbent substrate layer.
Claim 4
Dependent Claim
23 words
Layer material according to claim 1, wherein said substrate layer comprises at least one layer of a fine, evenly distributed organic absorbent substance.
Claim 5
Dependent Claim
83 words
Layer material according to claim 3, wherein said inorganic absorbent substance is selected from the group consisting of talcum, magnesium citrate, neutral sodium carbonate, potassium carbonate, calcium phosphate, calcium sulphate, magnesium carbonate, magnesium oxide, activated silica gel, diatomaceous earth, activated magnesium silicate, calcium silicate, activated aluminium oxide, activated magnesium oxide, calcium oxide, aluminium oxide, fuller''s earth, glass powder, salts of heteropolyacids, tungstic acid, molybdic acid, tetraboric acid, zinc carbonate, zinc ferrocyanide, and aluminium silicates, or combinations of two or more of these sorbents.
Claim 6
Dependent Claim
24 words
Layer material according to claim 4, which comprises a silica gel layer having a thickness of about 0.2 mm + or - 0.1 mm.
Claim 7
Dependent Claim
28 words
Layer material according to claim 1, wherein said organic absorbent substance is selected from the group consisting of cellulose, acetyl cellulose, polyamides, sucrose, dextrose, mannitol, charcoal, and starch.
Claim 8
Dependent Claim
67 words
Layer material according to claim 1, wherein the dyestuffs (B) are selected from the group consisting of fat-soluble dyes (Colour Index: Solvent Dyes), metal complex dyes which are soluble in organic solvents (CI: under Disperse Dyes), acid dyes (CI: Acid Dyes), water-soluble metal complex dyes (1:2 and 1:1 complexes), direct dyes (CI: Direct Dyes), and basic dyes, or compatible mixtures of at least two of said dyestuffs.
Claim 9
Dependent Claim
29 words
Layer material according to claim 7, wherein said dyestuffs (B) are at least one fat-soluble dye (Colour Index: Solvent Dyes) and at least one acid dye (CI: Acid Dyes).
Claim 10
Dependent Claim
44 words
Layer material according to claim 7, wherein the fat-soluble dyes are selected from the group consisting of dyes which are listed in the Colour Index as Solvent Blue 49, Solvent Yellow 16, Solvent Red 2, Solvent Yellow 14, CI 62545, and Solvent Red 98.
Claim 11
Dependent Claim
36 words
Layer material according to claim 7, wherein the acid dyes are selected from the group consisting of dyes which are listed in the Colour Index as Acid Blue 7, Acid Yellow 73, and Acid Orange 17.
Claim 12
Dependent Claim
12 words
Layer material according to claim 1, which alsO contains a binding agent.
Claim 13
Dependent Claim
16 words
Layer material according to claim 11, wherein the binding agent is starch, gypsum, or polyvinyl alcohol.
Claim 14
Dependent Claim
17 words
Layer material according to claim 1, wherein the chromatographic substrate layer (A) is supported on a carrier.
Claim 15
Dependent Claim
16 words
Layer material according to claim 13, wherein the carrier is a plate or a flexible foil.
Claim 16
Dependent Claim
31 words
Layer material according to claim 14, wherein the carrier is selected from the group consisting of stainless steel, aluminium, polymethylacrylate, polyvinyl chloride, polyethylene terephthalate, polyamide, polycarbonate, glass plate, and glass fabric.
Claim 17
Dependent Claim
23 words
Layer material according to claim 1, wherein said substrate layer comprises at least one layer of a fine, evenly distributed inorganic absorbent substance.
Claim 18
Independent Claim
189 words
A method for rapid identification of liquids which comprises depositing an amount of said liquid to a point of a layer material comprising A. a substrate-layer suitable for carrying out chromatographic tests, and B. a combination of at least two elutable dyestuffs, i. said dyestuff combination being in fine and even distribution on the surface or in the interior of said substrate layer, ii. at least two dyestuffs of said combination having different solubilities in solvents of different polarities, iii. at least one dyestuff of said combination being elutable through the substrate layer upon contact with the liquid to be identified, and iv. at least two of said eluted dyestuffs having colours, after elution, which are sufficiently different from one another to be distinguished by the eye, the substrate layer and the dyestuffs being in such relationship to one another as to enable the formation of a ring chromatogram characteristic for said liquid, and allowing radial diffusion from said point thereby forming concentric circular zones of different colours and different diameters through the varying migration of said dyestuffs, said concentric zones representing a ring chromatogram specific of said liquid.
Claim 19
Independent Claim
189 words
A method for rapid identification of liquids which comprises depositing an amount of said liquid to a point of a layer material comprising A. a substrate-layer suitable for carrying out chromatographic tests, and B. a combination of at least two elutable dyestuffs, i. said dyestuff combination being in fine and even distribution on the surface or in the interior of said substrate layer, ii. at least two dyestuffs of said combination having different solubilities in solvents of different polarities, iii. at least one dyestuff of said combination being elutable through the substrate layer upon contact with the liquid to be identified, and iv. at least two of said eluted dyestuffs having colours, after elution, which are sufficiently different from one another to be distinguished by the eye, the substrate layer and the dyestuffs being in such relationship to one another as to enable the formation of a ring chromatogram characteristic for said liquid, and allowing radial diffusion from said point thereby forming concentric circular zones of different colours and different diameters through the varying migration of said dyestuffs, said concentric zones representing a ring chromatogram specific of said liquid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-20 | 1979-04-21 | 1979-10-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-20 | 1983-04-21 | 1983-10-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-20 | 1987-04-21 | 1987-10-21 | $7700.00 | Window Closed / Lapsed |