US3887704A
Expired / Lapsed
US
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Aqueous zinc solutions for physiological use
Assignee: Individual
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Filing: 1974-03-12
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Granted: 1975-06-03
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Expires: 1994-03-12
Abstract
Abstract Aqueous zinc solutions for use in physiological administration containing a water-soluble zinc salt in a proportion sufficient to provide a physiologically active zinc ion concentration and at least one other physiologically active ingredient in a proportion normally tending to insolubilize the zinc ions. Insolubilization of the zinc is inhibited by incorporating in the solution a neutralized salt which is water-soluble at a pH within the range of from 5.0 to 8.5 and which has an acid moiety whose zinc salt is water-soluble at a pH in the range of from 5.0 to 8.5. The weight ratio of the neutralized salt to the zinc salt in the solution is within the range of from about 0.1 to about 40.
Inventors
- 👤 Joseph Lichtenstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:57
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/24; A61K33/30
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
170 words
A COMPOSITION FOR USE IN PHYSIOLOGICAL ADMINISTRATION COMPRISING AN AQUEOUS SOLUTION HAVING A PH WITHIN THE RANGE OF FROM 5.0 TO 8.5 OF A WATER-SOLUBLE ZINC SALT IN A PROPORTION SUFFICIENT TO PROVIDE A PHYSIOLOGICALLY ACTIVE ZINC ION CONCENTRATION, AT LEAST ONE OTHER PHYSIOLOGICALLY ACTIVE INGREDIENT SELECTED FROM THE GROUP CONSISTING OF WATER-SOLUVLE PHOSPHATES, SOAPS, FATTY ACIDS, PROTEINS AND PROTEIN HYDROLYSATES IN AND A NEUTRALIZED SALT WHICH IS WATER-SOLUBLE AT A PH WITHIN THE AND A NEUTRALIZED SALT WHICH IS WATER-SOLUBLE AT A PH WITHIN THE RANGE OF FROM 5.0 TO 8.5 SELECTED FROM THE GROUP CONSISTING OF WATER-SOLUBLE ALKALI METAL, ALKALINE EARTH METAL, ALKANOLAMINE, AMINE, AND QUATERNARY AMMONIUM SLATS OF AN ACID WHOSE ZINC SALT IS WATER-SOLUBLE AT A PH WITHIN THE RANGE OF FROM 5.0 TO 8.5, THE WEIGHT RATIO OF SAID NEUTRALIZED SALT TO SAID ZINC SALT BEING WITHIN THE RANGE OF FROM ABOUT 0.1 TO ABOUT 40, WHEREBY THE INSOLUBILIZATION OF SAID ZINC IONS BY SAID OTHER PHYSIOLOGICALLY ACTIVE INGREDIENT IS INHIBITED BY SAID NEUTRALIZED SALT.
Claim 2
Dependent Claim
170 words
A COMPOSITION FOR USE IN PHYSIOLOGICAL ADMINISTRATION COMPRISING AN AQUEOUS SOLUTION HAVING A PH WITHIN THE RANGE OF FROM 5.0 TO 8.5 OF A WATER-SOLUBLE ZINC SALT IN A PROPORTION SUFFICIENT TO PROVIDE A PHYSIOLOGICALLY ACTIVE ZINC ION CONCENTRATION, AT LEAST ONE OTHER PHYSIOLOGICALLY ACTIVE INGREDIENT SELECTED FROM THE GROUP CONSISTING OF WATER-SOLUVLE PHOSPHATES, SOAPS, FATTY ACIDS, PROTEINS AND PROTEIN HYDROLYSATES IN AND A NEUTRALIZED SALT WHICH IS WATER-SOLUBLE AT A PH WITHIN THE AND A NEUTRALIZED SALT WHICH IS WATER-SOLUBLE AT A PH WITHIN THE RANGE OF FROM 5.0 TO 8.5 SELECTED FROM THE GROUP CONSISTING OF WATER-SOLUBLE ALKALI METAL, ALKALINE EARTH METAL, ALKANOLAMINE, AMINE, AND QUATERNARY AMMONIUM SLATS OF AN ACID WHOSE ZINC SALT IS WATER-SOLUBLE AT A PH WITHIN THE RANGE OF FROM 5.0 TO 8.5, THE WEIGHT RATIO OF SAID NEUTRALIZED SALT TO SAID ZINC SALT BEING WITHIN THE RANGE OF FROM ABOUT 0.1 TO ABOUT 40, WHEREBY THE INSOLUBILIZATION OF SAID ZINC IONS BY SAID OTHER PHYSIOLOGICALLY ACTIVE INGREDIENT IS INHIBITED BY SAID NEUTRALIZED SALT.
Claim 3
Dependent Claim
167 words
A composition for use in physiological administration comprising an aqueous solution having a pH within the range of from 5.0 to 8.5 of a water-soluble zinc salt in a proportion sufficient to provide a physiologically active zinc ion concentration, at least one other physiologically active ingredient selected from the group consisting of water-soluble phosphates, soaps, fatty acids, proteins and protein hydrolysates in a proportion normally tending to insolubilize said zinc ions, and a neutralized salt which is water-soluble at a pH within the range of from 5.0 to 8.5 selected from the group consisting of water-soluble alkali metal, alkaline earth metal, alkanolamine, amine, and quaternary ammonium salts of an acid whose zinc salt is water-soluble at a pH within the range of from 5.0 to 8.5, the weight ratio of said neutralized salt to said zinc salt being within the range of from about 0.1 to about 40, whereby the insolubilization of said zinc ions by said other physiologically active ingredient is inhibited by said neutralized salt.
Claim 4
Dependent Claim
167 words
A composition for use in physiological administration comprising an aqueous solution having a pH within the range of from 5.0 to 8.5 of a water-soluble zinc salt in a proportion sufficient to provide a physiologically active zinc ion concentration, at least one other physiologically active ingredient selected from the group consisting of water-soluble phosphates, soaps, fatty acids, proteins and protein hydrolysates in a proportion normally tending to insolubilize said zinc ions, and a neutralized salt which is water-soluble at a pH within the range of from 5.0 to 8.5 selected from the group consisting of water-soluble alkali metal, alkaline earth metal, alkanolamine, amine, and quaternary ammonium salts of an acid whose zinc salt is water-soluble at a pH within the range of from 5.0 to 8.5, the weight ratio of said neutralized salt to said zinc salt being within the range of from about 0.1 to about 40, whereby the insolubilization of said zinc ions by said other physiologically active ingredient is inhibited by said neutralized salt.
Claim 5
Dependent Claim
28 words
The composition of claim 1 wherein the weight ratio of said neutralized salt to said zinc salt is within the range of from about 1 to about 10.
Claim 6
Dependent Claim
21 words
The composition of claim 1 wherein the pH of said aqueous solution is within the range of from 6.0 to 7.5.
Claim 7
Dependent Claim
29 words
The composition of claim 1 wherein said water-soluble zinc salt is present in a proportion sufficient to provide an active zinc ion concentration on the order of about 0.1%.
Claim 8
Dependent Claim
26 words
The composition of claim 1 wherein said water-soluble zinc salt is selected from the group consisting of zinc chloride, zinc nitrate, zinc sulfate and zinc acetate.
Claim 9
Dependent Claim
45 words
The composition of claim 1 wherein the acid moiety of said neutralized salt is selected from the group consisting of chloride, iodide, bromide, acetate, lactate, benzoate, citrate, butyrate, glycerophosphate, nitrate, salicylate, tartrate, valerate, propionate, phenolsulfonate, toluenesulfonate, formaldehydesulfoxalate, ethylenediaminetetraacetate, sulfate, bisulfate, chlorate, perchlorate, hypophosphate and glycholate.
Claim 10
Dependent Claim
23 words
The composition of claim 1 additionally containing ethylenediaminetetracetic acid in a weight ratio to zinc of no greater than about 6 to 1.
Claim 11
Dependent Claim
140 words
In a method for the physiological administration of an aqueous solution containing a water-soluble zinc salt in a proportion sufficient to provide a physiologically active zinc ion concentration and at least one other physiologically active ingredient in a proportion normally tending to insolubilize said zinc ions, the improvement comprising inhibiting the insolubilization of said zinc ions in said solution by incorporating in said solution a neutralized salt which is water-soluble at a pH within the range of from 5.0 to 8.5 selected from the group consisting of water-soluble alkaline earth metal, alkali metal, alkanolamine, amine, and quaternary ammonium salts of an acid whose zinc salt is water-soluble at a pH within the range of from 5.0 to 8.5, the weight ratio of said neutralized salt to said zinc salt being within the range of from about 0.1 to about 40.
Claim 12
Dependent Claim
140 words
In a method for the physiological administration of an aqueous solution containing a water-soluble zinc salt in a proportion sufficient to provide a physiologically active zinc ion concentration and at least one other physiologically active ingredient in a proportion normally tending to insolubilize said zinc ions, the improvement comprising inhibiting the insolubilization of said zinc ions in said solution by incorporating in said solution a neutralized salt which is water-soluble at a pH within the range of from 5.0 to 8.5 selected from the group consisting of water-soluble alkaline earth metal, alkali metal, alkanolamine, amine, and quaternary ammonium salts of an acid whose zinc salt is water-soluble at a pH within the range of from 5.0 to 8.5, the weight ratio of said neutralized salt to said zinc salt being within the range of from about 0.1 to about 40.
Claim 13
Dependent Claim
28 words
The method of claim 8 wherein the weight ratio of said neutralized salt to said zinc salt is within the range of from about 1 to about 10.
Claim 14
Dependent Claim
45 words
The method of claim 8 wherein the acid moiety of said neutralized salt is selected from the group consisting of chloride, iodide, bromide, acetate, lactate, benzoate, citrate, butyrate, glycerophosphate, nitrate, salicylate, tartrate, valerate, propionate, phenolsulfonate, toluenesulfonate, formaldehydesulfoxalate, ethylenediaminetetraacetate, sulfate, bisulfate, chlorate, perchlorate, hypophosphate and glycholate.
References Cited (Backward Citations)
US3087861A
Cited
US3509254A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-02 | 1978-12-02 | 1979-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-02 | 1982-12-02 | 1983-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-02 | 1986-12-02 | 1987-06-03 | $7700.00 | Window Closed / Lapsed |