US3884802A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Liquid chromatography injection system
Assignee: Packard Becker BV
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Filing: 1973-10-05
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Granted: 1975-05-20
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Expires: 1993-10-05
Abstract
Abstract A method and apparatus for quickly and efficiently injecting variable size fluid samples into the solvent flow stream of a high pressure liquid chromatography system. The injection apparatus includes a laterally moveable valve member that is formed with a pair of parallel transverse passages and is initially positioned such that one of the passages is aligned with the solvent flow stream. The apparatus further includes means for receiving and supporting a syringe so that the end of the needle is disposed within the valve at the other transverse valve passage, a selectively engageable sealing member for sealing the syringe needle and valve once the syringe is in position, and means for simultaneously moving the syringe, sealing member, and valve to a position such that said other transverse valve passage is in said flow stream enabling a sample within the syringe to be injected into the flow stream without depressurization of the system or substantial interruption of the flow stream.
Inventors
- 👤 Johannes Spaans
- 👤 Adrianus Onderwater
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:36
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/04; G01N30/16; G01N30/18; G01N30/20; G01N2030/204; G01N30/22
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
186 words
A SAMPLE INJECTION APPARATUS FOR USE IN A LIQUID CHROMATOGRAPHY SYSTEM IN WHICH A CONTINUOUS HIGH PRESSURE, HIGH VELOCITY SOLVENT STREAM IS DIRECTED THROUGH A COLUMN COMPRISING, IN COMBINATION, A VALVE HOUSING, A VALVE MEMBER MOUNTED FOR RELATIVE LATERAL SLIDING MOVEMENT WITHIN SAID HOUSING, SAID VALVE MEMBER BEING FORMED WITH A PAIR OF PASSAGES EXTENDING TRANSVERSELY THROUGH SAID MEMBER, SAID VALVE MEMBER BEING POSITIONABLE SUCH THAT ONE OF SAID TRANSVERSE PASSAGES IS IN ALIGNMENT WITH SAID SOLVENT STREAM SO THAT SAID STREAM FLOWS THROUGH SAID ONE PASSAGE, A SIMPLE HOLDING MEANS FOR SELECTIVELY DRAWING IN AND EJECTING VARIABLE QUANTITIES OF A SAMPLE, SAID SAMPLE HOLDING MEANS HAVING AN OUTLET AT ONE END THEREOF AND BEING REMOVABLY POSITIONABLE WITHIN SAID VALVE MEMBER SUCH THAT SAID OUTLET IS DISPOSED AT THE OTHER OF SAID TRANSVERSE VALVE PASSAGES, AND MEANS FOR LATERALLY MOVING SAID VALVE MEMBER WITH SAID SAMPLE HOLDING MEANS POSITIONED THEREIN FROM A POSITION WHERE SAID ONE VALVE PASSAGE IS ALIGNED WITH SAID SOLVENT STREAM TO A POSITION WHERE SAID OTHER VALVE PASSAGE IS ALIGNED WITH SAID SOLVENT STREAM AND SAID SOLVENT FLOWS THROUGH SAID OTHER PASSAGE.
Claim 2
Dependent Claim
186 words
A SAMPLE INJECTION APPARATUS FOR USE IN A LIQUID CHROMATOGRAPHY SYSTEM IN WHICH A CONTINUOUS HIGH PRESSURE, HIGH VELOCITY SOLVENT STREAM IS DIRECTED THROUGH A COLUMN COMPRISING, IN COMBINATION, A VALVE HOUSING, A VALVE MEMBER MOUNTED FOR RELATIVE LATERAL SLIDING MOVEMENT WITHIN SAID HOUSING, SAID VALVE MEMBER BEING FORMED WITH A PAIR OF PASSAGES EXTENDING TRANSVERSELY THROUGH SAID MEMBER, SAID VALVE MEMBER BEING POSITIONABLE SUCH THAT ONE OF SAID TRANSVERSE PASSAGES IS IN ALIGNMENT WITH SAID SOLVENT STREAM SO THAT SAID STREAM FLOWS THROUGH SAID ONE PASSAGE, A SIMPLE HOLDING MEANS FOR SELECTIVELY DRAWING IN AND EJECTING VARIABLE QUANTITIES OF A SAMPLE, SAID SAMPLE HOLDING MEANS HAVING AN OUTLET AT ONE END THEREOF AND BEING REMOVABLY POSITIONABLE WITHIN SAID VALVE MEMBER SUCH THAT SAID OUTLET IS DISPOSED AT THE OTHER OF SAID TRANSVERSE VALVE PASSAGES, AND MEANS FOR LATERALLY MOVING SAID VALVE MEMBER WITH SAID SAMPLE HOLDING MEANS POSITIONED THEREIN FROM A POSITION WHERE SAID ONE VALVE PASSAGE IS ALIGNED WITH SAID SOLVENT STREAM TO A POSITION WHERE SAID OTHER VALVE PASSAGE IS ALIGNED WITH SAID SOLVENT STREAM AND SAID SOLVENT FLOWS THROUGH SAID OTHER PASSAGE.
Claim 3
Dependent Claim
25 words
The injection apparatus of claim 1 including selectively engageable and releasable sealing means for sealing said sample holding means with respect to said valve member.
Claim 4
Dependent Claim
60 words
The injection apparatus of claim 2 wherein said sample holding means is a syringe having a needle, a sample containing portion, and means for drawing in and ejecting a sample from said containing portion, said valve sealing means being engageable with said needle, and said moving means simultaneously moves said valve member, syringe, and sealing means without relative movement therebetween.
Claim 5
Dependent Claim
44 words
The injection apparatus of claim 1 in which said valve housing is formed with ports to permit passage of said solvent stream, and said moving means moves said valve member between positions wherein said valve transverse passages are alternately aligned with said housing ports.
Claim 6
Dependent Claim
58 words
The injection apparatus of claim 1 in which said valve member includes a coaxially disposed transfer sleeve having a threaded portion, a rotatably mounted handle means having a threaded portion in operative engagement with said threaded transfer sleeve whereby rotation of said handle means causes lateral movement of said transfer sleeve and valve member relative to said housing.
Claim 7
Dependent Claim
147 words
The sample injection apparatus of claim 3 including a guide member mounted concentrically within said transfer sleeve for relative lateral movement, said guide member having an end portion received within the end of said valve member, a sealing member disposed within said valve member in surrounding relation to said guide member end portion, said guide member having a central bore for receiving the sample containing portion of said syringe, said guide member, sealing member, and valve member each being formed with concentric axial ports which communicate from said guide member central bore to said other transverse valve passage for receiving the needle of a syringe positioned within said guide member, and means for moving said guide member relative to said transfer sleeve and valve member to cause said guide member to tightly compress said sealing member about the needle of a syringe positioned within said guid member.
Claim 8
Dependent Claim
49 words
The apparatus of claim 6 in which said guide member moving means includes an externally threaded shoulder on said guide member that is in threaded engagement with an internally threaded portion of said transfer sleeve whereby rotation of said guide member moves said guide member relative to said sleeve.
Claim 9
Dependent Claim
54 words
The apparatus of claim 7 in which said valve is formed with a conical shaped bore for receiving said sealing member, and said sealing member has a complementary shaped conical end that is engageable with said valve bore upon lateral advancing movement of said guide member relative to said transfer sleeve and valve member.
Claim 10
Dependent Claim
29 words
The injection apparatus of claim 8 in which said guide member has a handle portion at its outermost end for rotating said guide member relative to said transfer sleeve.
Claim 11
Independent Claim
131 words
A method of introducing a liquid sample into a fluid flow stream of a high pressure liquid chromatography system of a type which has a syringe receiving valve with a pair of transverse passages comprising the steps of drawing into a syringe a desired volume of the liquid sample, positioning said valve so that one of said transverse passages is in the fluid flow stream and fluid flows through said passage, inserting the syringe into the valve member with the outlet end of said syringe disposed at the other of said transverse passages, and moving said valve and syringe to a position whereby said other passage is in the fluid flow stream so that solvent passEs through said other passage, and ejecting the sample from the syringe into the flow stream.
Claim 12
Independent Claim
131 words
A method of introducing a liquid sample into a fluid flow stream of a high pressure liquid chromatography system of a type which has a syringe receiving valve with a pair of transverse passages comprising the steps of drawing into a syringe a desired volume of the liquid sample, positioning said valve so that one of said transverse passages is in the fluid flow stream and fluid flows through said passage, inserting the syringe into the valve member with the outlet end of said syringe disposed at the other of said transverse passages, and moving said valve and syringe to a position whereby said other passage is in the fluid flow stream so that solvent passEs through said other passage, and ejecting the sample from the syringe into the flow stream.
Claim 13
Dependent Claim
35 words
The method of claim 10 including forming a seal between said syringe and valve prior to moving said valve, and after said seal is formed moving said syringe, valve, and seal without relative movement therebetween.
Claim 14
Dependent Claim
68 words
The method of claim 11 including drawing into said syringe a quantity of fluid from said flow stream after said sample has been injected, moving said valve, seal and syringe to a position whereby said other valve passage is removed from said flow stream and said one valve passage is located in said flow stream, releasing the seal about said syringe, and removing said syringe from said valve.
References Cited (Backward Citations)
US3150517A
Cited
US3540852A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-19 | 1978-11-18 | 1979-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-19 | 1982-11-18 | 1983-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-19 | 1986-11-18 | 1987-05-20 | $7700.00 | Window Closed / Lapsed |